<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09140

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMLDLLFSVHKKVPTALPIDTSNSRNFVTVSSCNIIAFTSNFDLTTGAYGYHCYICDINAPWNVYKVTSNKYPISILAWDVLGKYLLIGDTFGSICIWMQKDNFLSEWCHVYTATFPGECIIKAVFFHNGRKISFNADKKEASSYSDKFQKVKFFPSVRQFGGVPTEGFLVITASGLIGAVAIPPEQPTAPSPAPPPANPPAQPAANQPQAAPLPPPQPPVIVIPHILATVTESLGQTRSFYTTADVCYGKNGHFLIAASNNDYQNRTLIVQCFRVIVKKVEEKLTITSHSLPSFFLNEGIGRDLPDLDLLKLKWTFQEDTDTLIVAMNSSIGGFIEVWGLVEKSTPIHKLFQANKSEVFKAFVWTPQSHFRYTSKILNICTSKLQLGSSGYISVVMADNSVFCLHRDTLSKAASGSLSIAHRIDDGAKQTKLNSTPRDIDVSWMGHLLVCLDNLGQLFVFKSNNMPEQLGMPSTIQHTVSLLEYCIVAGYDYLDILLAIRSSTIDNIVERLSENFNRQVNPIQQFYYVNFLTMKTNLYRLSPSGQSKSQDLACLLMLHSILIAFKSLLRPSDLTCHDKGPAEYLAMGLSESNTDVDKVLLNLEAKDFTVEPSTLQSLQQLIQWVSDLALNILARLPETRSSGGNMKNTGYEISHDVVALNSIRELLVMIRIWGLLKEQCLPIFARADSLDILSTVFRLLTRLAFNPNEPDDMLLDECCLLPSQVMIPQLPFVTMRVSVASPLLANLSLPLYFEYNVEPECLKFSVDNNPMENGGVSNDSVVDSVRHLQLGKMPPMLRKCCRCGAATAMNSVARTAAMKAWEQRWSSGCRCGGFWRLQSYV
Length840
PositionTail
OrganismLutzomyia longipalpis (Sand fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Lutzomyia> Lutzomyia.
Aromaticity0.09
Grand average of hydropathy0.026
Instability index43.75
Isoelectric point6.78
Molecular weight93437.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09140
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     430.90|     110|     331|     238|     347|       1
---------------------------------------------------------------------------
  238-  347 (183.21/115.31)	RSFYTTADVCYGKNGHFLIAASNNDYQNRT..LIVQCFRVIVKKVEEKLTITS...HSL..PSFFLNEGIGRDLPDLD..LLKLK.WTFQEDTDTL.........................................IVAMNS..SIGGFIEVWG..LV.EKSTPI
  431-  522 (125.22/76.49)	KLNSTPRDIDVSWMGHLLVCLDN..........LGQLFVFKSNNMPEQLGMPStiqHTV..SLLEYCIVAGYDYLDI...LLAIR........................................................SS..TIDNIVERLSenFN.RQVNPI
  523-  682 (122.47/74.65)	QQFYYVNFLTMKTNLYRLSPSGQSKSQDLAclLMLHSILIAFKSLLRPSDLTC...HD.kgPAEYLAMGLSESNTDVDkvLLNLEaKDFTVEPSTLqslqqliqwvsdlalnilarlpetrssggnmkntgyeishdVVALNSirELLVMIRIWG..LLkEQCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.46|      15|      15|     186|     200|       2
---------------------------------------------------------------------------
  172-  187 (22.59/10.06)	TASGLIGAVAIPPeQP
  188-  203 (27.89/14.14)	TAPSPAPPPANPPaQP
  204-  218 (29.98/15.75)	AANQPQAAPLPPP.QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.66|      17|      21|      32|      48|       4
---------------------------------------------------------------------------
   32-   48 (30.64/18.34)	CNIIAFTSNFDLTTGAY
   55-   71 (33.02/20.29)	CDINAPWNVYKVTSNKY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09140 with Med16 domain of Kingdom Metazoa
Unable to open file!