<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09183

Description Uncharacterized protein
SequenceMAPAPQPLEQALAGYLPQGQEGSSRMNTISLSVLIDFTIQRTYHDLTVLAELLPRKSDMERKIEIYNFSARTRQLFIRLIALVKYANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDPITPQEKKQTLLRLNQVIQHRLVTGKLMPQMREFKIRNGRVIFEVKHEFNVSLTVMGDNANVPWRLLDIDILVEDKETGGINIKKKMKEKVKLDFKFLDGKALVHPLQVNYIHQLIQVRLVENPNALCEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNINVEEYIPGYKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIMPEMQACLNGDRSKLPQIMTELRYWITHRRCEKTLQHLPATATENLTFLNMPDHPLLQSGRHKIYVKLHRHPNVVLVVHLKEKSSMPNEMEYTFYLGLLVYQSNETEVLSEDLTKQLVPVQTSNSNVENHGSHHHEIPKVFAKLLRLIEFDTFVATHGPGTDVDDVPPHKRKSNSELTAPPTKQAKTIYPAYIIPDLAHVVAMCDEKIPFLNLAQALTKYNVPHCGLQVESNAISLVLKIITLPQPTPPDDRKFPVIESNVWDDLMKRVLSISIRSHMNKSNKIRSWVMEFIFYSTPLQSVHPREQGNRRTLYLSYDQISNYSQTVEDLLKDWSKIVYLYTLVYSFAEHIKNKRLNITDMLSINSYNYTNLLLGYGPKKEVLCNIFWSAPVGGFHMTFLGGITAVNAHSVIRDQLAIYLNTKHNLTQIVQLLHETYNPLSSIAKLPIIPHLGIPRPQVPVLSFCILPQSPCVIRLAYQAVYCLEIRFRSGRLISIRDGAYSRFDRNLIEEFTPIQGLKGFLSKYVDENAVYRGRSQNEDDNPPSPIGGEDNFGGTSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSAINQNTNSGSGSSSQVINRMPPPNRSYAGAVPTLLTHEKFDLLCRPSPHPNKDITSTIDISPLERFLGCVYMRRQLYRNVQNEDTLTALNSNEPGVVLFKVDGLQCQVILNQVHMQSLHLKVNQLPPPHTPDSKQPFQLSPDDLLIIEKFFDTRVAAPPYRPNALHGFSRVLSCAPQVLKDFLQIMRLEMNPDLGGDQIKWTVQFCMRVPPSAAPIVPIGSPGVLMVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQPQSPAATAVSAVLRHFSDHLAQPGQCSLFPAVREILISLQLPNDVPPQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
Length1531
PositionTail
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.294
Instability index52.90
Isoelectric point8.80
Molecular weight171888.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      83.40|      18|      20|    1071|    1088|       1
---------------------------------------------------------------------------
 1076- 1097 (29.31/ 8.93)	TSPPGPHMPH.PSPgalmpssP...L
 1098- 1117 (26.51/ 7.40)	NPQPSPHMVHsPGP......nTLYMQ
 1118- 1134 (27.59/ 7.99)	GHQDSPFAAM..SP.......ANTNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     124.39|      23|      24|    1480|    1502|       2
---------------------------------------------------------------------------
 1052- 1070 (27.94/ 9.45)	PH........PS.AGGGVGTgSS...NAQSH
 1157- 1181 (25.20/ 7.74)	.QSS...AINQN.TNSGSGS.SSqviNRMPP
 1480- 1502 (46.31/20.92)	PQSQ...AIGPP.IGARVGS.SP...NPMMH
 1504- 1528 (24.94/ 7.58)	PMQQmggPVGPPqIGPGYPQ.MP..qNP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.19|      18|      24|     148|     170|       3
---------------------------------------------------------------------------
  148-  166 (30.03/26.28)	RLPTCIRERIVpPDPITPQ
  174-  191 (32.15/12.73)	RLNQVIQHRLV.TGKLMPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.45|      14|      15|     473|     486|       4
---------------------------------------------------------------------------
  473-  486 (27.88/18.46)	P.IMPEMQACLNGDR
  490-  504 (23.56/14.33)	PqIMTELRYWITHRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.20|      41|     564|     641|     740|       5
---------------------------------------------------------------------------
  684-  730 (65.34/102.72)	FLNlaqalTKYNVPH.CGLQVES.NAISLVLKIITLPQPTPPDDrKFPV
  892-  934 (62.86/11.97)	YLN.....TKHNLTQiVQLLHETyNPLSSIAKLPIIPHLGIPRP.QVPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.25|      26|      79|    1196|    1221|       6
---------------------------------------------------------------------------
 1196- 1220 (42.57/19.90)	.........................HEKFDLLC...RPSPH...PNKDITSTIDIS
 1221- 1251 (29.41/11.46)	P........................LERF.LGCvymRRQLYrnvQNEDTLTALNSN
 1253- 1299 (27.27/10.09)	PgvvlfkvdglqcqvilnqvhmqslHLKVNQL.....PPPH....TPDSKQPFQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.03|      32|     269|     553|     585|       7
---------------------------------------------------------------------------
  553-  585 (51.96/42.73)	HLKEK....SSMPNEMEYTfYLGLLVYQSNETEVLSE
  823-  858 (51.06/36.08)	HIKNKrlniTDMLSINSYN.YTNLLLGYGPKKEVLCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.50|      30|     393|      24|      54|       8
---------------------------------------------------------------------------
   24-   54 (48.30/35.33)	SRMNTISL...SVL..IDFTIQRTYHDLTVlAELLP
  410-  444 (42.20/25.81)	SRLSDLKLefqAFLkdVDFNLQGTPAILTV.PVLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.60|      35|     393|     631|     665|       9
---------------------------------------------------------------------------
  631-  665 (64.89/30.13)	HGPGTDVDDVPPHK..RKSN....SELTAP....PTKQAKTIYPA
 1006- 1050 (51.71/22.57)	RGRSQNEDDNPPSPigGEDNfggtSGLRFPaphtPPSSSNPHTPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09183 with Med14 domain of Kingdom Metazoa
Unable to open file!