<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09131

Description Uncharacterized protein
SequenceMSTAAASSADHCHPHHHDHHVHFDESAIKENLEADNSIVYQKSGEDGVLVHLGFLQINHRYLLELQLPSTVSPAFLFGERIALSRDERCLPNVNCKYIEFTGKVGGHYDLKVEFLAHKEKLLREELHLVNVQNFEEKLKLVLSARVLGRGKGTPMLRNGIHCVGVEQDEESEASDWQGFSKGEGSKETMSVYNLIYDMKKKRPLKRPRLGPPDIYPQEAKQKEDELTSSNVKQGFTLLPHMEEFGTARNYNVTANKVGSYFNAILARKEELMTLPDSGRKKQQINPKDNFWPVTARTKATLDTWFKDLAGTKPLVSLAKKAPSFNKKEEIFAILSENQVSMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTMIKFMRELIPKLHEHYYQGVLPEKLQSSSASSSTPTSSASSTSITNTVPTPLTSPASSMHSPGNLGSTPSSTLLAPPSPQDEHKLALKQWTYCMQLSKYMYEEGLLDKHEFLNWILDLLDKVRSQPTDDGLLKLFLPLALQYMSDFVQSERLSRRLAYLVCKKMGHMINSAVENRHLMSQETAAAATAGNVKTEPAEAQNTDASKNPENADAKENPNKTGAKSAPVNGVQSTNPYTFFSDYMNCAHHRDLILQWSAIIQVITIECPTALVWCGIGENRASSIFIGSPLDHLPISPSSLPMPPRFTQANEEIRKQLRVVEESIKIRSKHAEARWCTDKWQSRWGEHRAMAVAWLLDKRQTEVTSSNENEATNGNSDDKDSISSGAGINGSPVFQKILMNFLDNDAPVLEENGSPQNRSQFTNLVHLFSELIRHDVFSHDGYMCTLIARGDLTTKGISATQPHTNVIPPGPISNPTKTSPGMHPGLDEDVFAGIEFKSKIEEFDDSNVDDDLDKLLQHIKSDQQNSMDAPDSPKDPDNSTQGASHIGIGTDSTVSRHFLYTKHFPLSQDGDMASQHDCNQRYILLFGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGILKELPEVESQLISKNSILVRNYTTSLSLYVVGVLRRYHCCLLLSPEQTSAVFEGLCKVVKHVTNPGDCSSAERCILAYLFDLYSSCSLLKTKPQPTEPFHNAYPKIKQALYSAVQIQASTHPYNPQFMIEILTQPKRGGKIEAGWGRPLNDSAANRYSFVCNAILAVVRENDNDRLNDIAATCAELTACCNALSAEWLGALVALCGSSNDTFYPDIVCQVDVQNLSIHNALAVFTCILVARHCFSLENFVASVALPALVAICNGTGRDMTPEAEAGARLTCHLLLRLFKTIEIPQPGLYSVSTSPNPIISGPACNIKLSCDRHLLAAAHKNIAVGPVLAVLKGILVVGDAMAHKASSVHSSGKRSGLNTPVHPGSTPKSMGSAGDLSHILGTSEFGLLGNCDEPMLDSSQQNHSVHSENASSLYDFAQHVLRQICSQEWVLERCLQNAEELCLPGMLIDPMLTPKQAQRLLHMICYAENESNMKAEMDQKSIIVRILENLEQWSLRISWLDLQLMFKQTNSNSAELTNWLDTEKPSIWLVAPLVSKLPSQVQGRILRVAGQVLESTNIFGAKGRDSGNGGNNGGGSCSKRKATPQLSHQPFLGLVLTCLKGQDEQKEGLLTSLHTQLSQFLQSNKEMERIGGIEDPQGRESMLDALQLRFSLVGGMFDSIQKNAASTTDWAILLAQLISQGVIDLTNNSELFTTVVDMLATLIHSTLVSDSQSERDDTKKSYTNLMKKLRKELGDKNNASVKFVRQLLPLSKQTCEVIACDSASSLTDTKGNKISGFDSIDKKYGLRIADKQRVSVWDLLEGHKNPAPLSWAWFGAVKMERKPLAYEDSHRLLKYHTHSLTKPSSYFHEPLPLPPEDLEPLPEKPVSFGDASKQDTLLKMLSLQKEDMKADTPSSVDQSPSAMIGTNGRVKPKGRRPRKPKPGPANIPINQPQQPQPPPQQQQQQQQQQPMQTQMPN
Length1965
PositionKinase
OrganismLutzomyia longipalpis (Sand fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Lutzomyia> Lutzomyia.
Aromaticity0.06
Grand average of hydropathy-0.410
Instability index49.16
Isoelectric point6.67
Molecular weight217780.27
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09131
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.88|      52|      54|    1355|    1408|       1
---------------------------------------------------------------------------
 1355- 1408 (86.59/67.50)	SVHSSGKRSGLNTPVHpgSTPKSMGSAGDLSHIL.GTSEFGLLGNCDEPMLDSSQ
 1412- 1464 (89.28/61.96)	SVHSENASSLYDFAQH..VLRQICSQEWVLERCLqNAEELCLPGMLIDPMLTPKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.56|      46|     449|     820|     868|       3
---------------------------------------------------------------------------
  820-  865 (81.50/50.89)	CTL......IARGDLTT..KGISATQPHTNVIPPGPISNPTKTSPGMHPGLDED
  874-  927 (68.06/34.53)	SKIeefddsNVDDDLDKllQHIKSDQQNSMDAPDSPKDPDNSTQGASHIGIGTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.53|      58|     449|     594|     684|       4
---------------------------------------------------------------------------
   12-   75 (86.38/35.50)	ChPHHHDHHVHFdeSAIKE..NLEADNSIVYQKSGED.GVLVHLGfLQINHRYLLELQLPstVSPAF
  622-  682 (100.14/ 8.45)	C.AHHRDLILQW..SAIIQviTIECPTALVWCGIGENrASSIFIG.SPLDHLPISPSSLP..MPPRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     316.71|      99|     500|    1083|    1184|       5
---------------------------------------------------------------------------
 1083- 1184 (160.92/112.81)	SCSLLKTKPQPT.EPFHN.AYPKIKQALYSAVQIQASTHPYNPQFMiEILTQPKRGGKIEAGWGR.PLNDSAANRYSFVcNAILAVVRENDNDrLNDIAATCAEL
 1584- 1685 (155.79/96.08)	SCSKRKATPQLShQPFLGlVLTCLKGQDEQKEGLLTSLHTQLSQFL.QSNKEMERIGGIEDPQGReSMLDALQLRFSLV.GGMFDSIQKNAAS.TTDWAILLAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.38|      35|     858|      76|     111|       6
---------------------------------------------------------------------------
   76-  111 (60.30/47.97)	LFGERIALSRDERCLPNVNC..KYIEFTGkVGGHYDLK
  935-  971 (60.08/42.68)	LYTKHFPLSQDGDMASQHDCnqRYILLFG.VGKERDEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.27|      18|      55|    1196|    1213|       9
---------------------------------------------------------------------------
 1196- 1213 (33.36/21.71)	LGALVALCGSSNDTFYPD
 1253- 1270 (33.90/22.19)	LPALVAICNGTGRDMTPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.51|      37|     772|     722|     758|      10
---------------------------------------------------------------------------
  722-  758 (63.04/43.71)	EHRAMAVAWLLDKRQTEVTSSNENEATNGNSDDKDSI
 1499- 1535 (66.47/46.55)	EQWSLRISWLDLQLMFKQTNSNSAELTNWLDTEKPSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.56|      28|    1356|     358|     388|      12
---------------------------------------------------------------------------
  358-  388 (45.85/42.99)	VSEAKIKKrqmPDPATEWTGTM..............IKFMRELIP
 1716- 1757 (38.71/26.44)	VSDSQSER...DDTKKSYTNLMkklrkelgdknnasVKFVRQLLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09131 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGNVKTEPAEAQNTDASKNPENADAKENPNKTGAKSAPV
2) DLDKLLQHIKSDQQNSMDAPDSPKDPDNSTQGASHIG
3) ISATQPHTNVIPPGPISNPTKTSPGMHPGLDE
4) SSSASSSTPTSSASSTSITNTVPTPLTSPASSMHSPGNLGSTPSSTLLAPPSP
5) SSYFHEPLPLPPEDLEPLPEKPVSFGDASKQDTLLKMLSLQKEDMKADTPSSVDQSPSAMIGTNGRVKPKGRRPRKPKPGPANIPINQPQQPQPPPQQQQQQQQQQPMQTQMPN
566
887
833
405
1852
604
923
864
457
1965










Molecular Recognition Features






MoRF SequenceStartStop




1) KGRRPRKPKP
1921
1930