<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09085

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSVNNKVTTIGTGSINPTTLLTNMSNAIEKNKQWQRELLMERIRSHSSQHKTFQELSKAMRMGMLEKRYALDAVEKSNLQKCLDSMQHCIKVTSRQGLVERLESLSRQLGLKFMDDTKVLFISTDMFFLEIVLDANGALSDVKVHHECKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAEPKVKTKAFDAMQAVESDLYNLFQMQSFSKDTQQVLKDSIVGIVLKRHGGHPMRLVYFVSPYDLISLESKSLQSLSLDLLHNKQVGFSVTVNLEASSANKLQILPTVSFAKESQSGLEVPVFAPLNQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCGSPTTSQSSAADINNSTVLEGQHKATLPMISNIMSLIIYTASEQQLKSSHKGLFVCLPDQTHCYFFTENKLLKSTLVQSIPFTEPSQVPKILDFLKRQALFYALLSSCVRPQSKMVNVDIDSTIILEVNAISYHQISVALQHPYEESMATVEFDLHNGNVQCIIYSLSNNYDLLSLKLTNVVQKCCSIPVTIRALLRYWDQERIKKFQRGIGAAAGSTGANTSSNGSNAVGNNSAYGNFNIAGVSNDPGGGGGGVGGGGGGCMNRGLGGSVKMEQALQQRSQLASTTTGYLKYKCGDIKQEDFHESPKSQTLAMVTDTTVANSMPAREVSSLGQQQQQTTHETLQQQANTTFTAEREIADKYKNIWKDKTPAIKNCVSITPIGTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSMNISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKCSTAAAMGSSSSSGLNPAALVRSSTSNTVVAAAAAAAAMAALKNKDKSTVSPSAVSSAAAAAAAAVVKSSMGVVTPTMQQLKSVTGLNHMAAAAAGFGGNTATVNSLDLNAAMRKGVPSAVSLMTSTAVTATINSTPAQRRATQQVHRHHQQRPIPLQPLGSSEGDNHTFNKNSSEYMVKSQSQEGLKLTINKTKAISTKKFGVNNDPACKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLNKNKSLENSIEFLSNDNLRKSVKKSAVSTSSATSTHMSSLSAAPSQSALRIDYHADMIKILQYASPTMAASMEGFMKSFNTKFQIPKLSQRNATKTTTATTTAASIADTSKSGSLCITTSITKTCPSSTTGVSDVQTPSLPPTSNASSQQQSTMAATETPTIVNANQSLVSLHVLKSSPISSTSPNHMNSLTATKSALNFVDNSNVSNNSMCNESLLATLAGE
Length1416
PositionMiddle
OrganismGlossina pallidipes (Tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.336
Instability index50.48
Isoelectric point9.41
Molecular weight151033.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09085
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     316.84|      98|     105|     764|     867|       1
---------------------------------------------------------------------------
  764-  852 (127.13/62.80)	....................ST..TVSNSSTGITITPIN......TGSS.....SMNIS......................GVSSKDKKSSTTSSTCISNLPSSTTSAKRAldVQGElPKEKKRKKKRDDSPMG..................PPEKIYSRQN
  853-  977 (132.70/62.10)	SPAGSSEAAAGAvarkfsspSS..SPKGSSGGLLASCV.......TGSSlttrpSPKHS......................PVYSSPKHNTASNS...PKSPFGTHSPKHS..SSGK.PSMSTLKNATVASPKGdkcstaaamgsssssglnPAALVRSSTS
 1002- 1093 (57.00/20.48)	SPSAVSSAAAAA..........aaAVVKSSMGV.VTPTMqqlksvTGLN.....HMAAAaagfggntatvnsldlnaamrkGVPS...AVSLMTSTAVTATINSTPAQRRA...................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.99|      17|      19|     717|     733|       2
---------------------------------------------------------------------------
  717-  733 (32.72/27.20)	IK..NCVSITPI.GTQHDPI
  736-  755 (21.27/14.26)	VKrtGSIEIIPLtGQQHNSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.46|      36|     443|      66|     111|       3
---------------------------------------------------------------------------
   70-  109 (50.36/46.88)	YALDAVEKSNlQKCLDSMQhciKVTSRQGLVERLESLSRQ
  182-  217 (62.10/28.36)	YQLNAEPKVK.TKAFDAMQ...AVESDLYNLFQMQSFSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.72|      74|     105|     344|     427|       4
---------------------------------------------------------------------------
  344-  427 (107.97/93.44)	CGSPtTSQSSAADINNSTVLEGQhKATLPMISNIMSLiIYTASEQQLK.SSHKGlfvclpdQTHCYFFT...ENKLLKSTL...VQ...SIPFT
  452-  535 (107.75/65.72)	CVRP.QSKMVNVDIDSTIILEVN.AISYHQISVALQH.PYEESMATVEfDLHNG.......NVQCIIYSlsnNYDLLSLKLtnvVQkccSIPVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.13|      56|      62|    1119|    1176|       5
---------------------------------------------------------------------------
 1119- 1176 (95.55/51.81)	H.......................TFNKnsSEYMVKSQSQ.EGLKLTINKTKAI..............S...TKKFGVNNDPA....C......KKLSASEKSWSPSQS
 1178- 1240 (57.12/25.18)	H.......................TFQK........SNSS.GNLAGKLNKNKSLensieflsndnlrkS...VKKSAVSTSSAtsthM......SSLSA.....APSQS
 1247- 1329 (48.46/20.25)	HadmikilqyasptmaasmegfmkSFN...TKFQIPKLSQrNATKTTTATTTAA..............SiadTSKSG....SL....CittsitKTCPSSTTGVSDVQ.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09085 with Med1 domain of Kingdom Metazoa
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