<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09120

Description Uncharacterized protein
SequenceMLSLLQEKRPLKRSRLGPPDVYPQEAKQREDELTPSNVNKGFASMPPLSDEFGTAHTSNVNASKVASFFNAILAKKEELMTLQDTVRKKQQINFKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTGNLIKFMKELLPKLQEYYHLCEKSSSSEKASLSGQGAPTTQNNNASLALSHSSNNATLVPSIASPIPMLSPANSQSSSSGGLGVLSSNSGSGVGTSSSQSSITGANQTPVSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRMEFLNWILELLDRMRTQANFDESLKRLVLTFALPYMQDFVQSERLCRKMAYIVAKKLTNLLNAVIDQQQPLTNGKSENTTHMEMDEEIDKKKTQLDPYEVAINEYLNCPHHRDIILYLSTILQVITVECPTAMVWCGIGENRAPAALCGSPLDHLPVAPSILPMPIKCPVTNAEVRRQLRATEAEIVLRSKHAENRWFAEKWQNANKNSYTHVLSILDYLDTHCFDRMDQTNSIDSLYANIFKTFVTIRREVGPNGEIKEIRHEYDANVVDGNTVRILCEWAVSSQRWGEHRAIVVALLLDKRQIEVTTPNEPDNNIGNAVAHSNNNLNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGGMTNRTQFTNLVHLFSALIRYDVFSHNAYMHTLISRGDLLEGVANVDSSKPSVTATTTVSGPVSNKASSPPVNQGFDDDFGTSMDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDTSNSIGCDNANSSISRHYIYTKHFPIPQDDPTTSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNAFALGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPELENQLQAKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFDGLCRTIKHVTNPSECSSAERCILAYLSDLYESCFLLKTKEQEPEFFQQMAAIKKFKDIFNAPEQLGIVPQAYNPQFLQELFTSPKRGGKIDSIWLHQLHESPSNVYSFVSNAIVAVCHEADNDRLNDIAISCAELTAGCNALSEEWIAALQSICNAMKKPRYPHFCQVDIQNSKIHNSLAVFICILVARHCFSLADFVMNFALPTLANAYPVGGEISADAEAGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLTTVGSSSNIKLSCDRHLLIGAHKNVPLEAVLAVLKAILIVVDTTALKTSNMSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLSQILGTSDLNSLNTEHDHDMTQQLTSTPSNTGALNNSEQISLLEFAQHVLKQICAQEHVLERCLKNAEKLCDMIIDEMLTPKQVQRILHMICYPESEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHRQSMNNPAELSSWLDTVARAAIDVFLMEEVVVASGLKSEHRPKASTWLVAPLVAKLTPAVQGRILRVAGQVLESMSYFSKVSKSDNNSSCSGDEREKSNSCGSASSSYSIGVNGSNSRSRKMPLNYQPFLGLILTCLKSQDEYKEGLLCSLYSQLSQCLQSYTEFDTMGGVDDPLGREEMLDALQLRFSLVGGMFESIQKNGTSITDWAILLAQLVCQGVVDLSTNKELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEALPLPPEDIEPIAEKIVTPTLFLQKDEMKADTPSSVDQSPSAVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTGHNPQQQQWPGQNQFHPMQQQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQNLGTQNPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNANIMTSQNNTGLVSASAMMQQNVGVGGGAVGQNMVNQNAGQFQNFSQYQHQTINQSGNTNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGAVPPYSRQQTSGGKPGVVSTQQQFQQQQRLQHQMMQMQGIGPQNNGASGMTQPQNQSVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
Length2388
PositionKinase
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.456
Instability index48.39
Isoelectric point6.50
Molecular weight265489.51
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09120
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     133.40|      21|      21|    2150|    2170|       1
---------------------------------------------------------------------------
 2005- 2030 (31.52/11.69)	HNPQQQ.QWpgqnqfHPM.QQQQQQQQQ
 2068- 2088 (27.47/ 9.18)	MN.QNNSAA.....fNTM.QQQQRQTQG
 2141- 2161 (26.02/ 8.27)	MGSQN......lgtqNPI.MQQQISAQT
 2162- 2178 (23.05/ 6.42)	MNPQNNNQM.........iMNQN..AGV
 2335- 2352 (25.35/ 7.86)	IGPQNNGAS......G.M.TQPQ..NQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     187.36|      22|      23|    2222|    2243|       2
---------------------------------------------------------------------------
 1971- 1994 (27.51/10.42)	PsgiQQ..QMNVGN.SQQSSQMGFMGS
 2222- 2243 (40.80/19.51)	N...QN..AGQFQNFSQYQHQTINQSG
 2246- 2264 (29.12/11.52)	N...QQ..ANIVANFMAQQQQ...QQP
 2265- 2288 (28.48/11.09)	P...QRgpAGMTSNRGQYMSQAPNVTM
 2289- 2307 (27.53/10.43)	N...ST..MGQ.GAVPPYSRQ..QTSG
 2313- 2334 (33.92/14.81)	V...ST..QQQFQQQQRLQHQMMQMQG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.31|      22|      23|    1470|    1491|       3
---------------------------------------------------------------------------
 1433- 1465 (17.82/ 6.74)	.QHVLKQICAQEhvlerclknAEklcDMI.IDEML
 1470- 1491 (40.86/24.91)	VQRILHMICYPE.........SE...YNI.ISELD
 1496- 1514 (25.63/12.90)	IVRILENL.............GQ...WTLrISWLD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.70|      21|      23|     258|     278|       4
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  258-  278 (37.08/16.24)	SQSSSSGGLGV.LSSNSGSGVG
  282-  303 (32.61/13.53)	SQSSITGANQTpVSGSSISGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      80.74|      11|      17|    1936|    1946|       5
---------------------------------------------------------------------------
 1936- 1946 (19.22/ 9.01)	QSPSAVVNMQQ
 1955- 1965 (21.45/11.10)	QNPNAIIQQQQ
 2357- 2367 (19.60/ 9.37)	QTPNLVAHLQQ
 2373- 2382 (20.47/10.18)	Q.PNMMGQQYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.90|      36|     421|     204|     248|       6
---------------------------------------------------------------------------
  204-  239 (58.96/24.67)	LCEKSSSS.EKASLSGQGA.................PTTQNNNASLALSHSSNN
  612-  661 (52.99/20.96)	LCEWAVSS.QRW...GEHRaivvallldkrqievttPNEPDNNIGNAVAHSNNN
  831-  864 (44.95/18.44)	.CDNANSSiSRHYIYTKHF.................PIPQDDPTTSYSSESN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.03|      30|     421|     538|     571|       7
---------------------------------------------------------------------------
  538-  571 (47.91/35.29)	NA...NKNSYTHVLSILDYLdthcFDRMDQTNSIDSL
  950-  982 (49.12/26.10)	NAfalGSNNYLPVQEHVAFL....FDLMEMALNIHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.47|      20|     128|    1689|    1708|       8
---------------------------------------------------------------------------
 1689- 1708 (35.29/24.62)	GVDDPLGREEMLDALQLRFS
 1819- 1838 (35.18/24.52)	GVDQKGNKINDMDKKQLRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      15|      19|    1108|    1126|       9
---------------------------------------------------------------------------
 1108- 1126 (21.38/18.79)	GIVPQAYnpqfLQELFTSP
 1130- 1144 (28.66/13.67)	GKIDSIW....LHQLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.22|      85|     250|      87|     179|      12
---------------------------------------------------------------------------
   87-  179 (127.64/134.03)	RKKQQINFKDNFWPVSprTKGALdAWFKDLAGNKPLLSlaKKAPSFNKKeeiLITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDP
  347-  431 (142.58/117.32)	RMRTQANFDESLKRLV..LTFAL.PYMQDFVQSERLCR..KMAYIVAKK...LTNLLNAVIDQQQPLTNGKSENTTHMEMDEEIDKKKTQLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.29|      21|     252|    1410|    1431|      30
---------------------------------------------------------------------------
 1410- 1431 (32.19/17.57)	LTsTPSNTGALN..NSEQISLLEF
 2089- 2111 (33.10/14.28)	LT.TQSQTGVLNpvQQQQLQQQQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.30|      16|     128|    1718|    1742|      31
---------------------------------------------------------------------------
 1722- 1740 (20.82/29.20)	TSITDwaiLLAQLVCQGVV
 1750- 1765 (25.47/ 8.80)	TTVVD...MLTTLVHSTLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09120 with Med12 domain of Kingdom Metazoa
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