<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09245

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPAGALTNFRAIDGFFHIFWRIYSRVASESPGSQFDSLESSALRNSNEIRSSILALRNIGCLVSQLAKRCDLWIFSTDPSFDALRQVSRSRKPGEDLIVVGNVTFLNAASGVNTAAEIKHRLLSDPESSIFNSTTTQNNFRPSLSECSQLQHLATYSAFYEAFISATSKALTLNFAKRQKVIPLGTRTLYSSLDENRNQSGENGSPCAQKSTSFLSTLDINMTSKGRLVISLSTLPQPGLEQLRLGSESDKTATSLNEDLWLAPSGLLCRLTSIDEYQSTHSNIFSSSQVGAAHEAGLPAGKNVANTREWKKTVTEWLKIFGLYLNDPETELWVRVEINALDRPFYDTFSKSTWNHRTAPPFIQILWPAKLCFTRSHSKVTAPINPTEFFSGQAESPLQFAERCINEPFPMSQPLGLNKSSDGSSELEKQLLKPSEPSPLRLDRPDIPESLAKTINLPEAQLASAVYPTPPGGALTQNIGTNIVSEVLGASTTDALNTDALNYPSTQSESVYNEASGSTAYFRGNSELLPHNLDGASSELGIGSGLYDTAADEDFFGDMDVANFDSKGITEADFNFFDEPDFAGLTGDLDMKTGEPETRQQHAESNLDTPYNSNTAMSRAEPDRSNTDRSHPLTTSNDGVCMKHSTVGPLVATAAESQISGGAAEFRPVSSTHGPRKRPISPPLSPVQIKKILSPDVPSLLKSKSELSELSKIRAVQNQYSPVIFQPKLWSSDKKYKLDGRFWFTPGRAHVTSNLGSYPSDIPTIGFPEKGRNGRPKPPPIRMSSASNNVPEAELQSPSTSSFDSSDDGSGTDRGSNASSPRIGASFRPKRKRDYEGGGNSTPSSLEGHTHASHEDITPLNEHQLALLGIFLSEAVDWPLTGYFSRKKNDVFPVFSRREDLLQVAQLVVDQITQSSLLHIHDDLHKPEWVDWDDVLSRSLFDNNDGLGHMSRLDLRSYATLEDGPNSRKEMPSIRPNIAGSICKICCPHVKVHRGNDYLEILPPATGFWETFGLEPLQGEKNIIPFCIYPPNVTEAADAFMDRLGLVYSSGNFGSHTRPNKVNGLVPWSLNAASDQDYTSLMHALNVSCENLGSALSNISATDANVVIYIINPFVYDAAIVDICSAFLRLFHKYVGDVDRHHTRQLNELVLQIIPLEFIASPDSLVVPTQMDYLRLALEVYSRCPPKDRSSDWLGCAPPLVLADPVPRVVPFRLVSESVVPLEEAKCLHVAYSQSVDQRWVTAAWTDNSGRHQTTLSYCLRERDSPVSRSISEIRTQIWETSKDIMDMSSSHWRFMVVKDEPVGSDEVEMWKSLLDQYNRDKTIKVELGIICINTKPGLSLKLPSSPLQLSALSQQSTQNGPSTTTPGSTPRPVPSPDPSGPAATPPTANTPIFADQQQPTPQQTQQPSPDSDLDTILIDKSDETWGVTLSHRLNSSYSLTKYQPALASGYLFRRSGTSDTDGQAVMTVNIIYTNSRRPIDHFLKDILRMYRELATLAQARGIVHAQGNSHYPGIS
Length1518
PositionKinase
OrganismEmmonsia sp. CAC-2015a
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Ajellomycetaceae> Emmonsia> unclassified Emmonsia.
Aromaticity0.08
Grand average of hydropathy-0.413
Instability index51.34
Isoelectric point5.55
Molecular weight167062.00
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09245
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.72|      28|     100|     720|     752|       1
---------------------------------------------------------------------------
  720-  752 (51.05/39.19)	NQYSPVI...FQPKlwssdKKYKLDGRFWFTP....GRAH
  819-  853 (44.68/23.36)	NASSPRIgasFRPK.....RKRDYEGGGNSTPssleGHTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.97|      64|     767|     286|     482|       2
---------------------------------------------------------------------------
  406-  472 (103.51/185.00)	CIN.EP.....FPmSQPLGLNKSSDGSSELEKQLLKP.SEPSPLRLDRPDIPESLAKTINLPeaQLASAVYPTP
 1334- 1404 (102.46/14.76)	CINtKPglslkLP.SSPLQLSALSQQSTQNGPSTTTPgSTPRPVPSPDPSGPAATPPTANTP..IFADQQQPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.79|      59|     767|     286|     349|       3
---------------------------------------------------------------------------
  286-  349 (93.97/80.39)	IFSSSQVGaAHE.....AGL.PAGKNVANTREWKkTVTEWLKI....FGLYL.NDPETELWVRVEINaldRPF.YD
 1049- 1119 (80.82/53.41)	VYSSGNFG.SHTrpnkvNGLvPWSLNAASDQDYT.SLMHALNVscenLGSALsNISATDANVVIYII...NPFvYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.10|      26|     361|     578|     603|       4
---------------------------------------------------------------------------
  578-  603 (48.87/36.42)	FFDEPDFAGLTGDLDMK...TGE..PETRQQ
  942-  972 (37.23/25.60)	LFDNNDGLGHMSRLDLRsyaTLEdgPNSRKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.63|      29|     609|     637|     675|       7
---------------------------------------------------------------------------
  536-  566 (43.89/18.28)	DGASSELGIGSGLYDTAADEDFFGdmDVANF
  640-  668 (50.74/50.07)	DGVCMKHSTVGPLVATAAESQISG..GAAEF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09245 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTGDLDMKTGEPETRQQHAESNLDTPYNSNTAMSRAEPDRSNTDRSHPLTTSNDGVCM
2) MSQPLGLNKSSDGSSELEKQLLKPSEPSPLRLDRPDIPESLAKT
3) PSSPLQLSALSQQSTQNGPSTTTPGSTPRPVPSPDPSGPAATPPTANTPIFADQQQPTPQQTQQPSPDSDLDTIL
4) SNLGSYPSDIPTIGFPEKGRNGRPKPPPIRMSSASNNVPEAELQSPSTSSFDSSDDGSGTDRGSNASSPRIGASFRPKRKRDYEGGGNSTPSSLEGHTHASHEDITP
587
413
1346
755
644
456
1420
861










Molecular Recognition Features






MoRF SequenceStartStop




NANANA