<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09147

Description Mediator of RNA polymerase II transcription subunit 1
SequenceVCVIFSKIFPIDFCVNRWALFLAKCVQRNSRTPCSTQQSTMSSKINGNPPLTMNSIGEKNKKWQLELLMERLRIVLIGWILQEKRYALDAVEKANLQKCLDSMQHCIKVTTRQGLVERLESLTRQLGLKFMEDTSGLFISSDMFYLEIVLDAGGAVQDVKVHHECKIEQQSCSELVNCLVNGDFADFTTQLEGLASIYQLNAEPKIKSKAFVALQALETDLYNLYKLQNFYKDPQALLLQSQVGIVQKRRGGHPMKLTYFVSPYELLDTESKTILPLTVEVIHGRNVGTSVTVNLEASAANKLQIQSILTVSPDGQPVYAPLATHNSTMLPASFVLTLNRKMPVTLSLVQQMTSVTEISFGPDPTASEPLLGLIAAQSADGELSGSSKGMFVTLPDQNHCYFLTEGESFRGIVIGSVPFTEPAHVPKLLKILRQQVLFNTLISSCIRANSRQDFDSTTVFEVSALSCQHLTVSLEHPFDEAMATVEFDLTDVMDIQCKVFAPGRSYENLGTILSRVVQKSLSIPVTMRALIKAWEQENSLQATRTFDAGNFNLALGPGDPGGRNSTTTDFTKTTDIKPSSSAARSLFSDPEPGPGEAEEAAGDEEGIQDEASEGFGEADLDAFGEEVAAEALGEGAGGAFQVVTASDGSGKSVKKRRVEEDFWKSPKSNVLGNVSDSGSNSDSNSLGAESADGGVTASSWHQPSDVEATSFNISPALSDLGDGSKKVKKRSRDEANDKNVMPPFVSITPISTASSTNFSSVLAGIGLDRRPGIEIIPLGATQNLSSSITITPINTSSSSSPKEKKSSSSSKKSSSDDRKGEKKKKRKREDSPMGPPDALNKPVSVSIKGSDGAPLSPSGLMRKFSSSSSPKQSSPGGHHQSPKHGGLQSPKQYSSASPKHSSGTGSGKPSMSALKSATNSPSGKSSEKKSSSSSSGGGSSGSREKEKSEKKSSSSRSDSPKMKASSVKLKQIDLSSAFQLTGVDVDLQDLNKSSPPSQSKNRKGSLSAVIDKLKLAQNQTDEPKAGSGNGKEKSPPKSDGIPPTSSSYMVKPSLDGMKITINKTRNKESSPKTTESTGKLNLGSGSGGGSGSNSPKTHTGLKPGVNSGPASKKSQQNSSNLSGTSKSSSSSDSNRSSFQKSNSSGSLSGSSSKVSGNGSGGFTKTSSGSDLSKVSSTVNHGSSEKQRTEKSKAPQKNTFESVFLQANREADAMKKLGFGGSTMEGFMKALDKKFQIPKLSARSASTDEVKKESRPVSSSSAPTTPIPLMMASPTGSNSGSASFQGVTGGVTKMLAEYLTKEVPSKYPFSGSASAGSGSGTSPKYGGVFSSEISLGKSLSQDSLQFAAGGQNRESGGVRSNPSTPTSLVASPFPSPVAISRSSADSPAPRAAESDSSKSSLTKDSTNSPLAAMRPPSAPPTPIQATSGDSGALDFSTRAPPPPTKSSSTVSTFPPSPSVSLHIVKSPVPSPLVIPSPHSGSPCITDDELMDEALVGISGK
Length1499
PositionMiddle
OrganismPhlebotomus papatasi (Sandfly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Phlebotomus> Phlebotomus.
Aromaticity0.05
Grand average of hydropathy-0.477
Instability index56.57
Isoelectric point8.99
Molecular weight157906.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09147
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     274.82|      38|      38|    1107|    1144|       2
---------------------------------------------------------------------------
  799-  829 (33.16/ 7.00)	SS....PKEKK....SS...SSSKKSSS..........DD.RKGEKKKKRKRE
  852-  884 (40.06/10.19)	GA....PLSP.....SGLMRKFSSSSSP..........KQ.SSPGGHHQSPKH
 1069- 1103 (38.80/ 9.60)	SS....P...KTTESTGKLNLGSGSGGG..........SG.SNSPKTHTGLKP
 1107- 1144 (60.83/19.79)	SG....PASKKSQQNSSNLSGTSKSSSS..........SD.SNRSSFQKSNSS
 1148- 1183 (38.98/ 9.69)	SG....SSSKVSGNGS...GGFTKTSSG..........SDlSKVSSTVNHGSS
 1260- 1287 (31.71/ 6.33)	SA....PTTPIPLMMASP.TG.................SN.SGSASFQ..GVT
 1355- 1406 (31.27/ 6.12)	GGvrsnPSTPTSLVASPFPSPVAISRSSadspapraaeSD.SSKSSLTKDSTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.00|      38|      43|     712|     754|       3
---------------------------------------------------------------------------
  674-  748 (30.46/21.00)	.VSDSGsnsdsnslgaesadggvtasswhqpsdveatsfNISPALSDL..................G.D...GSKK.VKKRSRDEANDKNvmppfVSIT
  749-  791 (41.08/17.24)	PISTAS...............................stNFSSVLAGI..................GlDrrpGIEI.IPLGATQNLSSS......ITIT
  995- 1042 (39.85/16.50)	PPSQSK.................................NRKGSLSAVidklklaqnqtdepkagsG.N...GKEK.SP.......PKSD......GIP
 1043- 1068 (29.61/ 9.04)	PTSSSY.................................MVKPSL.......................D...GMKItINKTRNKE..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.42|      27|      50|     885|     913|       4
---------------------------------------------------------------------------
  885-  911 (51.07/17.05)	GGLQSPKQYSSASPKHSSGTGSGKPSM
  936-  962 (46.36/11.91)	GGGSSGSREKEKSEKKSSSSRSDSPKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.03|      41|      43|     558|     599|       6
---------------------------------------------------------------------------
  558-  599 (67.75/40.00)	GDPGG.RNSTTTDFTKTT.DIK...PSSSAARSLFSDpEPGPGEA....EE
  602-  645 (43.96/20.03)	GDEEGiQDEASEGFGEADlDAF...GEEVAAEAL....GEGAGGAfqvvTA
 1217- 1247 (36.33/14.83)	GFGG....STMEGFMKAL.DKKfqiPKLS.ARSASTD..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.51|      24|      38|     646|     670|       7
---------------------------------------------------------------------------
  646-  670 (37.57/25.02)	SDGSGKSVKKRRVEEDFWKSPkSNV
  683-  706 (41.95/23.80)	SNSLGAESADGGVTASSWHQP.SDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.15|      15|      19|    1417|    1435|       8
---------------------------------------------------------------------------
 1417- 1434 (23.16/12.87)	APPTPIQATSGDSgalDF
 1438- 1452 (27.99/ 9.64)	APPPPTKSSSTVS...TF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09147 with Med1 domain of Kingdom Metazoa
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