<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09105

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDDWQSQQFRQSAIAKIKDLLQASGQHLDKNANVMENHIFKKSKSKEEYMTLLTKIYSHFKENSRKLTNEISQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGGVPGQQQNVVGGPSSQQQMMNQMVGPGGLQMNIMGGPGGPQQNQMVGNAQQMTAGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQTGPGGNITVGAGPTGGAAQGMQGLPGNLQQNQGAGAVSQMHSGNVSGGPQVPSSAMGNNAGQGNLNQMLNMPPGMQKNPNMPLAQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLTVQQQQQQQQLQQVVNNQQQLQQQQQQQANQTGGPQSNQALPNAQMIPSPALVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKYKQLTKYIEPLKRMVAKFSNDGAQIEGQTKMRKLLEILSNPSQRVSLETLLKCEKVLEKMEIGNIVQQFGKSPNPLMEVITNTLQSPIANHTLYRTFRPTLELLLGTDICAPPPLKKSKTTNSNETEIPHLLQGELARLDTKFKVSLDTTVQNNTQSIKLICCLDDKKLPSVPPININIPEEYPLSSPDCILIEQDYTCTSFLKSVQSAFTARIAKLPKLYSLSHLLNTWEMSVRQACSPNASKPICELTALFGM
Length764
PositionTail
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.03
Grand average of hydropathy-0.648
Instability index58.25
Isoelectric point9.38
Molecular weight82710.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09105
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     542.65|      73|      73|     211|     283|       3
---------------------------------------------------------------------------
   93-  138 (61.12/11.71)	NRNpQMMSMG.GGP...........GGPvtasN....................LLQ...S.............LN.QQR..P.GQ....QQ....MQQMqGMR.....PQM.....................
  139-  208 (62.02/12.00)	.............P......MGGGV..P....G....................QQQ......NVVGGPSSQQQM.MNQMvgP.GGL....Q....MNIM.GGPGGPQQNQMvgnaqqmtaggsgpgvgqgLG
  211-  283 (156.12/41.67)	QMN.QMVGPGSGGP......MGSGAGGP....N....................QMQMQAAAGQMQGGPMNVHGMNVQQL..P.GQM.PQQQ....MQQM.SMQQHSQLNQM...................MN
  285-  332 (67.33/13.67)	RMN.Q.TGPG..GN......ITVGA.GP...............................TGGAAQG..M.......QGL..P.GNL.QQNQgagaVSQM.....HSG.N.......................
  333-  379 (63.88/12.58)	.........VSGGPqvpssaMGNNAGQG....N...........................LNQMLNMP...PGM..QKN..P..NM.P.............LAQN...NQM...................FN
  387-  475 (85.41/19.37)	QQQ.FLRQSPSPST......VSSPAGGL....TvqqqqqqqqlqqvvnnqqqlQQQQQQQANQ.TGGPQS....N.QAL..PnAQMiPSPA....LVPT.SSPQMSGLMQN...................PN
  478-  513 (46.77/ 7.19)	QMR.Q..SPSS..N......L...........N..........................TPGQVANSPFNPH.........E.EQL.YREK....YKQL.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.95|      32|      45|     543|     583|       4
---------------------------------------------------------------------------
  520-  561 (43.68/28.25)	LKRM.....VAKFSNDGAqiegqtkmrkLLEILSNPSQ.RVSLETLLK
  566-  604 (41.27/27.66)	LEKMeigniVQQFGKSPN.........pLMEVITNTLQsPIANHTLYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.97|      58|      86|     612|     673|       5
---------------------------------------------------------------------------
  612-  673 (87.96/72.39)	LLLGTDICAPPPLKKSKTTNSNE.TEIPHLLQgeLARLDTKFKVSLDTTVQNNTQsiKLICCL
  700-  758 (95.00/65.01)	ILIEQDYTCTSFLKSVQSAFTARiAKLPKLYS..LSHLLNTWEMSVRQACSPNAS..KPICEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.87|      20|      29|      21|      40|       6
---------------------------------------------------------------------------
   21-   40 (33.93/25.88)	LLQASGQHLDKNANVMENHI
   53-   72 (32.94/24.90)	LLTKIYSHFKENSRKLTNEI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09105 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSRKLTNEISQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGGVPGQQQNVVGGPSSQQQMMNQMVGPGGLQMNIMGGPGGPQQNQMVGNAQQMTAGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQTGPGGNITVGAGPTGGAAQGMQGLPGNLQQNQGAGAVSQMHSGNVSGGPQVPSSAMGNNAGQGNLNQMLNMPPGMQKNPNMPLAQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLTVQQQQQQQQLQQVVNNQQQLQQQQQQQANQTGGPQSNQALPNAQMIPSPALVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKY
64
510










Molecular Recognition Features






MoRF SequenceStartStop




NANANA