<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09255

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPMIMEDSIDVDDLFGDPTSLELGLEGAAPTLKGLPQRLDELRLSGCSQKVGWSKLGAIAYVSLDGQKVLLRYLHCRPEDGKWTLSEESPINQVADVHGGHTIIHLLWNESGSELAIVDSGGRISIVTILTTLNTINVARQASIDPDDDCAQPVGLMWLNVNRPLFGFHQATRTNDRWSYPAYRRRPLGPLHPVNKPGLVLVTKSGHIKLIYQNPDARWAEISTELKTVGYLDGLLTHAAMAPAEGSGISIATHSACGKICFYRVQVKWEPPEWDQTAKAGGGANNAFPTPGFQVLHTKTEVLSTVFHPPAHDVENITGFSPANGAIYNLTHLEIITAPQVLPGTHTASGPCILAVASMPAHNQVGPPPPPGPSSVLIRWQLDTLVQALHPSFDDVVSKKTASNPKSKIVFRRLDDICFDRFVISVEYTEAGSVLAITFDDSSISYFEARSMRPINENEDVSIVTSMPNAGFTFPIDASGSLHIAFSPSGCLAVVLDGDWQLHLRYMEHSFGMEDDMYDNGKFSCAIAALALGYVRACGSDASADDILTVIVRQLNPDAQRSFVTEVYSILFMSIDFTEQDKLVNNQSIQKGLSMQAVLGFKSRFQPRAPSSAVPWIILNIRQIMMLVLTFSHYLKSGRDATPYEPEVLRMVLGNVKWILDLAKYLVDSLLEIADTLPADRSSFSLSNKTYESPALTLVLSSVPRSFLRHIFRYLSRFPVTFRAANNLSGESYQLFASINNTIEQSSLKADVCEKMLAHIDSLVTRSYEAAGFGNGERNAPEREMLITCSIPPVLQPAVMSILTETMPQIVRPEVDRMALALYDYSWLGVGDDKRTEHFKRTHDVDILKRNVGKLLDRTVAKRRCVRCCEISADVSLPKSVSMYRWIGKIGVLRTCVCGGSFAMENVEGLNRAPFSVFR
Length919
PositionTail
OrganismEmmonsia sp. CAC-2015a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia> unclassified Emmonsia.
Aromaticity0.08
Grand average of hydropathy-0.054
Instability index47.33
Isoelectric point6.02
Molecular weight101343.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09255
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.85|      36|     156|     479|     524|       1
---------------------------------------------------------------------------
   89-  125 (59.95/40.13)	SPINQVADVHGGHTIIHLLWNES..GSELAIVDSgGRIS
  487-  524 (64.90/52.89)	SPSGCLAVVLDGDWQLHLRYMEHsfGMEDDMYDN.GKFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.69|      14|     163|     646|     659|       3
---------------------------------------------------------------------------
  646-  659 (26.98/20.38)	PEVLRMVLG..NVKWI
  813-  828 (22.71/15.84)	PEVDRMALAlyDYSWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.90|      75|     134|       8|      88|       5
---------------------------------------------------------------------------
    8-   88 (112.34/83.54)	SIDVDDLFGDPTSLeLGLEGAAPtLKGLPQ..RLDElRLSGCSQKvgWSKLGAIAYVSLDGQKVLLRYLHCR.....PeDGKWT.LSEE
  143-  225 (128.56/73.31)	SIDPDDDCAQPVGL.MWLNVNRP.LFGFHQatRTND.RWSYPAYR..RRPLGPLHPVNKPGLVLVTKSGHIKliyqnP.DARWAeISTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.95|      26|      46|     703|     731|       6
---------------------------------------------------------------------------
  703-  731 (40.88/38.70)	VPRSFLRHIFRYLSRfpvTFRAANNLSGE
  752-  777 (46.06/32.94)	VCEKMLAHIDSLVTR...SYEAAGFGNGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.14|      65|      80|     289|     356|       7
---------------------------------------------------------------------------
  289-  356 (104.94/76.25)	PTPGFQVLHTKTEVLSTVFHPPAHD.VENITGFSPANGAIYNltHLEIITAPQ.VLPGTHTASGpCILAV
  371-  437 (101.20/63.17)	PGPSSVLIRWQLDTLVQALHPSFDDvVSKKTASNPKSKIVFR..RLDDICFDRfVISVEYTEAG.SVLAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09255 with Med16 domain of Kingdom Fungi
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