<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09250

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDAHQSSSSHTGPPPSPSSPAVDTAKSHQLHQQNRSKDQTPHTPTSPPLMSVSAQNYASSFSTTRTSPVQTLRPASLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSVGGHFANNHTMDEVEGAPKNVTADTLKSEESSMGKESGLDFMDIDTSEYRRTDHDRQKKGPDSNLDENTMDLDYRAVSSSQEEEISLAALQQDIGTAFHLCKSSYTTSGPNPSLDLVSLYGLGLVAASVARTDPVTGEKINRLRKSYEGKIKGLGLAGRNKPVKAEPGATGGLRYLTLWPEEEWKNQKVYGKDIKVAEPDSSFFRQQLKAMKMEPGTLPNHEFWEDALGHEKPPKVIAAADVSMAKTTTGTVPGSIHHSIHTNGAPPSISTSSAENTRPKRTGKKRSYNDSSFAGYGEGFPDDEADLESGLYSNSEEGGRGPGKKKRKKVPALPFLAISCDPDIPLL
Length456
PositionHead
OrganismEmmonsia sp. CAC-2015a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia> unclassified Emmonsia.
Aromaticity0.05
Grand average of hydropathy-0.752
Instability index50.11
Isoelectric point6.29
Molecular weight48954.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09250
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.45|      30|      31|      47|      77|       1
---------------------------------------------------------------------------
   20-   44 (39.32/17.06)	SP......AVDTAKSHQLHQQNRSKDQTPHT
   47-   77 (47.26/25.49)	SPPlMSVSAQNYASSFSTTRTSPVQTLRPAS
   80-  107 (42.87/19.22)	SPP.SSVAMSTQVSQ.QPTVTSTTSFPTPA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.10|      14|      31|     230|     259|       2
---------------------------------------------------------------------------
  230-  247 (20.31/38.93)	GLGLVAasvaRTDPVTGE
  262-  275 (25.79/ 7.46)	GLGLAG....RNKPVKAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.95|      29|      31|     321|     350|       3
---------------------------------------------------------------------------
  291-  309 (24.90/11.73)	.............EEWKNQKVYGKDIKV.AEPD
  321-  350 (50.35/35.40)	KMEPGTLP...NHEFWEDALGHEKPPKViAAAD
  355-  378 (26.71/12.79)	KTTTGTVPgsiHHSIHTNG....APPSI.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.81|      12|      25|     143|     159|       4
---------------------------------------------------------------------------
  143-  154 (22.62/ 6.64)	GKESGLD..FMDID
  169-  182 (17.20/ 9.14)	GPDSNLDenTMDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.39|      13|     202|       5|      17|       5
---------------------------------------------------------------------------
    5-   17 (27.94/12.25)	HQSSSSHT..GPPPS
  208-  222 (23.45/ 9.25)	HLCKSSYTtsGPNPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09250 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KTTTGTVPGSIHHSIHTNGAPPSISTSSAENTRPKRTGKKRSYNDSSFAGYGEGF
2) MSDAHQSSSSHTGPPPSPSSPAVDTAKSHQLHQQNRSKDQTPHTPTSPPLMSVSAQNYASSFSTTRTSPVQTLRPASLSSPPSSVAMSTQVSQQPTVTSTTSFPTPASSVGGHFANNHTMDEVEGAPKNVTADTLKSEESSMGKESGLDFMDIDTSEYRRTDHDRQKKGPDSNLDENTMDLDYRAVS
355
1
409
187










Molecular Recognition Features






MoRF SequenceStartStop




1) ADLESGLYS
2) RGPGKKKRKKVPAL
414
429
422
442