<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09108

Description Mediator of RNA polymerase II transcription subunit 11
SequenceMNPLGKIQVLDDIEKEIIQCLQSAGQTLQELSKEKSSQKNAETQTQQFLKSLSSLESKLTEQISYLTQVSTGQPHEGSGYASAKLTASTANDNVKNNFSFLKQTWSWKEKETNIKTKNNFLPSSAISLLKSRKHGSTYPDEYSDQSSNTQMNEIRKTEKQHCESCELDFQSPEDLKVHRLQHEKCPVDSCKFWGHSTIMDKHVLVLHSSGLFDKFKKLSTPEEIATWREERRRRYPTVANVLLKQKALEQKQKRGERLEINKSRFGRAESRKRTKPWISKENSANEDLPRRSNFKKRRKRQKDTKPKSSNVKTKLHQPPKQTQEQIEHGKEDLRIVCAFEGTAKMEDYKHFSQKRTNANVLYNLLGMYGSDSESENCDNEASVHLNCSNSMCIENVATSVSNNNECVNSSEGQGKNASFHVKEKGNASQNLTTNFETDSKQNVIAINAGECTAENEDRVVQDLSPKFNQPTTQNAKVKSEGDFPQRDGESSDGAPEECPIQHSADYSNMPLKVEDKVPQQAPSFRREQRKKKPAFNLNKVRLRKQNTMLEKLLEPDIRHERNLLLQCVRFVCEQNFFGIGQIPK
Length584
PositionHead
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-1.040
Instability index51.85
Isoelectric point9.02
Molecular weight66750.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364147

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09108
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.40|      16|      16|     289|     304|       1
---------------------------------------------------------------------------
  289-  304 (28.55/16.23)	PRRSNFK.KRRKRQKDT
  306-  322 (22.85/11.59)	PKSSNVKtKLHQPPKQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.00|      16|      16|      22|      37|       2
---------------------------------------------------------------------------
    8-   25 (19.76/11.35)	QVLDDIEKEiiQCLQSAG
   26-   41 (25.24/16.72)	QTLQELSKE..KSSQKNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.73|      15|      20|      84|      98|       3
---------------------------------------------------------------------------
   84-   98 (26.43/20.01)	KLTAS....TANDNVKNNF
  102-  120 (23.29/16.63)	KQTWSwkekETNIKTKNNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.41|      16|      22|     375|     390|       4
---------------------------------------------------------------------------
  375-  390 (30.60/18.88)	ENCDNEASVHLNCSNS
  394-  409 (25.80/14.83)	ENVATSVSNNNECVNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.69|      15|      22|     153|     167|       5
---------------------------------------------------------------------------
  153-  167 (26.56/13.82)	EIRKTEKQHC..ESCEL
  176-  192 (23.12/11.21)	KVHRLQHEKCpvDSCKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.37|      14|      29|     429|     442|       6
---------------------------------------------------------------------------
  413-  426 (22.14/11.73)	QGKNASFHVKEKGN
  429-  442 (23.11/12.55)	QNLTTNFETDSKQN
  461-  474 (24.12/13.41)	QDLSPKFNQPTTQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      47.13|      10|      37|     229|     238|       7
---------------------------------------------------------------------------
  229-  238 (16.22/ 8.09)	EERRRRYPTV
  259-  268 (14.31/ 6.31)	EINKSRFGRA
  269-  278 (16.60/ 8.44)	ESRKRTKPWI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09108 with Med11 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ENEDRVVQDLSPKFNQPTTQNAKVKSEGDFPQRDGESSDGAPEECPIQHSADYSNMPLKVEDKVPQQAPSFRREQRKKKPAFNLNKV
2) ESRKRTKPWISKENSANEDLPRRSNFKKRRKRQKDTKPKSSNVKTKLHQPPKQTQEQIEHG
3) NNECVNSSEGQGKNASFHVKEKGNASQNLTTNFETDS
454
269
403
540
329
439










Molecular Recognition Features






MoRF SequenceStartStop




NANANA