<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09171

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDDWQDEQSRQKIVTKIKDMLRSNDKESIKSASLMENHIFSKSKTKEEYLGLLDQLYLYLKEMPIRKLTNEIPQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGVPGQQQGNVVGGPGSQQQMMNQMVGPGGLQMNIMGGPGGPQQSQMVGNAQQMTTGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQAGPGGNITVGAGPTGGAAQGMQGLPGNLQQNQGAGAVSQMHSGNVSGGPQVPSSAMGNNAGQVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKYKQLTKYIEPLKRMVAKFSNDGAQIEGQTKMRKLLEILSNPSQRVSLETLLKCEKVLEKMEIGNIVQQFGKSPNPLMEVITNTLQSPIANHTLYRTFRPTLELLLGTDISAPPPLKKSKTTNSNETEIPHLLQGELARLDTKFKVSLDTTVQNNTKSIKLICCLDDKKLPSVPPININIPEEYPLSSPDCILIEQDYSCTAFLKSVQSAFIARIAKLPKIYSLSHLLNTWEMSVRQACSPNTSKPICELTALFGM
Length656
PositionTail
OrganismGlossina morsitans morsitans (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.03
Grand average of hydropathy-0.576
Instability index52.78
Isoelectric point9.11
Molecular weight70972.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09171
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     470.08|      73|      73|     104|     176|       1
---------------------------------------------------------------------------
  104-  176 (151.09/49.78)	GGPGGPVTASNLLQSLNQQRPGQQQMQQM..QGMR.PQMPMGGV.PGQQQGNVVGGPGSQ.QQMMN...QMVGPG.GLQMNI
  178-  226 (81.10/22.96)	GGPGGP...........Q....QS...QM..VGNA.QQMTTGGSgPGVGQG..L.GPG.....QMN...QMVGPGsGGPMG.
  227-  296 (100.44/30.37)	SGAGGP....NQMQ..MQAAAGQMQGGPMnvHGMNvQQLP.GQM.PQQQMQQMSMQQHSQlNQMMNarmNQAGPG.G...NI
  300-  347 (72.93/19.83)	AGPTG..GAAQGMQGL....PGN..LQQN..QG.......AGAV.SQMHSGNVSGGPQVP.SSAMG...N............
  349-  396 (64.52/16.60)	..AGQVPTSSPQMSGL.MQNPNQRQMRQ......S.PSSNL.NT.PG.QVANSPFNPHEE.Q....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.77|      36|      45|     435|     475|       2
---------------------------------------------------------------------------
  407-  452 (50.84/31.40)	KYIEPLKRM.....VAKFSNDGAqiegqtkmrkLLEILSNPSQ.RVSLETLL
  453-  495 (47.92/40.64)	KCEKVLEKMeigniVQQFGKSPN.........pLMEVITNTLQsPIANHTLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.86|      13|      16|      65|      77|       3
---------------------------------------------------------------------------
   65-   77 (23.51/13.19)	PIRKLTNEIPQQN
   82-   94 (22.35/12.18)	PLNALQNLASQGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.69|      58|      86|     504|     565|       4
---------------------------------------------------------------------------
  504-  565 (86.71/73.99)	LLLGTDISAPPPLKKSKTT.NSNETEIPHLLQgeLARLDTKFKVSLDTTVQNNTKsiKLICCL
  592-  650 (94.98/67.33)	ILIEQDYSCTAFLKSVQSAfIARIAKLPKIYS..LSHLLNTWEMSVRQACSPNTS..KPICEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09171 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTNEIPQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGVPGQQQGNVVGGPGSQQQMMNQMVGPGGLQMNIMGGPGGPQQSQMVGNAQQMTTGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQAGPGGNITVGAGPTGGAAQGMQGLPGNLQQNQGAGAVSQMHSGNVSGGPQVPSSAMGNNAGQVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKY
69
402










Molecular Recognition Features






MoRF SequenceStartStop




NANANA