<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09102

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQEQTSPNNSPIVAEATGENSAANANGSNMPKPRKVILAPFGMAATLTGNSYKANDPMAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNNGDNLSSNVRKPLTETVSNKLTTTTTTITTTTTPTPTNTNQTASSKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANTAISANFNENISVIGNGGSNGGSGSVGGGGGGGGGNASIGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTNKGFVGFLKGKFDGKETRREGGGNGKKKGSFKLSMNNLCETMSRQLHDGGRQSVKIPFNGSNSSSSSSSNSSSVGNSLAHHVLAQLSSNSHIHINNQQLSIASGSSIGHNNQSCIPSTEMSKVCTKTNTLLRIHRIPPFHKRHLFESDGKDYWLIGNNSTNSKITISSSCFIDSNQKQQQTNYPRAALYQNSACTSEITRKQRSLAAQHHHPAAATTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPASVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASLAAQHHHPAAATTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPASVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNIIGGTGGGGGGGGGGGGGAGGVVGGPNLNENMQSSGIVGGTNQPASVGRCTPTIQQQQSSSQQQHQQQQPQPHQQQQQQPPQQQQQQQHQQQQQQQPQQQQQHSQHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASAGDVKLESTGLQLNPTVSSASSTSHSHSHSHSTTTLNAMLPNSLKRNSSTQGSAGNSIHAMHDFLNLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSYHTIKRFKPNDLSKPCRIMRTKNLYEGHTHIKPLMPSPRSVYGNQLLAADSVQAAQIASVSGADSSTFMADMSGGLVGIASNNQNISRLANDNSAGPLTTVGSSTTSNFFEELDIKTEMMSGTASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAISNTAIDDLKRSTNPAILGNSNVAIANSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGSNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSNGGGGGGSLLLNQLNCPQAALTNTPSAMQQLMQRAGMSPVSPAPHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPSASLGLFSGTVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGVYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFTSKSNGTNGTNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTTIANVLEYMDANDIISLALEQARLAFDSSRVDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYMPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTLMCGWGGMLTVSQRPPTEKPYTTNMDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPSDKSLLNPPDANIHAGSHNNTRLNATGNTSSPMAGTITGLENSDRGDHASSTPMEHGDLSQHATTDTSGNINDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPDSVRANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDDQNRRPYKMYTPPYILAPIHEKNEKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVLGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPSWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2762
PositionMiddle
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.452
Instability index52.14
Isoelectric point6.31
Molecular weight296772.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09102
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     311.25|      35|      35|     651|     685|       1
---------------------------------------------------------------------------
  633-  653 (26.50/ 6.71)	...P.LQGANG.GASSY..SRNS...............vmDTM
  654-  689 (73.05/32.56)	P.VP.SVGSPGTPAPSP..HPNSTLSQPTSV.P.PADQ.lLAM
  691-  723 (36.69/12.37)	PrAPaSVSNLQQP.PTPieH...LLDKNTPA.PtPTDQ.....
  751-  771 (33.50/10.60)	...P.LQGANG.GASSY..SRNSVM...............DTM
  772-  807 (73.05/32.56)	P.VP.SVGSPGTPAPSP..HPNSTLSQPTSV.P.PADQ.lLAM
  809-  841 (36.69/12.37)	PrAPaSVSNLQQP.PTPieH...LLDKNTPA.PtPTDQ.....
 1498- 1523 (31.77/ 9.64)	P.AP.HVPFPHT...SPmmHHQ...QRQTPIhP.P........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.90|      19|     115|     614|     632|       2
---------------------------------------------------------------------------
  614-  632 (42.85/26.92)	SLAAQHHHPAAATTPGHGT
  732-  750 (42.85/26.92)	SLAAQHHHPAAATTPGHGT
 1577- 1589 (18.21/ 6.05)	......HHPSASLGLFSGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.82|      19|      19|     943|     961|       3
---------------------------------------------------------------------------
  925-  944 (34.10/18.98)	QQQQSSSQQQHQQQQPQpH.Q
  945-  961 (32.24/17.47)	QQQQQPPQQQQQQQH....qQ
  962-  980 (40.48/24.17)	QQQQQPQQQQQHSQHQQ.Q.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     524.58|     102|     115|    1156|    1270|       4
---------------------------------------------------------------------------
  334-  409 (69.94/25.01)	.....AISANFNENIS.VIGNGGSNGGSGSVGGGGGGGGGNASIGdcggeqqADIKPNtlaLLQKQQIWDFVDpTQKAPCIC....................................
  857-  900 (60.00/19.98)	PSVEPPPSVEGIHNIIGGTGGGGGGGG.....GGGGGAGGV..VG.......G...PN...LNE......................................................
 1169- 1270 (160.07/72.35)	ASVSGADSSTFMADMSGGLVGIASNNQNISRLANDNSAGPLTTVG.......SSTTSN...FFEELDIKTEMM.SGTASGTSSISPCKDSKSGI..GGNLFTVEGLN...PSPNDLEQ
 1294- 1385 (123.41/50.07)	PSNGCAISNTAIDDL........KRSTNPAILGNSNVAIANSTAG.......AAVMVA.......LQ...NCN.NSSASSTSAVSSLNNSVGNIsgGANIIQAEDLTkmfPTPPSHEQ
 1687- 1765 (111.17/45.90)	...............SGGGGGIGSALDSPASLAGAGSSS..STTP.......STTTPA...SNGQQHITGYVD.DDSVECTCGFSSVINRRLAY..GAGLFYEDELE...IT......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      30|    1030|    1058|       6
---------------------------------------------------------------------------
 1030- 1049 (26.19/ 9.76)	SSTSHSHSHSHSttTLNAML
 1061- 1078 (32.88/22.00)	GSAGNSIHAMHD..FLNLYK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.22|      25|      38|     432|     468|       7
---------------------------------------------------------------------------
  432-  456 (44.43/41.62)	GGNGKKKGSFKLSM..NNLCETMSRQL
  470-  496 (35.79/11.28)	GSNSSSSSSSNSSSvgNSLAHHVLAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.62|      27|     139|      69|      96|      10
---------------------------------------------------------------------------
   69-   96 (42.01/26.43)	SEAAAAFTTVaASSNNSQEQTSPNNSPI
  210-  236 (44.61/24.03)	SAEAAALTTL.SSVNNGDNLSSNVRKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.95|      50|     449|    2107|    2213|      13
---------------------------------------------------------------------------
 2158- 2213 (75.67/100.38)	ENSDRGDHASSTPMEHGDLSQHAttdTSGNINDNKGTDVKpDVKPplVLGDPLGVG
 2598- 2647 (91.28/28.28)	ENRGISDHNSPDRMEDNRSWQSA...GGNNFNSAQQQDVE.EVGS..INQQPLAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.48|      12|      21|     578|     589|      16
---------------------------------------------------------------------------
  578-  589 (21.85/13.89)	SSCFIDSNQKQQ
  602-  613 (20.63/12.63)	SACTSEITRKQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.71|      17|      31|    1087|    1103|      18
---------------------------------------------------------------------------
 1087- 1103 (30.57/17.35)	IDSFANDD....C..LKLDVLYD
 1115- 1137 (22.14/10.60)	IKRFKPNDlskpCriMRTKNLYE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09102 with Med13 domain of Kingdom Metazoa
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