<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09163

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMNQRNSKSFDGHFDPLRQQNTPHPDNMRAVHHPPGRSVALSAEAKEFIPKNKMANDVGHRHQGPGQHHSHHPHMAHAYHPQQHHGQNFHHPPPQQIPSASGRQFPASAINHPYMHMQQQQQLAFMRHQQQQHMNHPIGLYTEMQLAQQMQRATVQDRLNSTRHQPIMQHHVPHAVHEAQGVQNNFEGGGGPVHENPPHEETGALDMLSHIIKQLTDQPGMYEEVQKHKKQKRHEDDKERKKRKKEKKRKKQRHSPEHPGGSIPPQTQIF
Length269
PositionHead
OrganismPhlebotomus papatasi (Sandfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Phlebotomus> Phlebotomus.
Aromaticity0.04
Grand average of hydropathy-1.406
Instability index53.56
Isoelectric point9.83
Molecular weight31119.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09163
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.09|      18|      21|     109|     129|       2
---------------------------------------------------------------------------
   86-  103 (33.58/12.56)	QN...FHHP...PPQQIPSASGRQ
  104-  127 (25.51/15.03)	FPasaINHPymhMQQQQQLAFMRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.72|      12|      80|     130|     142|       5
---------------------------------------------------------------------------
  130-  142 (21.26/11.43)	QQHMNHPiGLYTE
  212-  223 (20.46/ 6.88)	KQLTDQP.GMYEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.78|      18|      24|     154|     177|       6
---------------------------------------------------------------------------
  154-  173 (25.48/19.25)	VQDRLNSTrHQPImQHHVPH
  181-  198 (35.30/10.30)	VQNNFEGG.GGPV.HENPPH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09163 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNQRNSKSFDGHFDPLRQQNTPHPDNMRAVHHPPGRSVALSAEAKEFIPKNKMANDVGHRHQGPGQHHSHHPHMAHAYHPQQHHGQNFHHPPPQQIPSASGRQFPASAINHPYMHMQQQQQLAFMRHQQQQHMNHPIGLYTEMQLAQQMQRATVQDRLNSTRHQPIMQHHVPHAVHEAQGVQNNFEGGGGPVHENPPHEETGALDMLSHIIKQLTDQPGMYEEVQKHKKQKRHEDDKERKKRKKEKKRKKQRHSPEHPGGSIPPQTQIF
1
269










Molecular Recognition Features






MoRF SequenceStartStop




1) HEDDKERKKRKKEKKRKKQRHSPEHPG
2) LSAEAKEFI
3) SIPPQTQIF
233
40
261
259
48
269