<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09248

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMDGTSAIGPGQENGQQLVDGTFSTTAPLAPNNNVNYSNGPVHAKDVNSLSSASFGDDSLPPELVHISQGFFSLGHLINRAAQQCWNDLTDLIAHLADPQTDSSNPASQAASAPITTTNGKYRPSSTSAAENAQRKLRILEFAQAKRADFIKILVLSQWSRRAADVGRLIDIQAFIRMRYDCYNGAILSVGEMKRDLIRAQTSNPDLGMALEVLSTGKVAAMQERAFIPPKRLTPKTMLKTLRKINKTIRTRLVLHDQVPSAFTNYIVHDGRVTFKVPTEFEVDLSIAQESHSSQFFFVDIRFLFSPSPPKPTGRLLDELDSKVNAMLMHSGLTGCYNLLHNLVLSNKITILFHQAIELARGHWLDTLRVEILHRTLVVQYWINRPGAKSWIEIGIKAGRHRDRIQDGSTIESPVLGLRWMRDNKEVESKYIKFDSELLSMEAILRSVCAQHVSFLLQSTYARLSQGRLYASGALSVSLQTSMSEPGDCFFDVQLTKGRNLRVMIEPVSGAIIFRPTPLLLNRHDIDRSFERPIIDDILFRISRLRSAAVIEEVESLADTLGWETVNSRDIKSEDLRRIFPPNILRYVLFFRKSWECNWGVGYTCSMDGDNWWVVELRAPSSDNNGPLSPQSARMVTGRFGGLPQRLNYGSFGLLDRALSGMLAIHANAHYLSELHGIHHFPPLRNLYLGPQLQVPSVSIRFRSSSLPLALQISPSIATNNDPPIRDTIRVSFRGIDPSSQFAILLARGHLSREVKDLGLLAAHLDPSITFQPNGCGFAMRFLTPVGRPMIIQLLARLQQLERVISTLETLKRKSLKPLSVTLSRIKFAYAAGEDTLASIDFNYHEQAISSDIDSITLLSKQSPLMLLRMSIDFHPQNPHRRIKESLTNTLNGQRFGAGTGAGLEAVLQLLAITLPILKALDRISIDTRTGKPGNSRLQITTRSSKVFYLRYPSIRYRFCIHAALRRDRVVWVLDMTIASDKTGREPLESKLKEQIYSVHGDGWQGLDNGAIADCEKVGNLLSTLHGAVDEYISSEVGGDLGMDKLGTRNGWSGGDAGGAGGGGGGSSSGLEGQKADQTNTASRGTADNNLNPNPGQTGVGMGTGMAMGMGIGMGGPKGLAAASNGMQMTTQTQTDMKAEKQNMKSAQNNKNNTAARNMANGNGNNGSEVDFIMID
Length1180
PositionTail
OrganismEmmonsia sp. CAC-2015a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia> unclassified Emmonsia.
Aromaticity0.07
Grand average of hydropathy-0.233
Instability index39.60
Isoelectric point9.18
Molecular weight129759.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09248
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     171.75|      43|      47|    1023|    1069|       1
---------------------------------------------------------------------------
  979- 1018 (30.08/10.03)	........DMTIASDKT...GREPLEsKLKEQiysvhgDGWQGLDNGAIAD...
 1027- 1069 (77.52/44.05)	STLHG.AVDEYISSEVG...GDLGMD.KLGTR......NGWSGGDAGGAGGGGG
 1073- 1119 (64.14/28.21)	SGLEGqKADQTNTASRGtadNNLNPN.PGQTG......VGMGTGMAMGMGIGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.36|      39|     153|     154|     193|       2
---------------------------------------------------------------------------
  154-  193 (65.78/49.85)	FIKILVLSQWSrRAADVGRLID.....IQAFIRMR..YDCYN...GAILS
  302-  350 (56.58/37.42)	FVDIRFLFSPS.PPKPTGRLLDeldskVNAMLMHSglTGCYNllhNLVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.31|      43|      47|     721|     765|       3
---------------------------------------------------------------------------
  723-  765 (74.11/47.25)	TNNDPPIR...DTIRVSFRGIDPSSQFAI..LLAR.GHLSREVKDLGLL
  767-  815 (61.20/32.50)	AHLDPSITfqpNGCGFAMRFLTPVGRPMIiqLLARlQQLERVISTLETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.83|      15|     153|     703|     721|       7
---------------------------------------------------------------------------
  688-  702 (27.14/23.98)	LRNLYLGPQLQV.PSV
  706-  721 (21.70/13.94)	FRSSSLPLALQIsPSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.59|      22|      52|     862|     883|      10
---------------------------------------------------------------------------
  862-  883 (40.99/28.18)	LLSKQSPLM..LLRMSIDFHPQNP
  914-  937 (32.59/20.78)	LLAITLPILkaLDRISIDTRTGKP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09248 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADPQTDSSNPASQAASAPITTTNGKYRPSSTS
2) DKLGTRNGWSGGDAGGAGGGGGGSSSGLEGQKADQTNTASRGTADNNLNPNPGQTGVGMGTGMAM
3) IMDGTSAIGPGQENGQQLVDGTFSTTAPLAPNNNVNYSNGPVH
4) PKGLAAASNGMQMTTQTQTDMKAEKQNMKSAQNNKNNTAARNMANGNGNNGSEVDFIMID
101
1048
5
1121
132
1112
47
1180










Molecular Recognition Features






MoRF SequenceStartStop




1) EVDFIMID
1173
1180