<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09187

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTELNGKNSIIRNPNLSKSRVFIGNLPICTKEELESIFLPYGKVLGSLVQKNFGFVQMESEEVANRVASALTKSTFKGNTITVRNAGIHKKQLASDANVSLSASNVNSTRQTKSTGPSIHNSIGNCNDCEIIVVDRRNTKYAEMIEERLKFLHLRVDVLFPNADVPLGKVLSNIASRGCLYAILITTQHEEHRSITVNILHGQPAEHRNMPVDDAIKLIDEDFRKSQRSKTQQRIIAAGNSSTLHLPQSVPIIPAVASYVVPPLKERHPDAIQTLLDLLADNLPLTVLQYDRIIKYLQERRELQMKVELGDAAEEVNTNVPDPEIELQKKILNILNKPSVAETHYDLLYPSLQAVKEDARLLELLKDIRVQKALDALMDTNLLSTTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRIQSTKQDNSDLNALGDEVNNTKVHPPLSLAAAKELWIFWYGEEPDLTDLVDAELLRVAANQATWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQDQTSPNNSPIVAEAAGENSAANANGSNMPKPRKVILAPFGMAATLTGNSYRANDPMAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNTGDNLSSNVRKPLTETVSNKLTTNTNQTASSKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANAAIPANFNENISVIGNGGSNGGSGGGASIGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTKSLAAQHHHPAAATTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPASVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNIIGGAGGGGGGGGGGGGGGVVGVAVGGPNLNENIQSSGIGGGGGGGTNQPASVGRCTPTIQQQQSSQQHQQQQQPQPQQQQHQHQQQQPQQQHSHQQQQCGTITVKRFDLQPTLPATVVGFSANVVASAGDVKLESSGLQLNPTVSSASSTSHSHSHSTTTLNAMLPNSLKRNSSTQGSAGNSIHAMHDFLNLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSYHTIKRFKPNDLSKPCRIMRTKNLYEGHTHIKPLMPSPRSVYGNQLLAADSVQAAQMTSASGSDSSTVMADMSGGLVGIASNNQNISRLANDNSAGPLTAVGSSTTSNFFEELDIKTEMMSGTASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAISNTAIDELKRSTNPAILANSNVAIANSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGPNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSKYAPLTNLPSQTMAPLIAPPNCIYKPSWQPTRSTHQQPQQQQQLQQHNQSLQQQQNHQQQQPQHQQHQQLHELLSSAPRTPLQQPRTPLGPMSSSPMHNTVPTPLSSGGGGGGSLLLNQLNCPQAALTNTPSAMQQLMQRAGMSPVSPAPHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPSASLGLFSGTVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGVYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFTSKSNGTNGNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTTIANVLEYMDANDIISLALEQARLAFDSSRVDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYMPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTLMCGWGGMLTVSQRPPTEKPYTTNMDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPNDKSLLNPPDANIHAGSHNNTRLNASGNTSSPMAGTITGLENSERGDHASSTPMEHGDLSQHATTDTSANINDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPESVRANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDDQNRRPYKMYTPPYILAPIHEKNEKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVLGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPSWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length3031
PositionMiddle
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.406
Instability index52.12
Isoelectric point6.12
Molecular weight328971.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA binding	GO:0003723	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09187
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.90|      16|      27|    1039|    1060|       1
---------------------------------------------------------------------------
 1043- 1058 (35.93/16.06)	HNIIGGAGGGGGGGGG
 1715- 1730 (32.97/ 7.89)	HNTVPTPLSSGGGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.80|      22|      22|    1102|    1123|       2
---------------------------------------------------------------------------
  993- 1012 (28.70/ 9.54)	..QQ....PPTP...................IE..HLLDKNTPAPTP
 1114- 1137 (44.79/19.09)	QQQQ....QPQP...................QQqqHQHQQQQPQQQH
 1656- 1674 (34.17/12.78)	QQQQ....QLQQ...................HN..QSLQQQ...QNH
 1781- 1825 (23.14/ 6.23)	QQRQtpihPPPPyevavaspalssasstaayIN..KQYHSQEPPHTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.91|      13|      22|    1059|    1073|       3
---------------------------------------------------------------------------
 1059- 1071 (25.80/ 7.44)	GGGGGVVGVAVGG
 1957- 1969 (26.12/ 7.67)	GGGGGGIGSALDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.39|      21|      27|     923|     948|       4
---------------------------------------------------------------------------
  921-  946 (22.46/25.01)	GH..GTPlqGAnGgASSYSRNSVMdTMP
  947-  969 (37.93/16.94)	VPsvGSP..GT.P.APSPHPNSTL.SQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.50|      24|      27|     565|     590|       5
---------------------------------------------------------------------------
  551-  581 (35.54/16.75)	QHLSFSFtffvhgdTVCASID...LREHPAVRPL
  584-  614 (31.96/20.54)	EHLSEAA...aaftTVAASSNnsqDQTSPNNSPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.92|      18|      30|    1452|    1481|       6
---------------------------------------------------------------------------
 1454- 1471 (32.17/ 9.24)	NPSNGCAISNTAIDELKR
 2061- 2078 (32.74/ 7.55)	NGTNGNGVMDKAADQLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.52|      28|      31|    1883|    1913|       7
---------------------------------------------------------------------------
 1883- 1913 (44.18/35.12)	DTALNV.FRDHNFDSSTVCvcnADSQRIGNIR
 1916- 1944 (44.34/26.00)	DSGVYVpLPGTSFNPSPLT...SSATTVGNIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.75|      22|      31|    1233|    1263|       8
---------------------------------------------------------------------------
 1233- 1263 (33.89/45.22)	DFlnlykppkiCVKD......IDSFANDD....C..LKLDVLY
 1264- 1297 (25.86/14.67)	DF.........TVQDawsyhtIKRFKPNDlskpCriMRTKNLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.93|      26|     865|    1080|    1113|       9
---------------------------------------------------------------------------
  853-  873 (34.08/10.99)	.....GGSNG.....GSGGGASIGDCGGEQQ
 1080- 1105 (49.41/39.00)	SSGIGGGGGG.....GTNQPASVGRCTPTIQ
 1984- 2009 (26.44/ 8.22)	PSTTTPASNGqqhitGYVDDDSV.ECT....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.47|      16|     865|     878|     912|      10
---------------------------------------------------------------------------
  894-  912 (24.53/45.64)	DPTQKAPcicTKSLAAQHH
 1533- 1548 (32.94/13.46)	DLTKMFP...TPPSHEQHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      19|      22|    1180|    1198|      11
---------------------------------------------------------------------------
 1180- 1198 (35.66/18.64)	SSGLQLN...P.TVSSASSTSHS
 1201- 1223 (22.50/ 8.66)	HSTTTLNamlPnSLKRNSSTQGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.93|      19|      21|    1332|    1350|      12
---------------------------------------------------------------------------
 1338- 1357 (27.89/13.93)	STVMADMSGG.LVGiASNNQN
 1359- 1378 (25.04/11.67)	SRLANDNSAGpLTA.VGSSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.33|      21|      33|     393|     413|      13
---------------------------------------------------------------------------
  393-  413 (38.31/22.79)	WRKFVNSERPNASSDPLDDPI
  429-  449 (36.02/20.91)	WRRIQSTKQDNSDLNALGDEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.78|      31|      33|    1589|    1621|      14
---------------------------------------------------------------------------
 1589- 1621 (52.84/34.11)	ELGSPIEEP.IEDWSYVYRPPQQAkfVGSSKYAP
 1624- 1655 (56.94/30.93)	NLPSQTMAPlIAPPNCIYKPSWQP..TRSTHQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.05|      11|      27|     734|     748|      16
---------------------------------------------------------------------------
  734-  748 (14.87/15.60)	LTTlssvNTGDNLSS
  762-  772 (20.17/ 9.71)	LTT....NTNQTASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.26|      16|      32|    1482|    1497|      18
---------------------------------------------------------------------------
 1482- 1497 (25.18/16.94)	NVAIANSTAGAAVMVA
 1516- 1531 (27.08/18.93)	NNSVGNISGGANIIQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.81|      16|      22|     802|     818|      19
---------------------------------------------------------------------------
  802-  818 (26.52/18.60)	CNTTNTHApPQAATEMP
  825-  840 (29.29/15.20)	CVTNSLHA.QYANAAIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.98|      17|      22|    1677|    1693|      20
---------------------------------------------------------------------------
 1677- 1693 (30.84/18.03)	QQPQHQQHQQLHELLSS
 1696- 1712 (31.14/18.29)	RTPLQQPRTPLGPMSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.37|      15|      22|     659|     673|      21
---------------------------------------------------------------------------
  659-  673 (28.20/17.83)	PMAEKILEDWASFFP
  684-  698 (28.18/17.81)	PVVEVISGGHKMYHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.91|      10|      31|     458|     467|      24
---------------------------------------------------------------------------
  458-  467 (16.89/ 9.69)	LSLAAAKELW
  486-  495 (18.02/10.88)	LRVAANQATW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09187 with Med13 domain of Kingdom Metazoa
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