<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09054

Description Uncharacterized protein
SequenceMAPAPQPLEQALAGYLPQGQEGSSRMNTISLSVLIDFTIQRTYHDLTVLAELLPRKSDMERKIEIYNFSARTRQLFIRLIALVKYANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDPITPQEKKQTLLRLNQVIQHRLVTGKLMPQMREFKIRNGRVIFEVKHEFNVSLTVMGDNANVPWRLLDIDILVEDKETGDGKALVHPLQVNYIHQLIQVRLVENPNALCEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNINVEEYIPGYKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIMPEMQTCLNGDRSKLPQIMTELRYWITHRRCEKTLQHLPATATENLTFLNMPDHPLLQSGRHKIYVKLHRHPNVVLVVHLKEKSSMPNEMEYTFYLGLLVYQSNETEVLSEDLTKQLVPVQTSSSNVENQGSHHHEIPKVFAKLLRLIEFDTFVATHGPGTDVDDVPPHKRKSNSELTAPPTKQAKTIYPAYIIPDLAHVVAMCDEKIPFLNLAQALTKYNVPHCGLQVESNAISLVLKIITLPKPTPPDDRKSQFPAIESNVWDDLMKRVLSISIRSHMNKSNKIRSWVMEFIFYSTPLQSIHPREQGNRRTLYLSYDQISNYSQTVEDLLKDWSKIVYLYTLVYSFAEHIKNKRLNITDMLSINSYNYTNLLLGYGPKKEVLCNIFWSAPAGGFHMTFLGGITAVNAHSVIRDQLAIYLNTKHNLTQIVQLLHETYNPLSSIAKLPIIPHLGIPRPQVPVLSFCILPQSPCVIRLAYQAVYCLEIRFRSGRLISIRDGAYSRFDRNLIEEFTPIQGLKGFLSKYVDENAVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSGINQNTNSGSGSSSQVINRMPPPNRSYAGAVPTLLTHEKFDLLCRPSPHPNKDITSTIDISPLERFLGCVYMRRQLYRNVQNEDTLTALNSNEPGVVLFKVDGLQCQVILNQVHMQSLHLKVNQLPPPHTPDSKQPFQLSPDDLLIIEKFFDTRVAAPPYRPNALHGFSRVLSCAPQVLKDFLQIMRLEMNPDLGGDQIKWTVQFCMRVPPSAAPIVPIGSPGVLMVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQPQSPAATAVSAVLRHFSDHLAQPGQCSLFPAVREILISLQLPNDVPPQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
Length1541
PositionTail
OrganismGlossina fuscipes fuscipes (Riverine tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index53.50
Isoelectric point8.69
Molecular weight172251.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09054
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     180.25|      28|      47|    1087|    1114|       1
---------------------------------------------------------------------------
 1081- 1110 (53.67/17.71)	PNYN..ltSP.....PG.PHMPHPSPGALMPSSPLNPQ
 1131- 1162 (28.76/ 6.45)	DSPF.aamSPantnwPGsPSMPRPSPR...PGQ..SPD
 1163- 1189 (29.39/ 6.74)	HKSG....QS.....SG.INQ.NTNSGSGSSSQVINRM
 1489- 1510 (28.58/ 6.37)	.........P.....PQ.SQAIGPPIGARVGSSP.NPM
 1512- 1539 (39.85/11.47)	HSPMqqmgGP.....VG.P..PQIGPG..YPQMPQNPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.58|      19|     239|    1042|    1064|       2
---------------------------------------------------------------------------
 1042- 1064 (37.23/22.87)	LRFPAPHTPPsssnPHTPASPHP
 1287- 1305 (37.35/15.77)	LHLKVNQLPP....PHTPDSKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.91|      55|     377|     953|    1013|       3
---------------------------------------------------------------------------
  953- 1013 (85.63/79.12)	RDGAYSRFDRNLieEFTPiQGLKGFLS.KYVDENAVYRGRS.....QNEDDNPPS..PIggEdNFGGPG
 1330- 1392 (91.28/60.68)	RPNALHGFSRVL..SCAP.QVLKDFLQiMRLEMNPDLGGDQikwtvQFCMRVPPSaaPI..V.PIGSPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.50|      30|     370|      24|      54|       4
---------------------------------------------------------------------------
   24-   54 (48.30/32.93)	SRMNTISL...SVL..IDFTIQRTYHDLTVlAELLP
  391-  425 (42.20/24.01)	SRLSDLKLefqAFLkdVDFNLQGTPAILTV.PVLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.33|      21|      23|     145|     166|       5
---------------------------------------------------------------------------
  145-  166 (35.79/25.72)	TYNRLPTCIRERIVpPDPITPQ
  171-  191 (36.53/20.78)	TLLRLNQVIQHRLV.TGKLMPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.45|      73|     239|     466|     560|       6
---------------------------------------------------------------------------
  466-  541 (113.69/80.76)	DRSKLPQIMTELRYWITH.......RR...CeKTLQHLPATATeNLTFL....................NmPDHPLLQSGR..HKIYVKLHRHPNVVLVVHLK.EKSSM
  810-  915 (92.76/67.18)	KRLNITDMLSINSYNYTNlllgygpKKevlC.NIFWSAPAGGF.HMTFLggitavnahsvirdqlaiylN.TKHNLTQIVQllHETYNPLSSIAKLPIIPHLGiPRPQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.60|      53|     346|     307|     389|       7
---------------------------------------------------------------------------
  328-  389 (73.41/112.79)	PKSELgyrltvQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRS...DHLsMERLIvhTVYIRS
  678-  733 (86.19/51.66)	PHCGL......QVESNAISLVLKIITLPKPTPPDDRKSQFPAIESnvwDDL.MKRVL..SISIRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.38|      22|      24|    1190|    1213|      13
---------------------------------------------------------------------------
 1190- 1213 (31.97/29.08)	PPPNRSYAGAVpTLLTHEKFdLLC
 1217- 1238 (41.41/25.76)	PHPNKDITSTI.DISPLERF.LGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.03|      23|      23|     237|     259|      19
---------------------------------------------------------------------------
  237-  259 (38.14/23.14)	KETGDGKALVHPLQ.VNYIHQLIQ
  261-  284 (34.89/20.49)	RLVENPNALCEVYNcLHYFCQSLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09054 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSGINQNTNSGSGSSSQVINRMPPPNRSYAGAVP
2) PQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
986
1490
1201
1541










Molecular Recognition Features






MoRF SequenceStartStop




NANANA