<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09051
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MNFTNSVSVSVETTCESQIQEIQYDGTEIYQPPPTLSETLAKCAAKIDFSKTSLDDLKKEEKITAEECDKDTALFQPSLWPWDSVRNKLNDALTEICVLADVLSIAKDKRYLVLDPVPEEQEETKAIVQVYSRKKALGQAAQILLSGAERLRNSHTEQRNRNVADFHIELLRLRQNWRLKKVGNSIIGDLSYRTAGSKFGMSGTFEVTKAEETVDEEPSTSLSALTGSGNNNGLLNPSPKNSSALRVIVPAELQGVAYFKVITQKDQEDLCTATVNLIGHGPNITQQGYGVWQKTIEDAQNVLFCKELFSQLAREAIQLQAPIPHVVVSNQIRATLLPGIQLIISLCHSTTIDNSQPTPINDHDHDHVLEHSLHQLLREVHHKNSHHPFPHPASGPLGPSKKRMLAGPLAADRQTVLDMTKTQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNGMSKPTMSCVKINIVTHGYDTIYRTSLMIHVHERSLKVICRDGRVMYLSYEPQELRDLILCQINSHQISCLINLARCMAWPVISNSNHLGIGKVEPLGNASSCLLASPNSDRMIAVQIRCTQSQMDIKVYIARSPRHDFFPSPLVPEKFWENLGGHFKEVRFDKIEGKSFLNKIEFLMASLNSNNAS |
Length | 650 |
Position | Head |
Organism | Glossina fuscipes fuscipes (Riverine tsetse fly) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea>
Glossinidae> Glossina.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.325 |
Instability index | 44.81 |
Isoelectric point | 6.78 |
Molecular weight | 72882.42 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP09051
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.78| 26| 63| 298| 325| 2
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298- 325 (39.78/31.81) DAQNVLfcKELFSQLAREAIQLQA..PIPH
364- 391 (44.99/27.87) DHDHVL..EHSLHQLLREVHHKNShhPFPH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.93| 17| 157| 396| 413| 3
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396- 413 (27.89/20.23) PLGPSKKRMLAGPlAADR
559- 575 (32.04/18.81) PLGNASSCLLASP.NSDR
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