<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09072

Description Uncharacterized protein
SequenceMAPAPQPLEQALAGYLPQGQEGSSRMNTISLSVLIDFTIQRTYHDLTVLAELLPRKSDMERKIEIYNFSARTRQLFIRLIALVKYANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDPITPQEKKQTLLRLNQVIQHRLVTGKLMPQMREFKIRNGRVIFEVKHEFNVSLTVMGDNANVPWRLLDIDILVEDKETGDGKALVHPLQVNYIHQLIQVRLVENPNALCEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNINVEEYIPGYKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRSDHLSMERMLRCHVPKHLDCPIMPEMQACLNGDRSKLPQIMTELRYWITHRRCEKTLQHLPATATENLTFLNMPDHPLLQSGRHKIYVKLHRHPNVVLVVHLKEKSSMPNEMEYTFYLGLLVYQSNETEVLSEDLTKQLVPVQTSNSNVENQGSHHHEIPKVFAKLLRLIEFDTFVATHGPGTDVDDVPPHKRKSNSELTAPPTKQAKTIYPAYIIPDLAHVVAMCDEKIPFLNLAQALTKYNVPHCGLQVESNAISLVLKIITLPQPTPPDDRKSQFPVIEPNVWDDLMKRVLSISIRSHMNKSNKIRSWVMEFIFYSTPLQSIHPREQGNRRTLYLSYDQISNYSQTVEDLLKDWSKIVYLYTLVYSFAEHIKNKRLNITDMLSINSYNYTNLLLGYGPKKEVLCNIFWSAPVGGFHMTFLGGITAVNAHSVIRDQLAIYLNTKHNLTQIVQLLHETYNPLSSIAKLPIIPHLGIPRPQVPVLSFCILPQSPCVIRLAYQAVYCLEIRFRSGRLISIRDGAYSRFDRNLIEEFTPIQGLKGFLSKYVDENAVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSAINQNTNSGSGNSSQVINRMPPPNRSYAGAVPTLLTHEKFDLLCRPSPHPNKDITSTIDISPLERFLGCVYMRRQLYRNVQNEDTLTALNSNEPGVVLFKVDGLQCQVILNQVHMQSLHLKVNQLPPPHTPDSKQPFQLSPDDLLIIEKFFDTRVAAPPYRPNALHGFSRVLSCAPQVLKDFLQIMRLEMNPDLGGDQIKWTVQFCMRVPPSAAPIVPIGSPGVLMVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQPQSPAATAVSAVLRHFSDHLAQPGQCSLFPAVREILISLQLPNDVPPQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
Length1479
PositionTail
OrganismGlossina pallidipes (Tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.329
Instability index54.34
Isoelectric point8.71
Molecular weight165415.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09072
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     154.27|      23|      23|    1029|    1051|       1
---------------------------------------------------------------------------
  972-  989 (25.37/ 6.51)	..........PQS...PRDS.GLRFPA.PHTP.P
  990- 1016 (26.40/ 7.08)	SS......snPHTpasPHPSAGGGVGTGSSNA.Q
 1019- 1048 (43.80/16.83)	PNYnltsppgPHM...PHPSPGALMPSSPLNP.Q
 1427- 1449 (31.90/10.16)	PPQ.......SQA...IGPPIGARVGSSP.NPmM
 1450- 1464 (26.80/ 7.31)	HS..............PMQQMGG..PVGP..P.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.59|      21|      23|     145|     166|       2
---------------------------------------------------------------------------
  145-  166 (35.60/23.37)	TYNRLPTCIRERIVpPDPITPQ
  171-  191 (34.99/17.82)	TLLRLNQVIQHRLV.TGKLMPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.90|      11|      28|    1234|    1244|       4
---------------------------------------------------------------------------
 1234- 1244 (23.17/ 8.19)	PPHTPDSKQPF
 1265- 1275 (21.73/ 7.26)	PPYRPNALHGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.38|      22|      28|    1128|    1151|       5
---------------------------------------------------------------------------
 1128- 1151 (31.97/26.32)	PPPNRSYAGAVpTLLTHEKFdLLC
 1155- 1176 (41.41/23.31)	PHPNKDITSTI.DISPLERF.LGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.58|      30|      31|     326|     355|       6
---------------------------------------------------------------------------
  326-  355 (52.91/31.92)	KDPK..SELGYRL.......TVQSDPNEIGRPLAVVHVP
  360-  386 (44.16/25.41)	KE.S..AEVADR........AVRSDHLSMERMLR.CHVP
  407-  445 (38.50/21.20)	KLPQimTELRYWIthrrcekTLQHLPATATENLTFLNMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.69|      26|      31|    1057|    1085|       8
---------------------------------------------------------------------------
 1057- 1084 (41.56/29.56)	PGPNTLYMQGHQDSPFAAMSPaNTNwPG
 1091- 1116 (48.14/24.19)	PSPRPGQSPDHKSGQSSAINQ.NTN.SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.80|      21|      31|      57|      77|       9
---------------------------------------------------------------------------
   57-   77 (35.72/26.13)	SDMERKIEIYNFSARTRQLFI
   90-  110 (35.08/25.53)	SKVDKSANIMSFLDKQNMLFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.33|      20|      20|    1363|    1382|      10
---------------------------------------------------------------------------
 1363- 1382 (33.88/21.25)	PMVYDLSSNLTQLAEKREQP
 1385- 1404 (33.45/20.88)	PAATAVSAVLRHFSDHLAQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.44|      22|      27|     233|     259|      13
---------------------------------------------------------------------------
  233-  259 (32.39/34.50)	LVEdketgDGKALVHPLQ.VNYIHQLIQ
  262-  284 (37.05/25.00)	LVE.....NPNALCEVYNcLHYFCQSLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09072 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSAINQNTNSGSGNSSQVINRMPPPNRSYAGAVP
2) PQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
924
1428
1139
1479










Molecular Recognition Features






MoRF SequenceStartStop




NANANA