<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09035

Description Mediator of RNA polymerase II transcription subunit 13
SequenceTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRIQSTKQDNSDLNALGDEVNNTKVHPPLSLAAAKELWIFWYGEEPDLTDLVDAELLRVAANQATWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQEQTSPNNSPIVAEATGENSAANANGSNMPKPRKVILAPFGMAATLTGNSYKANDPMAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNTGDNLSSNVRKPLTETVSNKLTTTTTTTTTTPTPTPTNTNQTASSKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANTAISANFNENISVIGNGGSNGGSGSVGVGGGGGGGNASIGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTNKGFVGFLKGKFDGKETKREGGGNAKKKGSFKLSMNNLCETMSRQLHDGGRQSVKIPFHCNTTIKPYYAFGFTSNGSNSSSSSSSNSNSNSSSVGNSLAHHVLAQLSSNSHIHINNQQLSIASGSSIGHNNQSCIPSTEMSKVCTKTNTLLRIHRIPPFHKRHLFESDGKDYWLIGNNSTNSKITISSSCFIDSNQKQQQTNYPRAALYQNSACTSEITRKQRSLAAQHHHPAAATTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPASVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNIIGGTGGGGGGGGGGGGGAGGVAGGPNLNENMQSSGIVGGTNQPASVGRCTPTIQQQQSSSQQQHQQQQPQQQQQQQPQQQQQQQQQQQQQQQQHQQQQQPQQQQHSHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASAGDVKLESTGLQLNPTVSSASSTSHSHSHSHSTTTLNAMLPNSLKRNSSTQGSAGNSIHAMHDFLNLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSYHTIKRFKPNDLSKPCRIMRTKNLYEGHTHIKPLMPSPRSVYGNQLLAADSVQAAQIASVSGVDSSTFMADMSGGLVGIASNNQNISRLANDNSAGPLTAVGSSTTSNFFEELDIKTEMMSGTASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAISNTAIDDLKRSTNPAILGNSNVAIANSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVSNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGSNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSNSGGGGGGSLLLNQLNCPQAALTNTPSAMQQLMQRAGMSPVSPAPHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPSASLGLFSGTVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGVYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFTSKSNGTNGNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTTIANVLEYMDANDIISLALEQARLAFDSSRVDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYMPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTLMCGWGGMLTVSQRPPTEKPYTTNMDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPSDKSLLNPPDANIHAGSHNNTRLNATGNTSSPMAGTITGLENSDRGDHASSTPMEHGDLSQHATTDTSGNINDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPDSVRANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDDQNRRPYKMYTPPYILAPIHEKNEKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVLGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPSWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2799
PositionKinase
OrganismGlossina fuscipes fuscipes (Riverine tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.446
Instability index51.08
Isoelectric point6.26
Molecular weight302602.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.39|      25|      28|     967|     992|       1
---------------------------------------------------------------------------
  947-  969 (34.15/14.72)	..NQPASVGRCTPTIQQQQSSSQQQ
  971-  995 (52.62/28.90)	QQQQPQQQQQQQPQQQQQQQQQQQQ
  996- 1017 (38.62/15.04)	QQQQHQQQQQPQQQQHSHQQQQ...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.48|      36|      38|     803|     838|       2
---------------------------------------------------------------------------
  797-  832 (67.08/39.99)	YSRNSVMDTMPVPSVGSPGTPAPSP...............HPNSTLSQPTS
  833-  858 (41.44/20.73)	VPPADQLLAM..........SPRAP...............ASVSNLQQPPT
  859-  899 (29.97/12.12)	..........PIEHLLDKNTPAPTPtdqndnksttaspyvHPTPSVEPPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     278.21|      54|     421|     479|     535|       3
---------------------------------------------------------------------------
  479-  532 (99.61/43.51)	IGN..GGSNGGSGSVGVGGGGGGGN....A..........SIGDCGGEQQADIKPNTLALLQKQQIWDFV
  903-  945 (34.56/ 8.58)	IHNiiGGTGGGGGGGGGGGGGAGGV....AggpnlnenmqSSGIVGG.......................
 1442- 1490 (79.00/32.44)	ITN..LGSNLDS...GLGMLKIKQE....Y..........SI.ELGSPIEEPIEDWSYVYRPPQQA.KFV
 1718- 1769 (65.05/27.10)	.......SAFGAVSSG.GGGGIGSAldspA..........SLAGAGSSSSTTPSTTTPASNGQQHITGYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     231.63|      39|      39|     618|     656|       4
---------------------------------------------------------------------------
  618-  656 (62.17/32.54)	NGSNSSSSSSS......NSNSNSSSVGNSLAHHVLAQLSSNSHIH
  659-  697 (60.97/31.74)	NQQLSIASGSS......IGHNNQSCIPSTEMSKVCTKTNTLLRIH
 1060- 1089 (49.69/24.28)	NPTVSSASSTS......HSHSHS.........HSTTTLNAMLPNS
 1376- 1420 (58.80/30.30)	NCNNSSASSTSavsslnNSVSNISGGANIIQAEDLTKMFPTPPSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.45|      18|      21|    1313|    1331|       5
---------------------------------------------------------------------------
 1313- 1331 (31.60/25.01)	SNDeC..SSVQIHTPPDSNNP
 1332- 1351 (28.85/16.99)	SNG.CaiSNTAIDDLKRSTNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     278.43|      74|     932|    1227|    1303|       6
---------------------------------------------------------------------------
 1227- 1303 (117.57/83.04)	IASNNQNISRL.ANDNSAGPLtaVGSSTTSNFFEELDIKTEMMSGTASGTSSISpCKDSKSGIGGNLFTVEGLNPS..P......N
 2072- 2121 (51.24/25.83)	..........................SKTKTYFKELSTTYEM...CKLGKHTLM.C.....GWGG.MLTVSQRPPTekPyttnmdN
 2167- 2236 (109.62/67.05)	IHAGSHNNTRLnATGNTSSPM..AGTITG...LENSD.RGDHASSTPMEHGDLS..QHATTDTSGNINDNKGTDVK..P......D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.62|      47|     138|     202|     250|       7
---------------------------------------------------------------------------
  202-  250 (75.25/38.66)	SEAAAAFTTVaaSSNNSQEQTSPN.NSPIVAEATGENSAANANGSNMPKP
  343-  390 (71.36/32.18)	SAEAAALTTL..SSVNTGDNLSSNvRKPLTETVSNKLTTTTTTTTTTPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.53|      28|    2304|     411|     447|       8
---------------------------------------------------------------------------
  411-  447 (38.19/42.57)	LKIDPKKVQNHYDALtsnytcNTTNTHAppqAATEMP
 2718- 2745 (50.34/27.89)	LHLHVPNIQTTDDIL......NSTNAHS...SATDHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.27|      47|    2304|      34|      80|       9
---------------------------------------------------------------------------
   34-   80 (82.66/48.39)	RCMQADILCVWRRIQSTKQDNSDLNALGDEVN...........NTKVH....PPLSLAAAKE
 2332- 2393 (71.61/40.90)	KCLALNIFSQCRRHMVHAQAVKSLTGFGTAANieaflkskddqNRRPYkmytPPYILAPIHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.46|      15|      21|    1533|    1547|      10
---------------------------------------------------------------------------
 1533- 1547 (31.17/15.93)	PVSPAPHVPFPHTSP
 1557- 1571 (30.29/15.24)	PIHPPPPYEVAVASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.36|      28|      31|    1654|    1684|      11
---------------------------------------------------------------------------
 1654- 1684 (43.05/32.73)	DTALNV.FRDHNFDSSTVcvcNADSQRIGNIR
 1687- 1715 (44.31/24.15)	DSGVYVpLPGTSFNPSPL...TSSATTVGNIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.79|      50|     582|     537|     609|      12
---------------------------------------------------------------------------
  537-  609 (68.97/92.09)	KAPCICTnKGFVGFLKG...KFD............GKETKRegggnakkkgsFKLS.MNNLCETM.SRQLHDgGRqsvkipfhcnTTIKP
 1115- 1181 (72.82/44.04)	KPPKICV.KDIDSFANDdclKLDvlydftvqdawsYHTIKR...........FKPNdLSKPCRIMrTKNLYE.GH..........THIKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.78|      16|     809|     767|     796|      15
---------------------------------------------------------------------------
  771-  791 (22.74/18.51)	QHHhpaaATTPGHgTPLQGAN
 1586- 1601 (33.03/ 7.56)	QYH....SQEPPH.TPQSVAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09035 with Med12 domain of Kingdom Metazoa
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