<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09125

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKENKILKLIHIAWRERWSDSQFGINIKNFQMHLRTVMRKCIRCNALLSFVATVCKVSFAEFDGFLRLINSVGGSNNEGTNLAWDFDDDVVTTTRTKTMCCNYCPEFPKVVLPRGVSGDVYNLADSILQQALIGSTANPLVLNYLKHSLCAHLVSHAAVLRRIAKYEHFERLYCTTSLLDFLDSVIAGVTCRAKTEEAILPGALVSLINWLMQVFAMITAHYEIHRELNSEQSYMLGQCCLVIEKVIKNQFLMAIIYVGCHEDPDYYGQIRERYAAIKTSLTNSNFNPTHPSIEAYLHQLAYVDVHHLDMPLLDIQPKPEPVTYCVQPLLTVDVLLNPCNDTSYYVAKIQMVQRLKKFSNTRLFYEIVRAGFVSLSNVMETTHDTMWGAFTFFKVPQIIKQLQALNRAVGEQTPNDYIPEVVEAIELLLEDKLLLDFMDSKCSCNIIEYLLNDWTKQHLVNDMHVKHFAAQREGTSVLLQKRDASTQAPSIINFIIRAEVPLSGVLKTLSTDYNKVQEALLGVLCQVLVGNSFDLILSVATVEGRLKTFVSRLILCNENSKQVPGEMGKASIIRSTLFDVSFLMLTFIVQTYGSDAVLSNNGDSFFEKWVRECMVERNKPKNPRNMIVMCDENMVDELLLNLSKPEPQLKNINITWQDVCLNLPGVLYQVLIAWEKETLSSADVKNILDNIKRRLFSFSVCATSFLCAYMCSVKENELLKPLNMIQQFLAPPSAEEMSSQENIKERLGLSFQIIRKLQHDVRPTVNPKSRSITLVQNLVSQTPLMDQFRDVWRTVNENGWLPIRAAQILESLLHAGGAAWLTTRLLEEILKCKYIHDMMKTMDIVFAILHLDIELSTEALLTQVVPAMIQNRQGEDIDEPHLHVLARLCVYCIISAVETRHYTNFSYQKKRSRSHDGDDMDLNNTVKMRKINTDSSDNSSSNDFLGDSNLFNTHASTHLRNTPNQLKESLQNSIQYIFKIFQQFLQTDKLSLKFVSLLVECGQERVRLVLNLLPTNLINNLLKVMLTDQISVGLIARLYDLRTSCGRQAAVADLTLWRNLKLKEQSIHL
Length1069
PositionTail
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.08
Grand average of hydropathy-0.035
Instability index38.34
Isoelectric point6.65
Molecular weight121827.83
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09125
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.57|      18|     255|     167|     200|       1
---------------------------------------------------------------------------
  167-  184 (34.24/12.01)	EHFERLYCTTS.LLDFLDS
  423-  440 (28.61/ 7.40)	EAIELLLEDKL.LLDFMDS
  466-  480 (12.72/ 6.53)	KHFAAQREGTSvLLQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.39|      50|     150|     506|     556|       2
---------------------------------------------------------------------------
  506-  556 (79.23/51.57)	LKTLSTDYNKVQEALLGVLCQVLVGNSFDlILSVATVEGRLKTFVSRL.........ILC
  649-  707 (81.16/48.83)	LKNINITWQDVCLNLPGVLYQVLIAWEKE.TLSSADVKNILDNIKRRLfsfsvcatsFLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.79|      68|     370|     186|     263|       3
---------------------------------------------------------------------------
  186-  263 (100.78/101.79)	IAGVTCRAkteeAILPGALVSlINWLMQVFamITAHYEIHREL.NSEQSYM..LGQCCLVIEKVIKNQFLMAIIyvgCHED
  563-  633 (113.02/81.30)	VPGEMGKA....SIIRSTLFD.VSFLMLTF..IVQTYGSDAVLsNNGDSFFekWVRECMVERNKPKNPRNMIVM...CDEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     212.50|      72|     292|      44|     127|       6
---------------------------------------------------------------------------
   44-  127 (103.60/115.55)	CNALLSFVATVCKVS.FAEFDGfLRLINSVggsNNEG.TNLAwdfddDVVTTTRtKTMCCNYC.PEFPKVV.....LPRGVSGDVYNlaDSI
  339-  418 (108.90/79.49)	CNDTSYYVAKIQMVQrLKKFSN.TRLFYEI...VRAGfVSLS.....NVMETTH.DTMWGAFTfFKVPQIIkqlqaLNRAVGEQTPN..DYI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09125 with Med24 domain of Kingdom Metazoa
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