<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09092

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPAPQPLEQALAGYLPQGQEGSSRMNTISLSVLIDFTIQRTYHDLTVLAELLPRKSDMERKIEIYNFSARTRQLFIRLIALVKYANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDPITPQEKKQTLLRLNQVIQHRLVTGKLMPQMREFKIRNGRVIFEVKHEFNVSLTVMGDNANVPWRLLDIDILVEDKETGDGKALVHPLQVNYIHQLIQVRLVENPNALCEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNINVEEYIPGYKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIMPEMQTCLNGDRSKLPQIMTELRYWITHRRCEKTLQHLPATATENLTFLNMPDHPLLQSGRHKIYVKLHRHPNVVLVVHLKEKSSMPNEMEYTFYLGLLVYQSNETEVLSEDLTKQLVPVQTSSSNVENQGSHHHEIPKVFAKLLRLIEFDTFVATHGPGTDVDDVPPHKRKSNSELTAPPTKQAKTIYPAYIIPDLAHVVAMCDEKIPFLNLAQALTKYNVPHCGLQVESNAISLVLKIITLPKPTPPDDRKSQFPAIESNVWDDLMKRVLSISIRSHMNKSNKIRSWVMEFIFYSTPLQSIHPREQGNRRTLYLSYDQISNYSQTVEDLLKDWSKIVYLYTLVYSFAEHIKNKRLNITDMLSINSYNYTNLLLGYGPKKEVLCNIFWSAPAGGFHMTFLGGITAVNAHSVIRDQLAIYLNTKHNLTQIVQLLHETYNPLSSIAKLPIIPHLGIPRPQVPVLSFCILPQSPCVIRLAYQAVYCLEIRFRSGRLISIRDGAYSRFDRNLIEEFTPIQGLKGFLSKYVDENAVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSGINQNTNSGSGSSSQVINRMPPPNRSYAGAVPTLLTHEKFDLLCRPSPHPNKDITSTIDISPLERFLGCVYMRRQLYRNVQNEDTLTALNSNEPGVVLFKVDGLQCQVILNQVHMQSLHLKVNQLPPPHTPDSKQPFQLSPDDLLIIEKFFDTRVAAPPYRPNALHGFSRVLSCAPQVLKDFLQIMRLEMNPDLGGDQIKWTVQFCMRVPPSAAPIVPIGSPGVLMVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQPQSPAATAVSAVLRHFSDHLAQPGQCSLFPAVREILISLQLPNDVPPQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
Length1541
PositionTail
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index53.50
Isoelectric point8.69
Molecular weight172251.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09092
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     180.25|      28|      47|    1087|    1114|       1
---------------------------------------------------------------------------
 1081- 1110 (53.67/22.87)	PNYN..ltSP.....PG.PHMPHPSPGALMPSSPLNPQ
 1131- 1162 (28.76/ 8.27)	DSPF.aamSPantnwPGsPSMPRPSPR...PGQ..SPD
 1163- 1189 (29.39/ 8.64)	HKSG....QS.....SG.INQ.NTNSGSGSSSQVINRM
 1489- 1510 (28.58/ 8.16)	.........P.....PQ.SQAIGPPIGARVGSSP.NPM
 1512- 1539 (39.85/14.77)	HSPMqqmgGP.....VG.P..PQIGPG..YPQMPQNPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.59|      23|     239|    1042|    1064|       2
---------------------------------------------------------------------------
  698-  713 (20.80/ 6.23)	..LPKP.TPPDDRKSQFPA....
 1042- 1064 (48.44/26.49)	LRFPAPHTPPSSSNPHTPASPHP
 1287- 1305 (37.35/18.36)	LHLKVNQLPP....PHTPDSKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.33|      21|      23|     145|     166|       3
---------------------------------------------------------------------------
  145-  166 (35.79/30.78)	TYNRLPTCIRERIVpPDPITPQ
  171-  191 (36.53/24.87)	TLLRLNQVIQHRLV.TGKLMPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.91|      55|     370|     953|    1013|       4
---------------------------------------------------------------------------
  953- 1013 (85.63/72.71)	RDGAYSRFDRNLieEFTPiQGLKGFLS.KYVDENAVYRGRS.....QNEDDNPPS..PIggEdNFGGPG
 1330- 1392 (91.28/55.76)	RPNALHGFSRVL..SCAP.QVLKDFLQiMRLEMNPDLGGDQikwtvQFCMRVPPSaaPI..V.PIGSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.50|      30|     370|      24|      54|       5
---------------------------------------------------------------------------
   24-   54 (48.30/36.94)	SRMNTISL...SVL..IDFTIQRTYHDLTVlAELLP
  391-  425 (42.20/26.98)	SRLSDLKLefqAFLkdVDFNLQGTPAILTV.PVLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.01|      50|     370|     822|     883|       8
---------------------------------------------------------------------------
  822-  883 (74.55/80.67)	SYNYTNLLLGYGPKKEVLCNifwSAPAGGFHMT..........FLGGItavnahsVIRDQLaiYLNTKHNLT
 1195- 1254 (85.46/57.94)	SYAGAVPTLLTHEKFDLLCR...PSPHPNKDITstidisplerFLGCV.......YMRRQL..YRNVQNEDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.48|      23|      23|     237|     259|      13
---------------------------------------------------------------------------
  218-  235 (22.86/ 9.24)	...GDNANV..PWR.LLDIDILVE
  237-  259 (38.02/19.78)	KETGDGKALVHPLQ.VNYIHQLIQ
  261-  284 (33.59/16.71)	RLVENPNALCEVYNcLHYFCQSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.67|      14|      15|     454|     467|      16
---------------------------------------------------------------------------
  454-  467 (28.12/19.29)	P.IMPEMQTCLNGDR
  471-  485 (23.55/14.81)	PqIMTELRYWITHRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.53|      45|     240|     509|     560|      18
---------------------------------------------------------------------------
  509-  560 (73.36/74.07)	HPLLQSGRHKIYVKLHRHPNVVLVVH..LKEKSSMpnemeytFYLGLLVYQSNE
  759-  805 (76.17/57.94)	HPREQGNRRTLYLSYDQISNYSQTVEdlLKDWSKI.......VYLYTLVYSFAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09092 with Med14 domain of Kingdom Metazoa
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