<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09152

Description Uncharacterized protein
SequenceMPPQPLPLEGGGPVNFMPSSGQEPRGGSISLAILIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLFIRLLALVKWANSASKVDKSAQIMSFLDKQSMLFVETADMLARMARETLVHARLPTFHIPAAVEILTTGTYGRLPACIREKIVPPDPITTNEKRQTLLRLNQVIQHRLVTGSLLPQMRKFKIDGGRVTFRIEHEFEVSLTVMGDGPNVPWRLLDIDILVEDKETGDGKALVHVLQVNYIHQLIQARLVDNQNALAEVYNCLHFFCQSLQLEVLYTQTLRLIRDRLHEMIYVDEYIPGSKLTVSYWRELTSKDPKSELGYRLTVQTDPNDSARPLAVFHIPSIGNKRLLVHTVYVRSLARLNEIKVEFQTFLKDVEYHLQGTPAILTVPILSPCLRAEQVHITVDTHTGIFHCHVPKHLECPIVPDLQAALNNDYTKLPYLISELRYWITQRRCEKTLQHLPATPHEHLPLIHSSDHPIVKIGRHKVFVKLHRHPNVILVLEMREKAKIPSEMEYNFFLVYVKPTGIEGVEAGDENSDTDVPKMYLKVLNLIEFDTFVTTHGPGTFLDESVNNKRKASHMDSGPAAKQQKTIYPAYFIPELAHVVARAFHIELSTRGVERVLLSTCNGPGLGRRLLSVAVRAQVNRHTTRLWIVELVFYGTPLPSAHHKEQGLRRAVYLQYDLMPVDQFGKTIDSLLNDWSKIVYLYALVHDFSEKYKNDKYNLQNIVTVKSYTYTSLLLGYGPNKEVLVNIFWCTESKEFKMIFSGGHSATNSHSMMREQLQSHLNRNYNLTQIIHILHETYQPLSSIAKLPTIPQLGIVRPQNPVLTFCLFPQSPTLLRVEYQSLYCLEIRLRGGGLISIRDGAYSRFDRCNVLQELIPTPGLKAFLSKYVDESTVYRRRSQSEDDNPPSPIAMEEPQGGPTSVGGSSPFLGLRGPQSPRDAGLRFASPITPPSGSNPHTPASPHALASAQGHPNFSMTSPPAPHMPHPSPSGIMPSSPLNTQPSPMAHSPGPNSLSYMQQGHTTDGSPFPTLSPGASNWPGSPSMPRPSPRSGQSPDHKTQQQPSTTHLSRVLPARSWAGAVPILLTHEALDTLCRPCSHPQKEIPGPDLSPLERFLGCVYMKRHLLRFIQNEMTPLPSNEPGSVFFKADGLQCQVFLNQAHMQSLHMKVSQIQNVGAPEMHQWSQEELQIIEQFFELRVAAPPYRPNGLCAFARMINVNMSRVLKDFIQIMRLELMPELVQGLKWNVQFCLRVPPSAMPIVPTGMPAVLPFRGKILFFLQITRIPYVQGMDWKDCLSLVLPMVYDTGTNSTQLAERREQVQSVAMGAVSHQLKRFAEYAALQPNECSLFPAVRDLLANLMLPTESQIPPQIQNQIAPSPVGQVGTSPSQMMHSPMQSMAQGGPPTGAYNMVPPGGPN
Length1435
PositionTail
OrganismPhlebotomus papatasi (Sandfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Phlebotomus> Phlebotomus.
Aromaticity0.08
Grand average of hydropathy-0.235
Instability index55.12
Isoelectric point8.73
Molecular weight161221.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09152
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     146.10|      20|      20|     969|     988|       1
---------------------------------------------------------------------------
  925-  952 (23.75/ 6.76)	PSPI....AMEEPQ.......G...........gP..TsvgGS....SPflglRGP
  953-  977 (25.63/ 7.88)	QSPRdaglRFASPI.......T...........pP..S...GS....NP....HTP
  978- 1000 (25.71/ 7.92)	ASPH....ALASAQ.......G...........hPnfS...MT....SP....PAP
 1018- 1048 (24.61/ 7.27)	TQPS....PMAHSP.......GpnslsymqqghtT..D...GS.....P....FPT
 1049- 1070 (23.42/ 6.56)	LSPG....A.SNWP.......G......spsmprP..S..........P....RSG
 1403- 1434 (22.98/ 6.30)	TSPS....QMMHSPmqsmaqgG...........pP..T...GAynmvPP....GGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.03|      15|      50|    1245|    1263|       3
---------------------------------------------------------------------------
 1245- 1263 (21.91/21.93)	FIQIMRlelMPeLVQGLKW
 1296- 1310 (32.13/17.61)	FLQITR...IP.YVQGMDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.41|      27|     225|     848|     916|       4
---------------------------------------------------------------------------
  887-  916 (39.01/73.24)	CNVLQELIPTPGLKAfLSKYVdeSTVYRRR
 1115- 1141 (53.40/13.84)	CSHPQKEIPGPDLSP.LERFL..GCVYMKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.69|      79|     270|     288|     455|       5
---------------------------------------------------------------------------
  358-  455 (118.24/182.61)	GNKRLLVHTVYVRSLAR.LNEIKVEFQ.....TFLKDVEYHLQGTPaILTVPILSPCLRaEQVHITVDthtgifhchvpkhlecpIVPDLQ.....AALNNDYTKLPYL
  631-  720 (124.45/48.88)	GVERVLLSTCNGPGLGRrLLSVAVRAQvnrhtTRLWIVELVFYGTP.LPSAHHKEQGLR.RAVYLQYD.................LMPVDQfgktiDSLLNDWSKIVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.56|      42|     269|     288|     354|       7
---------------------------------------------------------------------------
  226-  275 (57.07/35.44)	RLLDIdILVEDKETGDGkalvhvLQVNYIHQL........IQARLV......DNQNALAeVYNC
  299-  354 (62.49/51.30)	RLHEM.IYVDEYIPGSK......LTVSYWRELtskdpkseLGYRLTvqtdpnDSARPLA.VFHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.98|      20|      67|     733|     752|      10
---------------------------------------------------------------------------
  733-  752 (33.84/25.71)	NDKYNLQNIVTVKSYTYTSL
  801-  820 (36.15/28.05)	NRNYNLTQIIHILHETYQPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09152 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPPQIQNQIAPSPVGQVGTSPSQMMHSPMQSMAQGGPPTGAYNMVPPGGPN
2) VYRRRSQSEDDNPPSPIAMEEPQGGPTSVGGSSPFLGLRGPQSPRDAGLRFASPITPPSGSNPHTPASPHALASAQGHPNFSMTSPPAPHMPHPSPSGIMPSSPLNTQPSPMAHSPGPNSLSYMQQGHTTDGSPFPTLSPGASNWPGSPSMPRPSPRSGQSPDHKTQQQPSTTHLSRVL
1385
912
1435
1090










Molecular Recognition Features






MoRF SequenceStartStop




NANANA