<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09199

Description Mediator of RNA polymerase II transcription subunit 15
SequenceEDRIFAVVSCAIALLIFHSNFVTVFLHFPVNFHAENLLKIMSEDNSWRTPSFRQNVVAKINEAIQSSGMNTTKSSIEMENHVFVKARNKDEYLSFVARLILHVREMNTKNKMQGSCAGEVNNTSGMPDPINALQNLASQGSRPQQQMMGMGGPQGAGGPMGGPGGPQGSNIPASNLLQTLTQQQAPMQGMQQMQNQRPGGGGPGPMQNQMGGGGQMGMGMGGMNQGGGGGPPGPGGMPMGPGMNAGVGPGGGPGGPGGPGPMQMNPGGIQGQPGQMGQMGGMGQMGMNPGMSQAQMGNAMTPVSMSQAGGMGPQGGGPMGGPMNAGPMGGMGPMGPGMMGPMTTGANVVMQPNQQGGMNPAITTQGGGMGPNAGQMNPAQLVGMQQMARKGPEMMMTQQGGVFPGVRSVTPNQFLRQSPSPSVPSPASMGQPHQQGMVPSPAMVPSPSPQSMAQGPPRSMGVMSQSPSSTLNTPGQASVYSPLNPQEDLLYREKYRQLTKYIEPLKRMIARMVNDKNNGNLQKMNKLLEILCNPNQRIPLETLLKCEKALEKMDFKTNVLGPVSAQGANAKEHPINNPLLEAVSANLQNPIGNHTLQRTFRPCLEALFGPDIKNLPPPAKQARLSSPEEPPAATSGPEIPHTLQGEIARLDQKFKINLDPSAQMGTKTIKLVCCLDDKYLPCVPPVCVSIPEDYPKTGPTCNLLEQEYNATPFLVAIQKALTARISKLPRDFTLSHLLDSWELSVRQACAPVQVKPSQTTVLLGI
Length765
PositionTail
OrganismLutzomyia longipalpis (Sand fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Lutzomyia> Lutzomyia.
Aromaticity0.04
Grand average of hydropathy-0.402
Instability index50.63
Isoelectric point9.08
Molecular weight80564.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09199
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     515.35|      55|      55|     186|     240|       1
---------------------------------------------------------------------------
  129-  174 (80.94/17.13)	PIN..ALQNLASQ.......G.SRPQQQMMGMGGPQGAG.GPM.........G..GPGGPQG.SNI..PAS
  186-  240 (130.11/32.22)	PMQ..GMQQMQNQRPGG..GG.PGPMQNQMGGGGQMGMGMGGMN.....Q..G..GGGGPPGPGGM..PMG
  261-  306 (72.35/14.49)	PM........QMN.PGGiqGQ.PGQM.GQMGGMGQMGMN.PGMS.....Q..A..QMGNAMTPVSM..S..
  307-  340 (57.79/10.02)	...............QA..GG.MGPQ.....GGGPMG...GPMN.....A..GpmGGMGPMGP.GM...MG
  341-  377 (50.47/ 7.77)	PMT.............T..GA.NVVMQPN....QQ.....GGMNpaittQ..G..GGMG.PNAG....QMN
  378-  430 (69.07/13.48)	PAQlvGMQQM..ARK.....G.PEMMMTQQGGVFP.GVRSVTPN.....QflR..QSPSPSVPSPA..SMG
  433-  483 (54.62/ 9.05)	HQQ..GMV......PSP..AMvPSPSPQSMAQGPPRSMGVMSQS.....P..S..STLNTPGQASVysPL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      46.84|      10|      26|     516|     525|       2
---------------------------------------------------------------------------
  516-  525 (16.44/ 9.02)	KNNGNLQKMN
  535-  544 (13.88/ 6.46)	NQRIPLETLL
  545-  554 (16.51/ 9.09)	KCEKALEKMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.27|      46|      53|     600|     652|       3
---------------------------------------------------------------------------
  560-  598 (49.81/21.98)	..........LGP..........VSAQG..ANAKEHPINNPllEAVSANLQNPIGNHTLQ.......R
  600-  652 (80.34/51.62)	FRPCLE..ALFGP.........DIKNLP..PPAKQARLSSP..EEPPAATSGPEIPHTLQgeiarldQ
  654-  699 (38.11/13.34)	FKINLDpsAQMGTktiklvcclDDKYLPcvPPVC...VSIP..EDYP..KTGP...............
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09199 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NKMQGSCAGEVNNTSGMPDPINALQNLASQGSRPQQQMMGMGGPQGAGGPMGGPGGPQGSNIPASNLLQTLTQQQAPMQGMQQMQNQRPGGGGPGPMQNQMGGGGQMGMGMGGMNQGGGGGPPGPGGMPMGPGMNAGVGPGGGPGGPGGPGPMQMNPGGIQGQPGQMGQMGGMGQMGMNPGMSQAQMGNAMTPVSMSQAGGMGPQGGGPMGGPMNAGPMGGMGPMGPGMMGPMTTGANVVMQPNQQGGMNPAITTQGGGMGPNAGQMNPAQLVGMQQMARKGPEMMMTQQGGVFPGVRSVTPNQFLRQSPSPSVPSPASMGQPHQQGMVPSPAMVPSPSPQSMAQGPPRSMGVMSQSPSSTLNTPGQASVYSPLNPQ
110
486










Molecular Recognition Features






MoRF SequenceStartStop




NANANA