<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09034

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSVNNKVTTIGTGSINPTALLTNMSNAIEKNKQWQRELLMERIRSHSSQHKTFQELSKAMRMGMLEKRYALDAVEKSNLQKCLDSMQHCIKVTSRQGLVERLESLSRQLGLKFMDDTKVLFISTDMFFLEIVLDANGALSDVKVHHECKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAEPKVKTKAFDAMQAVESDLYNLFQMQSFSKDTQQVLKDSIVGIVLKRHGGHPMRLVYFVSPYDLISLESKSLQSLSLDLLHNKQVGFSVTVNLEASSANKLQILPTVSFAKESQSGLEVPVFAPLNQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCGSPTTSQASAADINNSTVLEGQHKATLPMISNIMSLIIYTASEQQLKNSQKGLFVCLPDQTHCYFFTENKLLKSTLVQSIPFTEPSQVPKILDFLKRQALFYALLSSCVRPQSKMVNVDIDSTIILEVNAISYHQISVALQHPYEESMATVEFDLHNGNVQCIIYSLSNNYDLLSLKLTNVVQKCCSIPVTIRALLRYWDQERIKKFQRGIGAAAGSTGANTSNNGSNAVSNNSAYGNFNIAGVSNDPGGGGGGVGGGGGGCMNRGLGGSVKMEQALQQRSQLASTTTGYLKYKCGDIKQEDFHESPKSQTLAMVTDTTVANSMPVREVSSLGQQQQQTTHETLQQQTNTTFTAEREIADKYKNIWKDKTPAIKNCVSITPIGTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSINISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKCSTAAAMGSSSSSGLNPGALVRSSTSSTVVAAAAAAAAAMAALKNKDKSTVSPSAVSSAAAAAAAAVVKSSMGVVTPTMQQLKGVTGLNHMAAAAAGFGGNTATVNSLDLNAAMRKGVPSAVSLMTSTAVTATINSTPAQRRATQQVHRHHQQRQIPLQPLGSSEGDTNHTFNKNSSEYMVKSQSQEGLKLTINKTKAISTKKFGVNNDPTCKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLNKNKSLENSIEFLSNDNLRKSVKKSAVSTSSATSTHMSSLSAAPSQSALRIDYHADMIKILQYASPTMAASMEGFMKSFNTKFQIPKLSQRNATKTTTATTTAASVADTSKSGSLCITTSITKACPSSTTGVSDVQTPSLPPTSNPSSQQSTMAATETPAIVNANQSLVSLHVLKSSPISSTSPNHMNSLTATKSALNFVDNSNVSNNSMCNESLLATLAGE
Length1417
PositionMiddle
OrganismGlossina fuscipes fuscipes (Riverine tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.333
Instability index49.43
Isoelectric point9.41
Molecular weight151088.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09034
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     250.43|      58|      58|     936|     993|       1
---------------------------------------------------------------------------
  766-  835 (63.62/23.82)	TVSNSSTGI......TITPINTGSS....SinISGVSSK.DKKS..STTSSTCISNLPSSTT..SAkraldvqgelpkEKKRKKK
  836-  874 (27.02/ 6.19)	RDDSPMGPP..ekiySRQNSPAGSS....E..AAA...G.AVARkfSSPSS..................................
  876-  942 (47.15/15.89)	....PKGSSggllasCVT....GSSlttrP..SPKHSP....VY..SSPKHN..TASNSPKSPFGThspkhsssgkpsMSTLKNA
  943- 1010 (80.69/32.04)	TVASPKGDK......CSTAAAMGSS....S..SSGLNPG.ALVR..SSTSSTVVAAAAAAAAAMAA..lknkdkstvsPSAVSSA
 1011- 1047 (31.95/ 8.57)	AAAA..............AAAVVKS....S..MGVVTPTmQQLK..GVTGLNHMAAAAA..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     243.01|      67|     443|     678|     764|       2
---------------------------------------------------------------------------
  678-  764 (94.39/85.07)	QQQQQtTHETLQqqtnttFTaereiadkyknIwkDKTPAIKNCVSITPIGTQHDP....IQDVKRTGSIEIIPLTGQQHNS...IAGTVN...NGNS
 1080- 1127 (58.10/22.64)	......................................AVTATINSTP..AQRRA....TQQVHRHHQQRQIPL..QPLGS...SEGDTNhtfNKNS
 1131- 1200 (90.52/46.57)	MVKSQ.SQEGLK......LT...........I..NKTKAI....STKKFGVNNDPtckkLSASEKSWSPSQSKHTFQKSNSsgnLAGKLN...KNKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.46|      36|     443|      66|     111|       3
---------------------------------------------------------------------------
   70-  109 (50.36/53.74)	YALDAVEKSNlQKCLDSMQhciKVTSRQGLVERLESLSRQ
  182-  217 (62.10/32.56)	YQLNAEPKVK.TKAFDAMQ...AVESDLYNLFQMQSFSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.73|      19|     147|    1225|    1247|       6
---------------------------------------------------------------------------
 1225- 1245 (26.81/15.61)	SSATSTHMSSLSAapSQSALR
 1375- 1393 (33.92/14.18)	SSTSPNHMNSLTA..TKSALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.90|      36|     265|     219|     254|       7
---------------------------------------------------------------------------
  219-  254 (62.98/51.89)	QQVLKDSIVGIVLKRHGGHPMRLVYFVS.PYDLISLE
  485-  521 (59.92/48.95)	QHPYEESMATVEFDLHNGNVQCIIYSLSnNYDLLSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.64|      18|     147|    1057|    1074|       9
---------------------------------------------------------------------------
 1057- 1074 (32.20/21.11)	NSLDL..NAAMRKGV.PSAVS
 1203- 1223 (22.44/12.35)	NSIEFlsNDNLRKSVkKSAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.82|      16|      26|     613|     628|      11
---------------------------------------------------------------------------
  613-  628 (27.28/15.08)	GSVKMEQALQQ.RSQ.LA
  640-  657 (19.54/ 8.89)	GDIKQEDFHESpKSQtLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.28|      16|      18|    1308|    1323|      12
---------------------------------------------------------------------------
 1308- 1323 (29.70/15.31)	G.SLCITTSI.TKACPSS
 1326- 1343 (19.58/ 7.42)	GvSDVQTPSLpPTSNPSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09034 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVTATINSTPAQRRATQQVHRHHQQRQIPLQPLGSSEGDTNHTFNKNSSEYMV
2) DFHESPKSQTLAMVTDTTVANSMPVREVSSLGQQQQQTTHETLQQQTNTTFTAERE
3) GTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSINISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKCSTAAAMGS
4) KKFGVNNDPTCKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLN
5) SSTTGVSDVQTPSLPPTSNPSSQQSTMAATETP
1080
646
727
1153
1322
1132
701
960
1196
1354










Molecular Recognition Features






MoRF SequenceStartStop




NANANA