<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09130

Description Uncharacterized protein
SequenceMPPHPLEGGAPVNFMPSSGQEPRGGSISLAILIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLFIRLLALVKWANSASKVDKSAQIMSFLDKQSMLFVETADMLARMARETLVHARLPTFHIPAAVEILTTGTYGRLPACIREKIVPPDPITLSEKRQTLQRLNQVIQHRLVTGSLMSQMRKFKIDAGRVTFRIEHEFEVSLTVMGDGQNVPWRLLDIDILVEDKETGDGKPLVHVLQVNYIHQLIQARLVDNQNALAEVYNCLHFFCQSLQLEVLYTQTLRLIRDRLHEMIYVDEYIPGSKLTVSYWRELTNKDPKSELGYRLTVQTDPNDTARPLSVFHIPSIGNKESSEVADRAVRSDLLSMERLLVHTVYVRSLARLNEIKVEFQTFLKDVDCHLQGTPAILTVPILSPCLRAEQVHITVDTHTGIFHCHVPKHLECPIIPDLQAALNNDYTKLPHLISELRYWITQRRCEKTLQHLPATPHEFLPLIHDAEHPITKIGRHKVFVKLHRHPNVILVLEMREKVSTVSEMEYNFFLVYVKPTRTENVDAADENNEPDVPKMFLKVLNFIEFDTFVTTHSPGTYLDESVGNKRKSSQQDGGPAAKQQKTIYPAYFIPELAHVVAMCDEKLPFVTFAQELSKRKIPHGGLQVEANATSLVLKLLTLPKPIPPQVDNKTISTPIVDNTVWNALLKRLLSVAVRAQVNRHTTRLWTVELVFYSTPLLSTHHKEQGLRRAVYLQYDLMPTDKFGKTIDSLLNDWSKIVYLYALVHNFAEEYKNDKYNLQNIVMIKSYTYASLLLGYGPNKEVLVNIFWCTESKQFKMIFSGGHSAINSHSIMREQLQSHLNRNYSLTQIVHILHETYQPLTSIAKLPTIPQLGIVVNLPRPQNPVLTFCIFPQSSTLLRVEYQSLYCLEIRLRGGGLISIRDGAYSRFDRCNVLQELIPTQGLKAFLSKYVDESTVYRRRSQSEDDNPPSPIAMEEMQGGPTSVGGSSPFLGLRGPQSPRDAGLRFAPPITPPSSSNPHTPASPHTMASAQGHPNFSMTSPPAPHMPHPSPSGIMPSSPLNTQPSPMAHSPGPNSLSYMQQGHTTDGSPFPNLSPGASNWPGSPSMPRPSPRSGQSPDHKQQQPTTPHLSRVLPARSWAGAVPTLLSHEAFDTLCRPCPHPQKDIPGPDLSPLERFLGCVYMKRHLQRFIQNEMTQLPSNEPGVVFFKVDGLQCQVFLNHTHMQSLHMKVSQLQNVGVPDVHQWSQEDLQIIEQFFELRVAAPPYRPNSMCAFIRMINVNIPRVLKDFIQIMRLELMPELIQGLKWNVQFCLRVPPSAMPIVPTGMPAVLPFRGKILFFLQITRIPYMQGMDWKDCLSLVLPMVYDTGTNTTQLAERREQVQSVAMSAVSHQLKRFAEYAALQPNECSLFPAVRDLLANLILPTEPQLPPQIQNQIVPSPVGPVGTSPSQMMHSPMQSMSQGGPTTGTYSMVPPGGPN
Length1496
PositionTail
OrganismLutzomyia longipalpis (Sand fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Psychodoidea> Psychodidae> Lutzomyia> Lutzomyia.
Aromaticity0.07
Grand average of hydropathy-0.240
Instability index54.37
Isoelectric point8.56
Molecular weight168719.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09130
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     330.38|      61|      78|    1070|    1130|       1
---------------------------------------------------------------------------
  972- 1026 (36.07/12.90)	.................STV.....YRRRSQSEDD..NP.P..S...PIAmEEMQGG.PtS.........VGGSSPflglRgpqsprdAGLRFAP
 1027- 1060 (47.94/19.88)	PITPPSSSNPHTPaSPHTMA......SAQGH.......P..NFS...MT.........................SP....P..............
 1077- 1134 (120.43/62.50)	PLNTQPSPMAHSP.GPNSLS.....YMQQGHTTDG..SPFPNLS...PGA.SNWPGS.P.S.........MPRPSP....R.......SG...QS
 1135- 1186 (52.25/22.42)	PDHKQ.....QQP..................TT.......PHLSrvlP.A.RSWAGAvP.TllsheafdtLCRPCP....H......pQKDIPGP
 1187- 1221 (26.82/ 7.46)	DL....SPLERFL.GCVYMKrhlqrFIQNEMT......QLPSNE...PG..............................................
 1461- 1496 (46.87/19.25)	PVGTSPSQMMHSP.....MQ.....SMSQGGPTTGtySMVP......PGG.PN..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.64|      57|     542|     826|     902|       5
---------------------------------------------------------------------------
  791-  824 (43.37/12.36)	.................................NDKYNLQ..NIVMIKSYTYASLL....L.GYGPNKEVLVNI
  826-  896 (86.14/79.92)	WCteskqfkmIFSgghsaiNSHSIMREQLQSHLNRNYSLT..QIVHILHETYQPLTSIAKL.PTIPQLGIVVNL
  906-  961 (73.13/36.96)	FC........IFP......QSSTLLRVEYQSLYCLEIRLRggGLISIRDGAYSRFDRCNVLqELIPTQGL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.63|      14|      30|     413|     427|       6
---------------------------------------------------------------------------
  413-  427 (22.27/15.10)	PAILTVPILsPCLRA
  446-  459 (28.36/15.14)	PKHLECPII.PDLQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.24|      19|      44|    1320|    1343|       7
---------------------------------------------------------------------------
 1320- 1343 (29.03/26.20)	QGLKWnvQFCLRVppsAMPIV.PTG
 1367- 1386 (34.21/16.00)	QGMDW..KDCLSL...VLPMVyDTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.73|      11|      34|     517|     527|       9
---------------------------------------------------------------------------
  517-  527 (21.46/14.58)	VFVKLHRHPNV
  550-  560 (20.27/13.27)	VYVKPTRTENV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.77|      18|      34|     247|     269|      10
---------------------------------------------------------------------------
  247-  269 (20.84/27.28)	LQVNYIHQLiqaRLVdnQNALAE
  283-  300 (30.93/19.57)	LEVLYTQTL...RLI..RDRLHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.84|      17|      34|     672|     689|      12
---------------------------------------------------------------------------
  672-  689 (26.11/21.31)	LKLLtLPKPIPPQVDNKT
  704-  720 (27.72/17.11)	LKRL.LSVAVRAQVNRHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.77|      52|    1296|      66|     158|      19
---------------------------------------------------------------------------
   66-  158 (65.37/99.30)	FSARTRQL..FIRLLALvkWANSASkvdksaqimsfldkqsmLFVETADMLARmaretlvharlptfhipaaveiLTTGTYGRLPACIREKIVP.P
 1404- 1458 (87.39/48.19)	MSAVSHQLkrFAEYAAL..QPNECS.................LFPAVRDLLAN......................LILPTEPQLPPQIQNQIVPsP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09130 with Med14 domain of Kingdom Metazoa
Unable to open file!