<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09136

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMTDEQYIVPRRIQKRYEQRFRDAWLENPLLKDWLRDCYTPEGIREARCIYCNIRLCPRFIDLSKHAMTRKHMKNTPHEGSLIVHSSDVEESEDAEGQGEVEEYETEETKNENIMYEVILDHPNKEDTVEQHTQEEATIEQLHLETSGNSSTSVEPPLKILKMGFKSNNGDEGTSQVPKDVSPPTTVLRKVKATSTEPNILLERKKLVLQIKNEELRAYKMQLEAFKMERELGFESTRRGQKSRKKMSAPNVPISTIEGLSHALKCNIIPNQEYYLQGSILDSQVEHLLHRLKGLCDNVDSGPEPFHDHEICFSLRGQNQQLQLRVRKAQDVDAPFQLRYIGQPEVGDRSRPTLIRSSIDISCTASVLEFLTELGCRIDFEYANRGYMFRKGRMKITVSKIFKVGGLQPTDPISQSYLVELSILAPSGQDVIGEEMRILAEQLKPLVQLEKIDYKRTL
Length457
PositionHead
OrganismLutzomyia longipalpis (Sand fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Lutzomyia> Lutzomyia.
Aromaticity0.06
Grand average of hydropathy-0.647
Instability index54.23
Isoelectric point5.94
Molecular weight52574.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364150

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09136
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.56|      15|      25|     147|     161|       1
---------------------------------------------------------------------------
  147-  161 (26.84/16.53)	GNSSTS.....VEPPLKILK
  169-  188 (21.71/12.14)	GDEGTSqvpkdVSPPTTVLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.26|      34|     144|     231|     280|       2
---------------------------------------------------------------------------
  231-  264 (59.30/30.41)	LGFESTRRGQKSRK.KMSAPNVPISTIEGLSHALK
  282-  292 ( 6.35/27.39)	........................SQVEHLLHRLK
  377-  406 (40.61/16.07)	IDFEYANRGYMFRKgRMKITVSKIFKVGGL.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.19|      17|      27|     100|     116|       3
---------------------------------------------------------------------------
  100-  116 (28.95/14.65)	VEEYETEETKNENIMYE
  128-  144 (28.23/14.14)	VEQHTQEEATIEQLHLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.98|      27|      28|     304|     331|       5
---------------------------------------------------------------------------
  304-  331 (43.84/31.33)	PFHDHEICFSLRGQNQQLQLrVRKAQDV
  334-  360 (47.15/29.08)	PFQLRYIGQPEVGDRSRPTL.IRSSIDI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09136 with Med18 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ENIMYEVILDHPNKEDTVEQHTQEEATIEQLHLETSGNSSTSVEPPLKILKMGFKSNNGDEGTSQVPKDVSPPTTVLRKVKAT
2) MTRKHMKNTPHEGSLIVHSSDVEESEDAEGQGEVEEYETEE
111
67
193
107










Molecular Recognition Features






MoRF SequenceStartStop




NANANA