<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09120

Description Uncharacterized protein
SequenceMLSLLQEKRPLKRSRLGPPDVYPQEAKQREDELTPSNVNKGFASMPPLSDEFGTAHTSNVNASKVASFFNAILAKKEELMTLQDTVRKKQQINFKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTGNLIKFMKELLPKLQEYYHLCEKSSSSEKASLSGQGAPTTQNNNASLALSHSSNNATLVPSIASPIPMLSPANSQSSSSGGLGVLSSNSGSGVGTSSSQSSITGANQTPVSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRMEFLNWILELLDRMRTQANFDESLKRLVLTFALPYMQDFVQSERLCRKMAYIVAKKLTNLLNAVIDQQQPLTNGKSENTTHMEMDEEIDKKKTQLDPYEVAINEYLNCPHHRDIILYLSTILQVITVECPTAMVWCGIGENRAPAALCGSPLDHLPVAPSILPMPIKCPVTNAEVRRQLRATEAEIVLRSKHAENRWFAEKWQNANKNSYTHVLSILDYLDTHCFDRMDQTNSIDSLYANIFKTFVTIRREVGPNGEIKEIRHEYDANVVDGNTVRILCEWAVSSQRWGEHRAIVVALLLDKRQIEVTTPNEPDNNIGNAVAHSNNNLNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGGMTNRTQFTNLVHLFSALIRYDVFSHNAYMHTLISRGDLLEGVANVDSSKPSVTATTTVSGPVSNKASSPPVNQGFDDDFGTSMDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDTSNSIGCDNANSSISRHYIYTKHFPIPQDDPTTSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNAFALGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPELENQLQAKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFDGLCRTIKHVTNPSECSSAERCILAYLSDLYESCFLLKTKEQEPEFFQQMAAIKKFKDIFNAPEQLGIVPQAYNPQFLQELFTSPKRGGKIDSIWLHQLHESPSNVYSFVSNAIVAVCHEADNDRLNDIAISCAELTAGCNALSEEWIAALQSICNAMKKPRYPHFCQVDIQNSKIHNSLAVFICILVARHCFSLADFVMNFALPTLANAYPVGGEISADAEAGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLTTVGSSSNIKLSCDRHLLIGAHKNVPLEAVLAVLKAILIVVDTTALKTSNMSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLSQILGTSDLNSLNTEHDHDMTQQLTSTPSNTGALNNSEQISLLEFAQHVLKQICAQEHVLERCLKNAEKLCDMIIDEMLTPKQVQRILHMICYPESEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHRQSMNNPAELSSWLDTVARAAIDVFLMEEVVVASGLKSEHRPKASTWLVAPLVAKLTPAVQGRILRVAGQVLESMSYFSKVSKSDNNSSCSGDEREKSNSCGSASSSYSIGVNGSNSRSRKMPLNYQPFLGLILTCLKSQDEYKEGLLCSLYSQLSQCLQSYTEFDTMGGVDDPLGREEMLDALQLRFSLVGGMFESIQKNGTSITDWAILLAQLVCQGVVDLSTNKELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEALPLPPEDIEPIAEKIVTPTLFLQKDEMKADTPSSVDQSPSAVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTGHNPQQQQWPGQNQFHPMQQQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQNLGTQNPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNANIMTSQNNTGLVSASAMMQQNVGVGGGAVGQNMVNQNAGQFQNFSQYQHQTINQSGNTNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGAVPPYSRQQTSGGKPGVVSTQQQFQQQQRLQHQMMQMQGIGPQNNGASGMTQPQNQSVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
Length2388
PositionKinase
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.456
Instability index48.39
Isoelectric point6.50
Molecular weight265489.51
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09120
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     133.40|      21|      21|    2150|    2170|       1
---------------------------------------------------------------------------
 2005- 2030 (31.52/11.69)	HNPQQQ.QWpgqnqfHPM.QQQQQQQQQ
 2068- 2088 (27.47/ 9.18)	MN.QNNSAA.....fNTM.QQQQRQTQG
 2141- 2161 (26.02/ 8.27)	MGSQN......lgtqNPI.MQQQISAQT
 2162- 2178 (23.05/ 6.42)	MNPQNNNQM.........iMNQN..AGV
 2335- 2352 (25.35/ 7.86)	IGPQNNGAS......G.M.TQPQ..NQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     187.36|      22|      23|    2222|    2243|       2
---------------------------------------------------------------------------
 1971- 1994 (27.51/10.42)	PsgiQQ..QMNVGN.SQQSSQMGFMGS
 2222- 2243 (40.80/19.51)	N...QN..AGQFQNFSQYQHQTINQSG
 2246- 2264 (29.12/11.52)	N...QQ..ANIVANFMAQQQQ...QQP
 2265- 2288 (28.48/11.09)	P...QRgpAGMTSNRGQYMSQAPNVTM
 2289- 2307 (27.53/10.43)	N...ST..MGQ.GAVPPYSRQ..QTSG
 2313- 2334 (33.92/14.81)	V...ST..QQQFQQQQRLQHQMMQMQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.31|      22|      23|    1470|    1491|       3
---------------------------------------------------------------------------
 1433- 1465 (17.82/ 6.74)	.QHVLKQICAQEhvlerclknAEklcDMI.IDEML
 1470- 1491 (40.86/24.91)	VQRILHMICYPE.........SE...YNI.ISELD
 1496- 1514 (25.63/12.90)	IVRILENL.............GQ...WTLrISWLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.70|      21|      23|     258|     278|       4
---------------------------------------------------------------------------
  258-  278 (37.08/16.24)	SQSSSSGGLGV.LSSNSGSGVG
  282-  303 (32.61/13.53)	SQSSITGANQTpVSGSSISGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      80.74|      11|      17|    1936|    1946|       5
---------------------------------------------------------------------------
 1936- 1946 (19.22/ 9.01)	QSPSAVVNMQQ
 1955- 1965 (21.45/11.10)	QNPNAIIQQQQ
 2357- 2367 (19.60/ 9.37)	QTPNLVAHLQQ
 2373- 2382 (20.47/10.18)	Q.PNMMGQQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.90|      36|     421|     204|     248|       6
---------------------------------------------------------------------------
  204-  239 (58.96/24.67)	LCEKSSSS.EKASLSGQGA.................PTTQNNNASLALSHSSNN
  612-  661 (52.99/20.96)	LCEWAVSS.QRW...GEHRaivvallldkrqievttPNEPDNNIGNAVAHSNNN
  831-  864 (44.95/18.44)	.CDNANSSiSRHYIYTKHF.................PIPQDDPTTSYSSESN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.03|      30|     421|     538|     571|       7
---------------------------------------------------------------------------
  538-  571 (47.91/35.29)	NA...NKNSYTHVLSILDYLdthcFDRMDQTNSIDSL
  950-  982 (49.12/26.10)	NAfalGSNNYLPVQEHVAFL....FDLMEMALNIHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.47|      20|     128|    1689|    1708|       8
---------------------------------------------------------------------------
 1689- 1708 (35.29/24.62)	GVDDPLGREEMLDALQLRFS
 1819- 1838 (35.18/24.52)	GVDQKGNKINDMDKKQLRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      15|      19|    1108|    1126|       9
---------------------------------------------------------------------------
 1108- 1126 (21.38/18.79)	GIVPQAYnpqfLQELFTSP
 1130- 1144 (28.66/13.67)	GKIDSIW....LHQLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.22|      85|     250|      87|     179|      12
---------------------------------------------------------------------------
   87-  179 (127.64/134.03)	RKKQQINFKDNFWPVSprTKGALdAWFKDLAGNKPLLSlaKKAPSFNKKeeiLITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDP
  347-  431 (142.58/117.32)	RMRTQANFDESLKRLV..LTFAL.PYMQDFVQSERLCR..KMAYIVAKK...LTNLLNAVIDQQQPLTNGKSENTTHMEMDEEIDKKKTQLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.29|      21|     252|    1410|    1431|      30
---------------------------------------------------------------------------
 1410- 1431 (32.19/17.57)	LTsTPSNTGALN..NSEQISLLEF
 2089- 2111 (33.10/14.28)	LT.TQSQTGVLNpvQQQQLQQQQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.30|      16|     128|    1718|    1742|      31
---------------------------------------------------------------------------
 1722- 1740 (20.82/29.20)	TSITDwaiLLAQLVCQGVV
 1750- 1765 (25.47/ 8.80)	TTVVD...MLTTLVHSTLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09120 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPSVTATTTVSGPVSNKASSPPVNQGFDDD
2) KRSRLGPPDVYPQEAKQREDELTPSNVNKGF
3) MSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLS
4) TLFLQKDEMKADTPSSVDQSPSAVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTGHNPQQQQWPGQNQFHPMQQQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQNLGTQNPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNANIMTSQNNTGLVSASAM
5) VGVGGGAVGQNMVNQNAGQFQNFSQYQHQTINQSGNTNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGAVPPYSRQQTSGGKPGVVSTQQQFQQQQRLQHQMMQMQGIGPQNNGASGMTQPQNQSVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
751
12
1348
1918
2209
780
42
1387
2204
2388










Molecular Recognition Features






MoRF SequenceStartStop




1) KRPLKRSRL
2) RYILLF
8
866
16
871