Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDGRFERLEKALANLIDSVTKFHPSIQQGDELDAADKELTKGLEEVQTHQNNYLRIQQLRESSAALDTQIRETLSNLATTRKDIVTTHTTTFPAGPSYAIAYEELLNYARRISKTTMPPAGTIKAAPATAAPPTPDGQTPGVQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSAMSANTSLPNEWTQFLNPLTDQIFVPWPNDLQLGAGALAAHQVLLEQGINPKGYDPAEEEERKRREEEERKKKEEEDRIAQEEREKKLREERERQRIERERQREKDQEAWRRASLVGGPTAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 343 |
Position | Middle |
Organism | Fusarium poae |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.015 |
Instability index | 55.76 |
Isoelectric point | 4.81 |
Molecular weight | 38288.63 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP09263 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.12| 12| 15| 255| 269| 1 --------------------------------------------------------------------------- 255- 266 (21.40/14.44) REEEERKKKEEE 279- 290 (21.72/ 6.75) REERERQRIERE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 122.26| 28| 28| 119| 146| 2 --------------------------------------------------------------------------- 93- 118 (26.04/ 9.10) TTTFPAG.....PsyAIAYEELLNyARRISK 119- 146 (50.49/23.37) TTMPPAGTIKAAP..ATAAPPTPD.GQTPGV 147- 174 (45.73/20.59) QTPGPDSQTASVM..TPSAPPSSQ.VQSPAV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 83.66| 27| 30| 30| 56| 3 --------------------------------------------------------------------------- 30- 56 (45.03/30.07) IQQGDELDAA.DKELTKGLEEVQTHQNN 60- 87 (38.64/24.80) IQQLRESSAAlDTQIRETLSNLATTRKD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EAWRRASLVGGPT 2) PPQQKAQFQFTNLDDLDDD | 298 321 | 310 339 |
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