<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09267

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASIAFRIYESSTDQSHSFQSSALEIQSTLRDQGKLVSYDADRGAIWIFQITNKDGANKAVSFGSGVSLEACGYTLGMVEEGTLEPAALQKNRIPGNTTQNAATSTAATTSPAEPYQRNPLISPTQIAGIQAEGGVQPPAQPVDTKTTQPVPKVIYEQFIIAVISAITFAFCSQSTAVPLNYRTILIPPLQADRNEHEKDSLQADPLIGTFKTYLTTTGSLVVSLYFSYCQNLATVEDVLSGDSPSLSGSILAAPYGVFAAKSGFSSGDADRSLAQTPNTQALSVRSFPEAHDSLWKHSCLRALEYCGLNPSNFKAGPWVNLLITKPTSQDIDGEQKRLRATVPWPGALCFRKKSLEVSTTHRVGDTILSGHEECHDPLGDARGWFASTSEREERVSRRKSDRAYAAAKEVNGANLQAQSLNGQSPLSVRRPSTATAGVMYPTPPDGIQQHLGVTPSIDGATSSPNNHPPTLAVVDADATMPTVTPMADADHDTWDGGHEQKRERSDSNLLGDTDDIMNGMGGDVFGDHDVTEDDFNFFDGPDGNDMDIDMSDLHPISHPPPPQAIPHQTTPPQAIPPQAILPQTIFTQVMPPPMITQPQLQKVIEPQPQPKIRSKPKTHEPVFAKPELKHARSSLNDEINHKVKTERSNSNKRGSSPFDPDTVFKRVKASLTSPTQENFTFQAPLRRKSSIFEKVEFDPKIPLINKKYEHGGAFDFSKDQSSVELKRDSEGLSTDEYLERQGKIKPDSKTLSGVSLIRSLTGVDGSANHSNAQKSNGNASFSEDSDADSEADDLSSISGGPMSPIKSSVKRTVVDDDALSQATTSREADLIDDATEEQFAIELPKLSKTESPEMPLHRFFSDPEPLNAEVGLSNLEFVEVAQIITEQAATGRLDIGIDHKKESSIALATMKGHELNVARSSLQLLQNIIPSNLGSATAVRLKGLLEILDLPLVGRPNRLQPRPIPGRDTNVEQLRPNNLYQIPVPHLEVRRSETKLSVLPSSISFWEGLGLSPSWGAKDVTALCIFPGWKGMSDHVGSFLDRSKSVYESLKLGTFNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSSLVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSELLAARRESPQNELVLQLVSSNLISSTTSLVVPTPAEMIKLCVETYDRCTLFLAPEHGGPTPAPAVMLEQPPPRMIDFKLTISPSQSLMHENSCIHVGYAESLDGRWITAAWTDNRGQRQATASYSITRSRTPDRSASQNKAAIITEIWATTLSMISIWKVHWRVIITRAGPMDQKEVEWWQAASTLDDKYSFTMILMSVDTSPSLQLVPPVVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRETSTLAATPGAESVTEPDADSFLIDATDQTWGAIAAHRFGNSTTLLEVRPALASGYLIKRTGIKIEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVTDRETDVRPWHIAVAEKGVRALHLLL
Length1541
PositionKinase
OrganismFusarium poae
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.376
Instability index48.98
Isoelectric point5.27
Molecular weight168141.83
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09267
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.86|      17|      21|    1062|    1078|       1
---------------------------------------------------------------------------
 1062- 1078 (29.03/19.94)	V..YESLKLGTFNNLPLSG
 1084- 1102 (23.82/14.78)	VlpYEVDRISTSPDATVTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.68|      17|      17|     598|     614|       2
---------------------------------------------------------------------------
  578-  593 (31.33/16.60)	PQAIPHQTTPPQAI.PP
  598-  614 (34.70/19.28)	PQTIFTQVMPPPMITQP
  632-  642 (19.65/ 7.30)	PKT......HEPVFAKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.77|      37|     190|    1154|    1192|       3
---------------------------------------------------------------------------
 1154- 1192 (56.32/43.71)	DEYS..ELLAARRESPQNELVLQLVssNLISSTTSLVVPTP
 1346- 1384 (61.45/41.32)	DKYSftMILMSVDTSPSLQLVPPVV..KIPHAATSAFYSTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.44|      18|     190|     478|     498|       4
---------------------------------------------------------------------------
  440-  458 (28.97/ 7.36)	SPlSVRRPSTAT..AGVMYPT
  479-  498 (29.48/19.25)	SP.NNHPPTLAVvdADATMPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.92|      15|      16|     543|     557|       5
---------------------------------------------------------------------------
  506-  539 (16.22/ 6.69)	DHDTwdggheqkrersdsnllgdTDDIMNGMGGD
  543-  557 (29.35/18.95)	DHDV...................TEDDFNFFDGP
  561-  575 (26.35/16.15)	DMDI...................DMSDLHPISHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     250.68|      83|     491|     204|     308|       6
---------------------------------------------------------------------------
  204-  308 (118.58/127.66)	PLQADRNEHEKdsLQADPLIGTFKTYLTTTGSlvvslyFSYCQNLATVEdvLSGDSPSLSG....................SILAAPYGVfaaksgfsSGDADRSLAQTPNTQAlsvrSFPEAHD
  700-  802 (132.10/88.05)	PLRRKSSIFEK..VEFDPKIPLINKKYEHGGA......FDFSKDQSSVE..LKRDSEGLSTdeylerqgkikpdsktlsgvSLIRSLTGV........DGSANHSNAQKSNGNA....SFSEDSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.29|      11|      17|     971|     981|      10
---------------------------------------------------------------------------
  971-  981 (23.36/13.98)	RPNRLQPRPIP
  991- 1001 (22.93/13.57)	RPNNLYQIPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.40|      63|     876|     359|     424|      13
---------------------------------------------------------------------------
  359-  424 (107.49/72.85)	PWPGALCFRkksLEVSTTHRV...GDTILSGHEECHDPLGDARGWFASTSEREE....RVSR.RKSDRAYAAAK
 1228- 1298 (97.91/59.42)	PPPRMIDFK...LTISPSQSLmheNSCIHVGYAESLDGRWITAAWTDNRGQRQAtasySITRsRTPDRSASQNK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09267 with Med13 domain of Kingdom Fungi
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