<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09071

Description Uncharacterized protein
SequenceMLSLLQEKRPLKRSRLGPPDVYPQEAKQREDELTPSNVNKGFASMPPLSDEFGTAHTSNVNASKVASFFNAILAKKEELMTLQDTVRKKQQINFKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTGNLIKFMKELLPKLQEYYHLCEKSSSSEKALLSGQGAPTTQNNNASLTLSHSSNNATLVPSIASPVPMLSPANSQSSSSGGLGVLSSNSGSGVGTSSSQSSITGANQAPVSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRMEFLNWILELLDRMRTQANFDESLKRLVLTFALPYMQDFVQSERLCRKMAYIVAKKLTNLLNAVIDQQQSLTNGKSENTMHMEMDEEIDKKKTQLDPYEVAINEYLNCPHHRDIILYLSTILQVITVECPTAMVWCGIGENRAPAALCGSPLDHLPVAPSVLPMPIKCPITNAEVRRQLRATEAEIVLRSKHAENRWFAEKWQNANKNSYTHVLSILDYLDTHCFDRMDQTNSIDSLYANIFKTFITIRREVGPNGEIKEIRHEYDANVVDGTTVRILCEWAVSSQRWGEHRAIVVALLLDKRQIEVTTPNESDNNNGNAVAHSNNNLNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGGLTNRTQFTNLVHLFSALIRYDVFSHNAYMHTLISRGDLLEGVANVDSSKPSVTATTTVSGPVSNKASSPPGNQGFDDDFGTSMDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDTSNSIGCDNANSSISRHYIYTKHFPIPQDDPTTSYSSESNQRYILLFGVGKERDEKKHAVKKMSKEICKLFTKKFSIDVAEGGKVKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNAFALGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPELENQLQAKKSNMVRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFDGLCRTIKHVTNPSECSSAERCILAYLSDLYESCFLLKSKEQEPEFFQQMAAIKKFKDIFNAPEQLGIVPQAYNPQFLQELFTSPKRGGKVDSIWLHQLHESPSNVYSFVSNAIVAVCHEADNDRLNDIAISCAELTAGCNALSEEWIAALQSICNAMKKPRYPHFCQVDIQNSKIHNSLAVFICILVARHCFSLADFVMNFALPTLANAYPVGGEISADAEAGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLTAVGSSSNIKLSCDRHLLIGAHKNVPLEAVLAVLKAILIVVDTTALKTSNMSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLSQILGTSDLNSLNTEHDHDMTQQLTSTPSNTGALNNSEQISLLEFAQHVLKQICAQEHVLERCLKNAEKLCDMIIDEMLTPKQVQRILHMICYPESEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHRQSMNNPVELSSWLDTVARAAIDVFLMEEVVVGSGLKSEHRPKASTWLVAPLVAKLTPAVQGRILRVAGQVLESMSYFSKVSKSDNNSSCSGDEREKSNSCGSASSSYSIGVNGSNSRSRKMPLNYQPFLGLILTCLKSQDEYKEGLLCSLYSQLSQCLQSYTEFDTMGGVDDPLGREEMLDALQLRFSLVGGMFESIQKNGTSITDWAILLAQLVCQGVVDLSTNKELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEALPLPPEDIEPIAEKIVKDEMKADTPSSVDQSPSAVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTSHNPQQQQWPGQNQFHPMQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQSLGAQNPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNASIMASQNNTGLVSASAMMQQNVGVGGGAVGQNMVNQNAGQFQNFSQYQHQAINQSGNTNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGSVPPYSRQQTSGGKPGVVSTQQQFQQQQRLQHQMMQMQGIGPQNNGASSMTQPQNQTVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
Length2379
PositionKinase
OrganismGlossina pallidipes (Tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.451
Instability index48.45
Isoelectric point6.50
Molecular weight264298.13
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09071
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     129.40|      18|      19|    2140|    2157|       1
---------------------------------------------------------------------------
 1948- 1962 (20.59/ 6.15)	QNPnaIIQQQ.....QQM.P.G
 1964- 1978 (22.47/ 7.54)	PSG..I.QQQMNV..G..NSQQ
 2019- 2036 (25.57/ 9.82)	QQQ..FYQQQQQG..MQMNRFE
 2055- 2074 (24.52/ 9.05)	RQP..PMNQNNSAafNTMQQQQ
 2140- 2157 (36.26/17.70)	QNP..IMQQQISA..QTMNPQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     142.26|      17|      19|    2161|    2177|       2
---------------------------------------------------------------------------
 1989- 2007 (23.93/ 8.35)	GPQG.MAQTSHNpqQQ...QWPG
 2165- 2184 (21.82/ 6.91)	QNAG.VMSTGNN..QNasiMASQ
 2198- 2213 (21.54/ 6.72)	QNVG.VGGGAVG..QN...MV.N
 2214- 2231 (22.36/ 7.28)	QNAGqFQNFSQY..QH...QAIN
 2329- 2345 (24.68/ 8.86)	QNNG.ASSMTQP..QN...QTVG
 2364- 2378 (27.93/11.07)	QPN..MMGQ.QY..QH...QPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.70|      15|      19|    1108|    1126|       3
---------------------------------------------------------------------------
 1108- 1126 (21.87/24.51)	GIVPQAYnpqfLQELFTSP
 1130- 1144 (27.83/16.70)	GKVDSIW....LHQLHESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.23|      56|     247|    1374|    1431|       5
---------------------------------------------------------------------------
 1374- 1431 (85.94/54.91)	GSTPKSNERPVDLSQILGTSdLNSLNTEhDHDMTQQLTSTPSNTGALN..NSEQISLLEF
 1633- 1684 (90.95/49.69)	GSNSRSRKMPLNYQPFLGLI.LTCLKSQ.DEYKEGLLCSLYSQ...LS..QCLQ.SYTEF
 2077- 2102 (24.35/ 7.20)	.................................TQGLT.TQSQTGVLNpvQQQQLQQQQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.17|      21|      24|     258|     278|       6
---------------------------------------------------------------------------
  258-  278 (37.19/22.28)	SQSSSSGG.LGVLSSNSGSGVG
  282-  303 (32.98/18.81)	SQSSITGAnQAPVSGSSISGIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.04|      17|      18|    2253|    2269|       8
---------------------------------------------------------------------------
 2253- 2269 (33.27/15.26)	QQPPQR.....GPAGMTSNRGQ
 2273- 2285 (22.99/ 8.33)	QAP.........NVTMNSTMGQ
 2288- 2309 (22.78/ 8.18)	VPPYSRqqtsgGKPGVVSTQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.62|      10|      18|     743|     752|       9
---------------------------------------------------------------------------
  743-  752 (18.67/ 9.71)	G.VANVDSSKP
  762-  772 (14.95/ 6.23)	GpVSNKASSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.07|      10|      18|    1340|    1349|      10
---------------------------------------------------------------------------
 1340- 1349 (17.39/10.50)	TTALKTSNMS
 1359- 1368 (18.69/11.91)	TTGGKRSGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.25|      15|      24|    1460|    1474|      12
---------------------------------------------------------------------------
 1460- 1474 (25.68/20.69)	IIDEMLTPKQVQRIL
 1486- 1500 (24.56/19.37)	IISELDQRSMIVRIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.84|      32|     249|     218|     255|      13
---------------------------------------------------------------------------
  218-  255 (46.49/33.28)	GQGapttqNNNASLTLSHSS.NNATLVPSIAsPVPMLSP
  471-  503 (57.35/27.07)	GIG.....ENRAPAALCGSPlDHLPVAPSVL.PMPIKCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.24|      19|      19|     315|     333|      19
---------------------------------------------------------------------------
  315-  333 (35.98/28.49)	YWNYCTQLSKYMHEESLLD
  337-  355 (33.26/25.64)	FLNWILELLDRMRTQANFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.76|      15|      15|    1761|    1775|      22
---------------------------------------------------------------------------
 1761- 1775 (25.06/15.73)	HSTLVSDGQSERDEK
 1777- 1791 (24.71/15.40)	YSNLMKKLKKEIGEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09071 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEPIAEKIVKDEMKADTPSSVDQSPSAVVNMQQFNSNQMMQQNPNAIIQQQQQMPGVPSGIQQQMNVGNSQQSSQMGFMGSNGPQGMAQTSHNPQQQQWPGQNQFHPMQQQQQQQFYQQQQQGMQMNRFERPPHMSNSRQAIHNMLRHRQPPMNQNNSAAFNTMQQQQRQTQGLTTQSQTGVLNPVQQQQLQQQQFARSGMRSMAPSQLTGAAPNQMAPGINTVGMGSQSLGAQNPIMQQQISAQTMNPQNNNQMIMNQNAGVMSTGNNQNASIMASQNNTGLVSASAM
2) KPSVTATTTVSGPVSNKASSPPGNQGFDDDFG
3) KRSRLGPPDVYPQEAKQREDELTPSNVNKGF
4) MSGNSSGGAFGTTGGKRSGFSTPVHPGSTPKSNERPVDLS
5) VGVGGGAVGQNMVNQNAGQFQNFSQYQHQAINQSGNTNQQANIVANFMAQQQQQQPPQRGPAGMTSNRGQYMSQAPNVTMNSTMGQGSVPPYSRQQTSGGKPGVVSTQQQFQQQQRLQHQMMQMQGIGPQNNGASSMTQPQNQTVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
1907
751
12
1348
2200
2195
782
42
1387
2379










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRSRL
2) RYILLF
11
866
16
871