<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09069

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQSHQTNGASLEDCHTNFFALTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRIQSTKQDNSDLNALGDEVNNTKVHPPLSLAAAKELWIFWYGEEPDLTDLVDAELLRVAANQATWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQDQTSPNNSPIVAEAAGENSAASANGSNMPKPRKVILAPFGMAATLTGNSYKANDPMAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNTGDNLSSNVRKPLTETVSNKLTTNTNQTASSKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANTAIPANFNENISVIGNGGSNGGSGGGASIGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTKSLAAQHHHPAAATTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPASVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGMHNIIGGAGSGGGGGAGGGGVVGVAVGGPNLNENVQSSGIGGGSGGGTNQPASVGRCTPTIQQQQSSSQQHQQQQQPQQQQQQQHQQQQLQQQHSHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASAGDVKLESSGLQLNPTVSSASSTSHSHSTTTLNAMLPNSLKRNSSTQGSAGNSIHAMHDFLNLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSYHTIKRFKPNDLSKPCRIMRTKNLYEGHTHIKPLMPSPRSVYGNQLLAADSVQAAQMASASGADSSTVLADMSGGLVGIASNNQNISRLANDNSAGPLTAVGSSTTSNFFEELDIKTEMMSGTASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAISNTAIDDLKRSTNPAILANSNVAIANSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGPNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSKYAPLTNLPSQTMAPLIAPPNCIYKPSWQPTRSTHQQPQQQQQLQQHNQSLQQQQNHQQQQPQHQQHQQLHELLSSAPRTPLQQPRTPLGPMSSSPMHNTVPTPLSSGGGGGGSLLLNQLNCPQAALTNTPSAMQQLMQRAGMSPVSPAPHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPSASLGLFSGTVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGVYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFTSKSNGTNGNGVMDKAADQLAFSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTTIANVLEYMDANDIISLALEQARLAFDSSRVDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYMPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTLMCGWGGMLTVSQRPPTEKPYTTNMDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPNDKSLLNPPDANIHAGSHNNTRLNASGNTSSPMAGTITGLENTDRGDHASSTPMEHGDLSQHATTDTSGNINDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPESVRANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDDQNRRPYKMYTPPYILAPIHEKNEKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVLGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPSWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2662
PositionMiddle
OrganismGlossina pallidipes (Tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.422
Instability index51.83
Isoelectric point6.01
Molecular weight287991.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09069
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     132.49|      15|      16|     748|     762|       1
---------------------------------------------------------------------------
  738-  755 (28.17/11.72)	PTIQQQQsssQQHQQ.........QQQ
  756-  772 (28.44/11.90)	PQQQQQQ.qhQQQQL.........QQQ
 1289- 1298 (23.62/ 8.74)	P...QQQ...QQ..L.........QQH
 1299- 1312 (28.11/11.68)	NQSLQQQ...QNHQ..........QQQ
 1313- 1336 (24.16/ 9.09)	PQHQQHQ...QLHELlssaprtplQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.52|      19|      21|    1390|    1410|       2
---------------------------------------------------------------------------
  589-  602 (23.61/ 6.58)	...G.SPGTPAPS.....PHPNS
 1390- 1410 (32.50/20.11)	QRaGMSPVSPAPHvPF..PHTSP
 1416- 1434 (28.41/ 9.90)	QR..QTPIHPPP..PYevAVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     480.51|     151|     489|    1865|    2149|       3
---------------------------------------------------------------------------
  296-  456 (234.15/92.11)	DPMAEKIL...EDWASFFPLCNKENSDVppVVEVISgghkmYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLsSVNTGDNLSSNVR....KPLTETVSNKLTTNTNQTASSKSLAY.......MVERLKIDP..KKVQNHYDALTSNYTCNTTNTHAppQAATEMP
 1883- 2049 (246.37/285.80)	QPIPSVIVghdKDWISVAPLAIHYWDKF..LLEPYS.....YARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTL.MCGWGGMLTVSQRppteKPYTTNMDNWLRTMEDTTLAEKLRLYahafqhmLVPYLNRIPndKSLLNPPDANIHAGSHNNTRLNA..SGNTSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.80|      17|      28|     689|     706|       4
---------------------------------------------------------------------------
  689-  705 (31.26/11.22)	SGGGGGAGGGGVVGVAV
  717-  733 (35.24/13.41)	SGIGGGSGGGTNQPASV
 1588- 1604 (32.30/11.97)	SGGGGGIGSALDSPASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.66|      20|      21|     964|     984|       5
---------------------------------------------------------------------------
  964-  984 (30.33/22.47)	AsASGADSSTVLA.DMSGG.L..VG
  985- 1008 (21.33/ 9.67)	I.ASNNQNISRLAnDNSAGpLtaVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.44|      23|     495|    2127|    2149|       8
---------------------------------------------------------------------------
 2127- 2149 (42.88/25.47)	YVVEPFTYGS....DSPELERLACIAI
 2620- 2646 (37.56/21.31)	YVLEGYNALSwlalDSNTHDRLSCLPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.90|      26|     495|      10|      40|       9
---------------------------------------------------------------------------
   10-   40 (38.92/43.25)	GASLEDC........HTNFFALTDLCGIkWrKFVNserP
  500-  533 (43.98/28.56)	GASIGDCggeqqadiKPNTLALLQKQQI.W.DFVD...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.00|      19|      21|     804|     823|      10
---------------------------------------------------------------------------
  803-  822 (24.31/16.65)	ANvVASAGDVKLESSGLQLN
  823-  841 (29.69/16.22)	PT.VSSASSTSHSHSTTTLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.54|      22|      34|    1223|    1244|      14
---------------------------------------------------------------------------
 1223- 1244 (42.70/26.03)	ELGSPIEEP.IEDWSYVYRPPQQ
 1258- 1280 (39.84/23.70)	NLPSQTMAPlIAPPNCIYKPSWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      14|      26|     226|     241|      15
---------------------------------------------------------------------------
  226-  241 (18.65/17.56)	EAAAafTTVAASSNNS
  255-  268 (24.30/14.67)	EAAG..ENSAASANGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.48|      13|      24|     907|     919|      16
---------------------------------------------------------------------------
  907-  919 (25.77/15.57)	Y..HT.IKRFKPNDLS
  931-  946 (17.71/ 8.02)	YegHThIKPLMPSPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.94|      40|    1432|     635|     675|      22
---------------------------------------------------------------------------
  635-  675 (73.30/45.43)	TPIEH.LLDKNTPAPTPTDQNDNKSTTASPYVHPtPSVEPPP
 2069- 2109 (70.64/39.46)	TPMEHgDLSQHATTDTSGNINDNKGTDVKPDVKP.PLVLGDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.78|      17|      21|    1012|    1032|      23
---------------------------------------------------------------------------
 1005- 1028 (19.08/22.50)	TAvgsSTTSNFFEELDIKtemmSG
 1029- 1045 (31.69/21.70)	TA...SGTSSISPCKDSK....SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.46|      15|     488|    1347|    1361|      24
---------------------------------------------------------------------------
  552-  569 (22.57/ 9.07)	PAAATTPghgTPLQGANG
 1347- 1361 (29.89/14.57)	PMHNTVP...TPLSSGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.36|      21|      21|     864|     884|      25
---------------------------------------------------------------------------
  864-  884 (39.08/25.72)	AMHDFLNLYKPPKICVKDIDS
  886-  906 (38.28/25.04)	ANDDCLKLDVLYDFTVQDAWS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09069 with Med13 domain of Kingdom Metazoa
Unable to open file!