<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09194

Description Uncharacterized protein
SequenceMPPLSDEFGTAHTSNVNASKVASFFNAILAKKEELMTLQDTVRKKQQINFKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTGNLIKFMKELLPKLQEYYHLCEKSSSSEKALLSGQGAPTTQNNNASLTLSHSSNNATLVPSIASPVPMLSPANSQSSSSGGLGVLSSNSGSGVGTSSSQSSITGANQTPVSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRMEFLNWILELLDRMRTQANFDESLKRLVLTFALPYMQDFVQSERLCRKMAYIVAKKLTNLLNAVIDQQQSLTNGKSENTMHMEMDEEIDKKKTQLDPYEVAINEYLNCPHHRDIILYLSTILQVITVECPTAMVWCGIGENRAPAALCGSPLDHLPVAPSVLPMPIKCPITNAEVRRQLRATEAEIVLRSKHAENRWFAEKWQNANKNSYTHVLSILDYLDTHCFDRMDQTNSIDSLYANIFKTFVTIRREVGPNGEIKEIRHEYDANVVDGTTVRILCEWAVSSQRWGEHRAIVVALLLDKRQIEVTTPNESDNNNGNAVAHSNNNLNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGGLTNRTQFTNLVHLFSALIRYDVFSHNAYMHTLISRGDLLEGVANVDSSKPSVTATTTVSGPVSNKASSPPGNQGFDDDFGTSMDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDTSNSIGCDNANSSISRHYIYTKHFPIPQDDPTTSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNAFALGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPELENQLQAKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFDGLCRTIKHVANPSECSSAERCILAYLSDLYESCFLLKSKEQEPEFFQQMAAIKKFKDIFNAPEQLGIVPQAYNPQFLQELFTSPKRGGKIDSIWLHQLHESPSNVYSFVSNAIVAVCHEADNDRLNDIAISCAELTAGCNALSEEWIAALQSICNAMKKPRYPHFCQVDIQNSKIHNSLAVFICILVARHCFSLADFVMNFALPTLANAYPVGGEISADAEAGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLTAVGSSSNIKLSCDRHLLIGAHKNVPLEAVLAVLKAILIVVDTTALKTSNMSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLSQILGTSDLNSLNTEHDHDMTQQLTSTPSNTGALNNSEQISLLEFAQHVLKQICAQEHVLERCLKNAEKLCDMIIDEMLTPKQVQRILHMICYPESEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHRQSMNNPAELSSWLDTVARAAIDVFLMEEVVVGSGLKSEHRPKASTWLVAPLVAKLTPAVQGRILRVAGQVLESMSYFSKVSKSDNNSSCSGDEREKSNSCGSASSSYSIGVNGSNSRSRKMPLNYQPFLGLILTCLKSQDEYKEGLLCSLYSQLSQCLQSYTEFDTMGGVDDPLGREEMLDALQLRFSLVGGMFESIQKNGTSITDWAILLAQLVCQGVVDLSTNKELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEALPLPPEDIEPIAEKIVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTGHNPQQQQWPGQNQFHPMQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQSLGAQTPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNANIMASQNNTGLVSASAMMQQNVGVGGGAVGQNMVNQNAGQFQNFSQYQHQAINQSGNSNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGSVPPYSRQQTSGGKPGVVSTQQQFQQQQRLQHQMMQMQGIGPQNNGASSMTQPQNQTVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
Length2316
PositionKinase
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.436
Instability index47.96
Isoelectric point6.50
Molecular weight257259.29
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09194
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     144.13|      19|      19|    2080|    2098|       1
---------------------------------------------------------------------------
 1904- 1919 (24.27/ 7.03)	I.QQQMNVG..NSQQSSQM
 1951- 1967 (31.47/11.31)	MQQQQ..QQQFYQQQQQGM
 2029- 2047 (25.58/ 7.81)	VQQQQLQQQQFARSGMRSM
 2080- 2098 (37.36/14.82)	IMQQQISAQTMNPQNNNQM
 2258- 2273 (25.45/ 7.73)	MQMQGIGPQ..NN.GASSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.85|      17|      19|    2147|    2165|       2
---------------------------------------------------------------------------
 2099- 2113 (21.06/ 7.60)	IMNQNAG.V..MSTGNNQ
 2148- 2165 (28.79/12.98)	MVNQNAGQFQnFSQYQHQ
 2298- 2312 (28.00/ 7.98)	MLNQPNMMGQ...QYQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.62|      19|      19|    1975|    1993|       3
---------------------------------------------------------------------------
 1970- 1988 (36.69/24.70)	NRFERPPHMSNSRQAIHNM
 1989- 2007 (35.93/23.99)	LRHRQPPMNQNNSAAFNTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      15|      19|    1064|    1082|       4
---------------------------------------------------------------------------
 1064- 1082 (21.38/19.90)	GIVPQAYnpqfLQELFTSP
 1086- 1100 (28.66/14.51)	GKIDSIW....LHQLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     158.44|      26|     247|    1878|    1903|       5
---------------------------------------------------------------------------
 1878- 1898 (33.98/13.47)	..................................NSNQMMQQNPNAI.IQQQ.QQMP
 1899- 1943 (33.10/12.91)	GVPSG........iqqqmnvgnsqqssqmgfmgsNGPQGMAQTGHN...PQQ.QQWP
 2138- 2192 (27.46/ 9.35)	GVGGGavgqnmvnqnagqfqnfsqyqhqainqsgNSNQQANIVANFM.AQQQ.QQQP
 2196- 2223 (33.80/13.35)	G.PAG..........................mtsNRGQYMSQAPNVT.MNST.MGQG
 2224- 2251 (30.10/11.02)	SVPPY.............................SRQQTSGGKPGVVsTQQQfQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.89|      14|      25|     165|     178|       6
---------------------------------------------------------------------------
  165-  178 (22.71/13.62)	SSSEKALLSGQGAP
  192-  205 (23.18/14.08)	SSNNATLVPSIASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.70|      21|      22|     214|     234|       7
---------------------------------------------------------------------------
  214-  234 (37.08/21.23)	SQSSSSGGLGV.LSSNSGSGVG
  238-  259 (32.61/17.71)	SQSSITGANQTpVSGSSISGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.03|      30|     408|     494|     527|       8
---------------------------------------------------------------------------
  494-  527 (47.91/42.76)	NA...NKNSYTHVLSILDYLdthcFDRMDQTNSIDSL
  906-  938 (49.12/31.65)	NAfalGSNNYLPVQEHVAFL....FDLMEMALNIHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.47|      20|     128|    1645|    1664|      11
---------------------------------------------------------------------------
 1645- 1664 (35.29/24.28)	GVDDPLGREEMLDALQLRFS
 1775- 1794 (35.18/24.19)	GVDQKGNKINDMDKKQLRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.21|      27|     470|     759|     807|      12
---------------------------------------------------------------------------
  765-  797 (38.46/63.73)	KEKGQAEAPDSpkipdTSNSIGCDNANSSiSRH
 1570- 1596 (47.75/17.37)	REKSNSCGSAS.....SSYSIGVNGSNSR.SRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.28|      20|     421|    1431|    1462|      13
---------------------------------------------------------------------------
 1443- 1462 (35.75/34.94)	ISELDQRSMIVRILEN...LGQW
 1466- 1488 (33.53/ 9.93)	ISWLDLQLMHRQSMNNpaeLSSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.93|      85|     250|      43|     135|      20
---------------------------------------------------------------------------
   43-  135 (127.69/117.56)	RKKQQINFKDNFWPVSprTKGALdAWFKDLAGNKPLLSlaKKAPSFNKKeeiLITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDP
  303-  387 (142.24/102.61)	RMRTQANFDESLKRLV..LTFAL.PYMQDFVQSERLCR..KMAYIVAKK...LTNLLNAVIDQQQSLTNGKSENTMHMEMDEEIDKKKTQLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.10|      10|     177|    1330|    1339|      25
---------------------------------------------------------------------------
 1330- 1339 (20.14/11.81)	GSTPKSNERP
 1508- 1517 (19.96/11.63)	GSGLKSEHRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.06|      13|     419|    1293|    1311|      30
---------------------------------------------------------------------------
 1293- 1305 (21.50/23.86)	VVDTTALKTSNMS
 1312- 1324 (23.56/ 7.76)	AFGTTGGKRSGFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09194 with Med12 domain of Kingdom Metazoa
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