<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09249

Description Uncharacterized protein
SequenceMIPHPSSHRPPSRPAPPSSGPSAPSVHHATPDVPQRVDCSSQQNVVIDLTEPEFSDTADIGRPAKRLRLDTGNEPPSASLDYHQQQHQQQQQQLQLQEQQQQQQYQNQSNPEHQWPSTAGEAPEISMNPLDLMNASSTEQTARPPWSFGTVIPRPGAEGQPELSQWPQPASLPPLPLRPWKYGPQERYLASTPKPKDGMEGGEVQTTPYHIDIPSVAPRFADNKPADFAPWTGSQPEDVLSEQTAKQGFYDRVQVSSNESASARATLYTHFKHRSGLKILSSVFAAALEKRQAQCTITTASTFRPPPRVTLTDIKREAWLRDLANPSVPLRRLSRTIPHGIRGKVLLDQCLGKSIPICRAIWLAKCVGANELRAFKRKGTSAGVASGLESKWVRDWTIGVQQFIEGVIASVGDANWKLRISYSIRLSSRLFLEHLVEQDHFLDWFLTSLDNASFESLPVWLLMIGVYWQNILRYRKRGRRLVECILEKLRLATETDQNGSLNPLIRRLSRLIKSFSHNHPSSFILPRSWAKYDRVLLSCLDMNVPDDRAVFEKLKARNTRVCRLKNDRGKSTRSPHQRLIQLLDSSNDVHTICTECLNISRDYSILVSKIIEWASTTFRYGLARKYTAVRIFRRWKKAGIDIDFHLLSFLMQNHQKSGVQLLDVFHVICELVRSQSFSVAKYLQWLMARGVVSNISEFPQKNVSGDIGLLGHLPACRLPNHIWSLRNTLLSRTGFSVTIEDDTIQRIKASVRRRLPNMFPQLSPNWDAEMTDDVDLASLSWTVKSEIGNWIRDQVASHVKQSLKYVFKSGLICANPTRTTTASCQQRLVGSSSRAVKRKVTA
Length842
PositionKinase
OrganismEmmonsia sp. CAC-2015a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia> unclassified Emmonsia.
Aromaticity0.08
Grand average of hydropathy-0.463
Instability index53.45
Isoelectric point9.66
Molecular weight95192.37
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09249
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     197.20|      46|      48|      71|     116|       1
---------------------------------------------------------------------------
   16-   68 (46.85/21.92)	....PPSsgpsapsvhhAT...PDVPQRVDCSSQQNvvIDLTEPEFSDT.ADIGRPA.KRLR
   71-  116 (83.70/44.96)	TGNEPPS..........AS...LDYHQQQHQQQQQQ..LQLQEQQQQQQYQNQSNPE.HQWP
  118-  167 (66.66/34.31)	TAGEAPE..........ISmnpLDLMNASSTEQTAR..PPWSFGTVIPRPGAEGQPElSQWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     549.92|     179|     188|     416|     602|       2
---------------------------------------------------------------------------
  325-  463 (155.22/117.49)	..........................................NPSVplRRLSRTiphgIRGkvlLDQ.....................CLGKSI..PICRAIWlaKCVGANELRAFKRKGTSAGVASGLESKWVR..DWTIGVQQFIEGVIASVGDanWKLRISYSIRLSSRLFLEHLVEQDH....FLDWFLTSLDnASFESLPvwLLM
  464-  651 (285.68/221.55)	IGVYWQNILRY...RKRGRRL.VECILEKLrLATETDQNGSLNPLI..RRLSRL....IKS...FSHnHPSSFILPRSWAkYDRVLLSCLDMNV..PDDRAVF..EKLKARNTRVCRLKNDRGKSTRSPHQRLIQllDSSNDVHTICTECLNISRD..YSILVSKIIEWASTTFRYGLARKYTavriFRRWKKAGID.IDFHLLS..FLM
  657-  757 (109.01/70.06)	SGVQLLDVFHViceLVRSQSFsVAKYLQWL.MARGVVSNISEFPQ...KNVSGD....IGL...LGH.LPACRLPNHIWS.LRNTLLSRTGFSVtiEDD..TI..QRIKASVRR..RLPN..........................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.29|      34|      49|     170|     205|       3
---------------------------------------------------------------------------
  170-  205 (55.37/40.02)	ASLP..........PLPLRPWKyGPQERYLASTPKPKDGMEgGEVQ
  211-  254 (54.92/30.38)	IDIPsvaprfadnkPADFAPWT.GSQPEDVLSEQTAKQGFY.DRVQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09249 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHPSSHRPPSRPAPPSSGPSAPSVHHATPDVPQRVDCSSQQNVVIDLTEPEFSDTADIGRPAKRLRLDTGNEPPSASLDYHQQQHQQQQQQLQLQEQQQQQQYQNQSNPEHQWPSTAGEAPEISMNPLDLMNASSTEQTARPPWSFGTVIPRPGAEGQPELSQWPQPASLPPLPLRPWKYGPQERYLASTPKPKDGMEGGEVQTTPYHIDIPSV
1
216










Molecular Recognition Features






MoRF SequenceStartStop




1) LRPWKYGP
177
184