<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09172

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSVNNKVTTIGTGSINPTTLLTNMSNAIEKNKQWQRELLMERIRSHSSQHKTFQELSKAMRMGMLEKRYALDAVEKSNLQKCLDSMQHCIKVTSRQGLVERLESLSRQLGLKFMDDTKVLFISTDMFFLEIVLDANGALSDVKVHHECKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAEPKVKTKAFDAMQAVESDLYNLFQMQSFSKDTQQVLKDSIVGIVLKRHGGHPMRLVYFVSPYDLISLESKSLQSLSLDLLHNKQVGFSVTVNLEASSANKLQILPTVSFAKESQSGLEVPVFAPLNQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCGSPTTSQSSAADINNSTVLEGQHKATLPMISNIMSLIIYTASEQQLKSSQKGLFVCLPDQTHCYFFTENKLLKSTLVQSIPFTEPSQVPKILDFLKRQALFYALLSSCVRPQSKMVNVDIDSTIILEVNAISYHQISVALQHPYEESMATVEFDLHNGNVQCIIYSLSNNYDLLSLKLTNVVQKCCSIPVTIRALLRYWDQERIKKFQRGIGAAAGSTGANTSSNGNNAVGNNTAYGNFNIAGVSNDPGGGGGGVGGGGGGCMNRGLGGSVKMEQALQQRSQLASTTTGYLKYKCGDIKQEDFHESPKSQTLAMVTDTTVANSMPAREVSSLGQQQQQTTHETLQQQANTTFTAEREIADKYKNIWKDKTPAIKNCVSITPIGTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSMNISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKCSTAAAMGSSSSSGLNPAALVRSSTSSTVVAAAAAAAAMAALKNKDKCTVSPSAVSSAAAAAAAAVVKSSMGVVTPTMQQLKSVTGLNHMAAAAAGFGGNTATVNSLDLNAAMRKGVPSAVSLMTSTAVTATINSTPAQRRATQQVHRHHQQRPIPLQPLGSSEGDNHTFNKNSSEYMVKSQSQEGLKLTINKTKAISTKKFGVNNDLTCKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLNKNKSLENSIEFLSNDNLRKSVKKSAVSTSSATSTHMSSLSAAPSQSALRIDYHADMIKILQYASPTMAASMEGFMKSFNTKFQIPKLSQRNATKTTTATTTAASIADTSKSGSLCITTSITKTCPSSTTGVSDVQAPPLPPTSNASSQQQSTMAATETPTIVNANQSLVSLHVLKSSPISSTSPNHMNSLTATKSALNFVDNSNVSNNSMCNESLLATLAGE
Length1416
PositionMiddle
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.331
Instability index50.45
Isoelectric point9.40
Molecular weight151080.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09172
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     200.86|      51|      57|     936|     986|       1
---------------------------------------------------------------------------
  768-  837 (52.74/23.74)	SNSSTGI......TITPINTGSS....SMniSGVSSKDKKSST..............TSSTCISNLPS.sttsakraldvqgelpkEKKRKKKRD
  874-  944 (48.22/20.97)	SSPKGSSggllasCVT....GSSlttrPS..PKHSP...VYSS..............PKHN.TASNSPkspfgthspkhsssgkpsMSTLKNATV
  945-  995 (67.51/32.77)	ASPKGDK......CSTAAAMGSS....SS..SGLNPAALVRSS..............TSSTVVAAAAA...............aaaMAALKN...
  996- 1046 (32.38/11.29)	....KDK......C.TVSPSAVS....SA..AAAAAAAVVKSSmgvvtptmqqlksvTGLNHMAAAAA...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.90|      36|     279|     219|     254|       2
---------------------------------------------------------------------------
  219-  254 (62.98/42.97)	QQVLKDSIVGIVLKRHGGHPMRLVYFVS.PYDLISLE
  485-  521 (59.92/40.53)	QHPYEESMATVEFDLHNGNVQCIIYSLSnNYDLLSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     310.77|      57|      57|    1282|    1338|       3
---------------------------------------------------------------------------
 1051- 1085 (35.72/13.47)	...................NTATV.NSLDLNAAMR.KGVPSA...VSLMTSTAVTATIN
 1089- 1113 (36.67/14.02)	AQRRATQQVHRHHQQRPI..................................PLQPLGS
 1134- 1184 (63.39/29.68)	SQ.EGLKLTINKTKAIS...TKKF.G...VNNDLTcKKLSASEKSWSPSQSKHTFQKSN
 1207- 1249 (47.24/20.22)	SNDNLRKSVKKSAVSTSSATSTHM.SSLS........AAPSQSALRIDYHAD.......
 1282- 1338 (93.07/47.07)	SQRNATKTTTATTTAASIADTSKS.GSLCITTSIT.KTCPSSTTGVSDVQAPPLPPTSN
 1341- 1376 (34.67/12.85)	SQQQSTMAATETPT...IVNANQSlVSL....HVL.KSSPISST...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.63|      30|     443|      81|     111|       4
---------------------------------------------------------------------------
   81-  111 (48.00/39.06)	QKCLdSMQHCIKVTSRQGLVERLESLSRQLG
  527-  556 (55.63/40.10)	QKCC.SIPVTIRALLRYWDQERIKKFQRGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.91|      41|     100|     172|     214|       5
---------------------------------------------------------------------------
  172-  214 (61.29/51.49)	TAQLEGfSSIYQLNAEPKVkTKAFDAMQAVESDLYN.LFQMQSF
  276-  317 (63.62/43.13)	TVNLEA.SSANKLQILPTV.SFAKESQSGLEVPVFApLNQMNSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      11|     279|     744|     755|      10
---------------------------------------------------------------------------
  723-  733 (22.38/11.98)	ITPI.GTQHDPI
  744-  755 (17.03/12.62)	IIPLtGQQHNSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09172 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFHESPKSQTLAMVTDTTVANSMPAREVSSLGQQQQQTTHETLQQQANTTFTAE
2) GTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSMNISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKCSTAAAMG
3) SSTTGVSDVQAPPLPPTSNASSQQQSTMAATETPTI
4) TATINSTPAQRRATQQVHRHHQQRPIPLQPLGSSEGDNHTFNKNSSEYMV
646
727
1320
1081
699
959
1355
1130










Molecular Recognition Features






MoRF SequenceStartStop




NANANA