<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09213

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAVELGQQMVELGAMVRLAAEESYLALRDLVEMSRTEAEAEAQGKEGVRLRSDTEKKIDLLKFVDRTRQRMLRLHVLAKWCQQVPLVNYCQQLASTLSSHETCFTQTADSLFFMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQNTLFQDERRPTLKILNTLVRAKLLETSLPKEISEVSVTDGIANLCVHGEFKVLLTLGYRGHFSLWRLLHMELLVGDKTGPITLEETRRYALGDDIERRMANTDNPLMILYTVLHELCISLVMDTLIRQANILRQGRWKDAIKSELISDNSAAQVGNNAPVQLGQDGELDQSGFRIPGLKVNYWLDENISGSTEPDVSPFISIEAGKDMRINCLHSSFILDPLTDKEVDLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNVQISQSPADVVLKREVIHVDSLGKKVDGSNFGNCTNEVLQVRAYGQLYIHLGINIRSGRLLLQSSKNILLPSALLESEEALNKGSLTASEVFVSLKTRSILHLFAAIGRFLGHKVYSQSQVPLKIPKSVLYGSDFTVMGFPQCTNAYYLMIQLDNDLTPVFHLLETQTDESNKSSTDSTTDANQAVRFNRINISHMQIGEEKYSLNLFDSEKPLEHMVNYNQCIEGRNVKLLPLTPSLSPSFSSLVDEVFEHNLSSSTTENQLLPPHSLASNHLNSYQVGAVGVSGTVCPPELDGNFMHSDINFSEVKPGVSLNSDLLSNLNHFKCTNAISSSGTAHISLMSSNCKSGHDLTSLRSSGGHNIVHGGESLQPVSSDGQGVLGNTSTMQFGGSSRKRSLSEFLLSIPSLQQSRISEGPRKRRKAPEHMKDGILFKEYSSSAQSGKTVTYGNIFTEEKCCITSAFYASLLCRVIKHCSHLIKYAQLTTQMDSLGISYAEEVVLWTPSSNLCLRLPFLKEDSWKHVCLRLGKSGCMSWDVRINDPYYGSLWKVHGGSATTEWGIGVCIAKTSEIDSHITFDDDGVVLTYHTVEADSIRRLVSDLRRLSNARAFCCQMRRLIGVKVDDKRDEKATSVEINARKGSRHRLSEQMRKTFRIEAIGLMSLWFSYVVVPMVHFVVEWKAGDGGCFVHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLAFSSAIRPAKMPVTLPAGYSSVPKQNSYRSEGASANGSSTTVQNTSAPLNPAVAHSNKHNLQSSVLTIAGRGGPGLVPSPSLPFDVTVVLRGPYWIRVIYRKIFSFDIRCFSGDQVWLQPATPPKGGPSIGGSLPCPQFRPFILEHVAQGLNTFEPSVMSARHSSVQLKASINKASGGQQSALALNRFHGAHGIATSGPTTNVGNQVAPTFIRADSTVVASSKYASGNAGAPPHLSPGINLPVHMRSELSSTLTAVGDDGGYGGAWVPLAALKKVLRGILKYLGVLWLFSQFPELLKEILGSVLNENEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLLLQVLNVKRFHHHQQKNQQQAQSPAQEELATSEINEICDYFSTRVVCEPYDASRVASFVTLLTLPIPVLQEFISLLVWKKSQSQVHGEIASAYRVQVELCLETHHGSVSNDHAESLSSSKSNIKHDRANRSVDFGLTFALDHTLKHNSSVGGAAWLPYCVSVRLRYTFGDNCHVTCLAVEGSHGGKSFWLRYEDWENCKQMVARTVETANESPAIGETGKGRLRLVAEMIHKQLQLSLHQLTLPAG
Length1727
PositionTail
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.07
Grand average of hydropathy-0.159
Instability index49.67
Isoelectric point7.12
Molecular weight190619.13
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09213
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     403.62|     149|     399|     965|    1252|       1
---------------------------------------------------------------------------
  327-  409 (89.83/15.24)	RIPGLKVNYWLDENISgSTEPDVSP....FISIEAGKDMRINC..LHS...SFILDPLTDKEVDLSI.DLSC.IDVEALILKAiacnrHTRLLE.......................................................................................
 1032- 1206 (219.51/357.29)	RLIGVKVDDKRDEKAT.SVEINARKgsrhRLSEQMRKTFRIEAigLMSlwfSYVVVPMVHFVVEWKAgDGGCfVHVSPDQLWP.....HTKFLEDFVNVGEVASFLDSIRLTAGPLLAFSSAIrpakmpvtlpagyssVPKQNSYRSEGASANGSSTTVQNTSAPLNPAVAHSNKHNLQSS
 1524- 1600 (94.28/19.50)	.........................................................................................TRVVCEPYDASRVASFVTLLTLPIPVLQEFISLL...............VWKKSQSQVHGEIASAYRVQVELCLETHHGSVSNDHAESLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.89|      14|      16|     765|     779|       2
---------------------------------------------------------------------------
  765-  779 (21.08/16.43)	GHDLTSLrSSGGHNI
  783-  796 (24.81/14.13)	GESLQPV.SSDGQGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.88|      33|     399|     965|     997|       3
---------------------------------------------------------------------------
  965-  997 (61.09/37.65)	KVHGGSATT....EWGIGVCIAKTSEIDSHIT.FDDDG
 1365- 1402 (48.79/28.54)	KYASGNAGApphlSPGINLPVHMRSELSSTLTaVGDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.49|      33|     180|     525|     563|       4
---------------------------------------------------------------------------
  526-  558 (60.00/32.24)	RFLG.HKVYSQSQVPLK.IPKSVLYGSDFTVMGFP
 1423- 1457 (45.49/20.20)	KYLGvLWLFSQFPELLKeILGSVLNENEGALLNLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.92|      22|     399|    1214|    1252|       5
---------------------------------------------------------------------------
 1214- 1252 (28.43/47.42)	GGPGLvpspsLPFDVTVVLRgpywirviyrkiFSFDIRC
 1632- 1653 (45.49/24.34)	GGAAW.....LPYCVSVRLR............YTFGDNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.69|      55|      78|     559|     616|       6
---------------------------------------------------------------------------
  559-  616 (88.80/84.53)	QCTNAYYL.MIQLDNDLTPVFHLLETQTDESNKSStdSTTDaNQAVRFNRINISHM...QIG
  639-  697 (86.89/69.60)	QCIEGRNVkLLPLTPSLSPSFSSLVDEVFEHNLSS..STTE.NQLLPPHSLASNHLnsyQVG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09213 with Med14 domain of Kingdom Viridiplantae
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