<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09117

Description Mediator of RNA polymerase II transcription subunit 13
SequenceQQQQQQQPQQQQQHSQHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASAGDVKLESTGLQLNPTVSSASSTSHSHSHSHSTTTLNAMLPNSLKRNSSTQGSAGNSIHAMHDFLNLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSYHTIKRFKPNDLSKPCRIMRTKNLYEGHTHIKPLMPSPRSVYGNQLLAADSVQAAQIASVSGADSSTFMADMSGGLVGIASNNQNISRLANDNSAGPLTTVGSSTTSNFFEELDIKTEMMSGTASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAISNTAIDDLKRSTNPAILGNSNVAIANSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGSNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSKYAPLTNLPSQTMAPLIAPPNCIYKPSWQPTRSTHQQPQQQQQLQQHNQSLQQQQNHQQQQPQHQQHQQLHELLSSAPRTPLQQPRTPLGPMSSSPMHNTVPTPLSSGGGGGGSLLLNQLNCPQAALTNTPSAMQQLMQRAGMSPVSPAPHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPSASLGLFSGTVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGVYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFTSKSNGTNGTNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTTIANVLEYMDANDIISLALEQARLAFDSSRVDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYMPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTLMCGWGGMLTVSQRPPTEKPYTTNMDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPSDKSLLNPPDANIHAGSHNNTRLNATGNTSSPMAGTITGLENSDRGDHASSTPMEHGDLSQHATTDTSGNINDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPDSVRANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDDQNRRPYKMYTPPYILAPIHEKNEKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVLGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPSWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length1909
PositionMiddle
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.408
Instability index53.26
Isoelectric point6.19
Molecular weight208150.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09117
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.17|      20|      21|     526|     546|       1
---------------------------------------------------------------------------
    2-   19 (41.00/22.76)	QQQQ...QQPQQQQQHSQHQQ
  526-  546 (37.87/25.00)	QPTRStHQQPQQQQQLQQHNQ
  549-  566 (41.31/22.99)	QQQQN.HQ..QQQPQHQQHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.14|      21|      26|      71|      91|       2
---------------------------------------------------------------------------
   71-   91 (38.98/24.46)	SSTSHSHSHS.HST.TTLNAMLP
   98-  120 (30.16/16.97)	SSTQGSAGNSiHAMhDFLNLYKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.57|      28|      28|     790|     817|       4
---------------------------------------------------------------------------
  790-  817 (49.91/23.29)	GNIRGADSGVYVPLPGTSFNPSPLTSSA
  821-  848 (51.66/24.35)	GNIRALSAFGAVSSGGGGGIGSALDSPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     427.87|     120|     314|     284|     404|       5
---------------------------------------------------------------------------
  167-  235 (77.74/34.89)	..........................................PCRimRTKNLYEGHTH.IKPLMPSPRSVygNQLL...AADSVQAAQI............................A....SVSGADSST.FMA.DMSGGLVGIASNN
  242-  380 (178.60/93.40)	ANDNSAGPLTTVgsSTTSNFFEELDIktemmsgtasgtssisPCK..DSKSGIGGNLFTVEGLNPSPNDL..EQLFETSSNDECSSVQIHTPPDSNNPSNGCAIsNTAIDDLKRSTNP....AILGNSNVA.IAN.STAGAAVMVALQN
  381-  518 (171.54/86.24)	CNNSSASSTSAV..SSLNNSVGNISG..ganiiqaedltkmfPTP..PSHEQHHPNSSPCQ.MDIHMTDL..SVITNLGSNLD.SGLGMLKIKQEYSIELGSPI.EEPIEDWSYVYRPpqqaKFVGSSKYApLTNlPSQTMAPLIAPPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.61|      13|      21|     642|     656|       6
---------------------------------------------------------------------------
  642-  656 (23.83/14.80)	PVSPAPhvPF..PHTSP
  666-  680 (23.78/ 8.86)	PIHPPP..PYevAVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.88|      50|     437|    1254|    1360|       7
---------------------------------------------------------------------------
 1305- 1360 (75.65/114.21)	ENSDRGDHASSTPMEHGDLSQHATTDtsgNINDNKGTDVKpDVKPplVLGDPLGVG
 1745- 1794 (91.24/32.70)	ENRGISDHNSPDRMEDNRSWQSAGGN...NFNSAQQQDVE.EVGS..INQQPLAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     305.86|      95|     518|    1091|    1190|       8
---------------------------------------------------------------------------
 1091- 1190 (158.12/106.55)	HS..KSRSAAGAKDATYTVSgpltwRQFHRLAGRASGQCEPQPIPSVIVGHDKD.WISVAPLAIHYWDKF....LLEPYSYARDV..VYLVIAPDNDYVISKTKTYFKE
 1610- 1713 (147.73/88.17)	HSelKSWSALLSKQNLQKAT.....KQLKDMCKQCQLMYPPSILSACLVTLEPDaKLRVMPDQFTPDERFsqisIQNPLSTPQDVtcTHILVFPTSAVCLSFTRQFQNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.92|      10|     460|     271|     280|       9
---------------------------------------------------------------------------
  271-  280 (19.47/10.39)	MMSGTASGTS
  732-  741 (18.46/ 9.44)	LFSGTVSNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.62|      16|      26|      23|      40|      11
---------------------------------------------------------------------------
   23-   40 (22.44/22.11)	GTITVKRFDLQptLPATV
   52-   67 (27.18/17.77)	GDVKLESTGLQ..LNPTV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09117 with Med13 domain of Kingdom Metazoa
Unable to open file!