<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09058

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDDWQSQQFRQSAIAKIKDLLQASGQHLDKNANVMENHIFKKSKSKEEYMTLLTKIYSHFKENSRKLTNEISQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGVPGQQQGNVVGGPSTQQQMMNQMVGPGGLQMNIMGGPGGPQQSQMVGNAQQMTAGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQAGPGGNITAGPTGGAAQGMQGLPGNLQQNQGAGTVSQMHSGNVSGGPQVPSSAMGNNAGQGNLNQMLNMPPGMQKNPNMPLAQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLTVQQQQQQQQLQQVVNNQQQLQQQQQQQANQTGGPQSNQTLPNAQMIPSPALVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKYKQLTKYIEPLKRMVAKFSNDGAQIEGQTKMRKLLEILSNPSQRVSLETLLKCEKVLEKMEIGNIVQQFGKSPNPLMEVITNTLQSPIANHTLYRTFRPTLELLLGTDISAPPPLKKSKTINSNETEIPHLLQGELARLDTKFKVSLDTTVQNNTKSIKLICCLDDKKLPSVPPININIPEEYPLSSPDCILIEQDYSCTSFLKSVQSAFIARIAKLPKIYSLSHLLNTWEMSVRQACSPNTSKPICELTALFGM
Length762
PositionTail
OrganismGlossina pallidipes (Tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.03
Grand average of hydropathy-0.648
Instability index58.90
Isoelectric point9.46
Molecular weight82595.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09058
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     564.88|      72|      72|     212|     283|       1
---------------------------------------------------------------------------
   66-  119 (60.35/13.03)	RKLTNEISQQ.N....M....MQD.PLNALQN.LASQGN...R..NpQMMS.MG.GGP...........GGPvtasN...LLQS........................LN.
  120-  178 (68.18/15.87)	QQRPGQ...Q.Q....M....QQMqG...........MR.pqM....PMGGvPGQ..Q......QGNVVGGP....StQQQMM..........NQMvgPGGlQMNIMGG..
  179-  255 (113.08/32.22)	...PGG.PQQsQ....MvgnaQQM.TAGGSGPgVGQGLGpgqM..N.QMVG.PGSGGP......MGSGAGGP....N.QMQMQAA.......AGQM..QGG.PMNVHGMNV
  256-  309 (86.38/22.50)	QQLPGQMPQQ.Q....M....QQM.SMQQHSQ.LNQMMN.arM..N.Q.AG.PG..GN......ITAGPTGG...........AA.......QG.M..QG...........
  310-  361 (55.05/11.09)	..LPGNLQQN.QgagtV....SQM.....HSG......N...V...........SGGPqvpssaMGNNAGQG....N...............LNQM..LNM.P...PGM..
  362-  422 (90.32/23.94)	QKNP.NMPLA.Q....N....NQM.FNVNRGV.VGQQQF...L..R.QSPS.PST.........VSSPAGGL....T..VQQQQQ.......QQQL..Q....QVV...NN
  423-  503 (91.51/24.37)	QQ...QLQQQ.Q....Q....QQA.NQTGGPQ.SNQTLPnaqMipS.PALV.PTSSPQ......MSGLMQNP....N.QRQMRQSpssnlntPGQV..ANS.PFNPHEEQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     179.36|      45|      45|     513|     557|       2
---------------------------------------------------------------------------
  513-  551 (57.22/34.56)	.......KY.IEPLKRM.....VAKF..SNDGAQIEGQTKMRKLLEILSN...PSQR
  552-  593 (41.94/23.26)	VSLETLlKC.EKVLEKMeigniVQQF..GKSPNP.........LMEVITN...TLQS
  595-  634 (45.84/26.14)	IANHTLyRT.FRPTLEL.....LL.......GTDISAPPPLKKSKTINSN...ETE.
  635-  678 (34.36/17.65)	..IPHL...lQGELARL.....DTKFkvSLD.TTVQNNTKSIKLICCLDDkklPS..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09058 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NSRKLTNEISQQNMMQDPLNALQNLASQGNRNPQMMSMGGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQMPMGGVPGQQQGNVVGGPSTQQQMMNQMVGPGGLQMNIMGGPGGPQQSQMVGNAQQMTAGGSGPGVGQGLGPGQMNQMVGPGSGGPMGSGAGGPNQMQMQAAAGQMQGGPMNVHGMNVQQLPGQMPQQQMQQMSMQQHSQLNQMMNARMNQAGPGGNITAGPTGGAAQGMQGLPGNLQQNQGAGTVSQMHSGNVSGGPQVPSSAMGNNAGQGNLNQMLNMPPGMQKNPNMPLAQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLTVQQQQQQQQLQQVVNNQQQLQQQQQQQANQTGGPQSNQTLPNAQMIPSPALVPTSSPQMSGLMQNPNQRQMRQSPSSNLNTPGQVANSPFNPHEEQLYREKY
64
508










Molecular Recognition Features






MoRF SequenceStartStop




NANANA