<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09087

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSVNNKVTTIGTGSINPTALLTNMSNAIEKNKQWQRELLMERIRSHSSQHKTFQELSKAMRMGMLEKRYALDAVEKSNLQKCLDSMQHCIKVTSRQGLVERLESLSRQLGLKFMDDTKVLFISTDMFFLEIVLDANGALSDVKVHHECKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAEPKVKTKAFDAMQAVESDLYNLFQMQSFSKDTQQVLKDSIVGIVLKRHGGHPMRLVYFVSPYDLISLESKSLQSLSLDLLHNKQLGFSVTVNLEASSANKLQILPTVSFAKESQSGLEVPVFAPLNQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCGSPTTSQASAADINNSTVLEGQHKATLPMISNIMSLIIYTASEQQLKNSQKGLFVCLPDQTHCYFFTENKLLKSTLVQSIPFTEPSQVPKILDFLKRQALFYALLSSCVRPQSKMVNVDIDSTIILEVNAISYHQISVALQHPYEESMATVEFDLHNGNVQCIIYSLSNNYDLLSLKLTNVVQKCCSIPVTIRALLRYWDQERIKKFQRGIGAAAGSTGANTSNNGSNAVSNNSAYGNFNIAGVSNDPGGGGGGVGGGGGGCMNRGLGGSVKMEQALQQRSQLASTTTGYLKYKCGDIKQEDFHESPKSQTLAMVTDTTVANSMPVREVSSLGQQQQQTTHETLQQQTNTTFTAEREIADKYKNIWKDKTPAIKNCVSITPIGTQHDQIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSINISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKCSTAAAMGSSSSSGLNPGALVRSSTSSTVVAAAAAAAAAMAALKNKDKSTVSPSAVSSAAAAAAAAVVKSSMGVVTPTMQQLKGVTGLNHMAAAAAGFGGNTATVNSLDLNAAMRKGVPSAVSLMTSTAVTATINSTPAQRRATQQVHRHHQQRQIPLQPLGSSEGDTNHTFNKNSSEYMVKSQSQEGLKLTINKTKAISTKKFGVNNDPTCKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLNKNKSLENSIEFLSNDNLRKSVKKSAVSTSSATSTHMSSLSAAPSQSALRIDYHADMIKILQYASPTMAASMEGFMKSFNTKFQIPKLSQRNATKTTTATTTAASVADTSKSGSLCITTSITKACPSSTTGVSDVQTPSLPPTSNASSQQSTMAATETPTIVNANQSLVSLHVLKSSPISSTSPNHMNSLTATKSALNFVDNSNVSNNSMCNESLLATLAGE
Length1417
PositionMiddle
OrganismGlossina palpalis gambiensis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.334
Instability index49.29
Isoelectric point9.41
Molecular weight151137.21
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09087
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     338.32|      58|      58|     936|     993|       1
---------------------------------------------------------------------------
  769-  815 (59.51/24.90)	NSS.....TGI......TITPINTGS..S....SinISGVS.......SK.DKKSSTTSST.............C............ISNLP...SSTTS
  816-  874 (58.76/24.49)	AKRaldvqGEL......PKEKKRKKK..R....D..DSPMG.......PP.EKIYSRQNSP..AGSSEAAAGAVA.................rkfSSPSS
  875-  945 (56.54/23.27)	SPK.....GSSggllasCVT....GS..SlttrP..SPKHS.......P....VYSSPKHN..TASNSPKSPFGThspkhsssgkpsMSTLK...NATVA
  946- 1013 (77.06/34.50)	SPK.....GDK......CSTAAAMGS..S....S..SSGLN.......PG.ALVRSSTSSTVVAAAAAAAAAMAA..lknkdkstvsPSAVS...SAAAA
 1014- 1047 (26.85/ 7.02)	A...................AAAVVK..S....S..MGVVT.......PTmQQLKGVTGLNHMAAAAA................................
 1305- 1375 (59.59/24.94)	SKS.....GSL......CITTSITKAcpS....S..TTGVSdvqtpslPP.TSNASSQQST......MAATETPT..ivnanqslvsLHVLK...SSPIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     270.95|      78|     443|     678|     764|       2
---------------------------------------------------------------------------
  678-  764 (116.29/80.41)	QQQQQtTHETLQQQTNTTftaeREIADKYKNIWKDktPAIKNCV....SITPIGTQHDQIQDVKRTGSIEIIPLtgQQHNSIAGTVN...NGNS
 1080- 1127 (53.73/22.31)	......................................AVTATI....NSTP..AQRRATQQVHRHHQQRQIPL..QPLGSSEGDTNhtfNKNS
 1131- 1200 (100.93/51.07)	MVKSQ.SQEGLKLTINKT....KAISTKKFGVNND..PTCKKLSasekSWSPSQSKH.TFQKSNSSG.............NLAGKLN...KNKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.90|      45|     443|      66|     111|       3
---------------------------------------------------------------------------
   66-  111 (70.59/58.92)	LEKRYALDAVEKSN.LQKCLdSMQHCIKVTSRQGLVERLESLSRQLG
  511-  556 (74.31/56.32)	LSNNYDLLSLKLTNvVQKCC.SIPVTIRALLRYWDQERIKKFQRGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.26|      17|     147|    1057|    1078|       4
---------------------------------------------------------------------------
 1059- 1075 (29.30/12.94)	LDLNAAMRKGVPSAVSL
 1246- 1262 (26.96/ 7.87)	IDYHADMIKILQYASPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.76|      70|     101|     152|     223|       5
---------------------------------------------------------------------------
  152-  223 (110.71/77.66)	EQQSCSEL.VDCLNRGDFA.DFTAQLEGfSSIYQLNAEPKVkTKAFDAMQAVESDLYN.LFQMQSFSKDTQQVLK
  254-  326 (100.06/61.51)	ESKSLQSLsLDLLHNKQLGfSVTVNLEA.SSANKLQILPTV.SFAKESQSGLEVPVFApLNQMNSMLLPATFVLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.76|      17|     145|    1226|    1244|       9
---------------------------------------------------------------------------
 1226- 1244 (24.42/17.65)	SATSTHMSSLSAapSQSAL
 1376- 1392 (31.34/16.11)	STSPNHMNSLTA..TKSAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09087 with Med1 domain of Kingdom Metazoa
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