<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09018

Description Uncharacterized protein
SequenceMLSLLQEKRPLKRSRLGPPDVYPQEAKQREDELTPSNVKHGFPTTPPLSDEFGTAHTSNVNASKVASFFNAILAKKEELMTLQDTVRKKQQINFKDNFWPVSPRTKGALDAWFKDLAGNKPLLSLAKKAPSFNKKEEILITLCDHQVNMQRATWFIKLSAAYMVSVSESKNKKRNSFDPVPEWTGNLIKFMKELLPKLQEYYHLCEKSIPSEKSLLSGHGAPTTQNNTSMSLSHSSNNVTVVPSIASPVPMLSPANSQSSSSGGLGVLSSSSGSGVGTSSSQSSVTGTNQVPVSGSSISGIGSNFEDSRNALKYWNYCTQLSKYMHEESLLDRMEFLNWILELLDKMRIQANFDESLKRLVLTFALQYMQDFVQSERLCRKMAYIVAKKLANLLNAVIDQQQSLTNGKSENATHMEVDEEIDKKKAQLDPYEVAINEYLNCPHHRDIILYLSTILQVITVECPTAMVWCGIGENRAPAALCGSPLDHLPIAPSALPMPTKCPITNAEVRRQLRATEAEIILRSKHAENRWFAEKWQNANKNSYTHVLSILDYLDTHCFDRMDQTNSIDSLYANIFKPFVTVRREIGANGEVKEIRHEYDANVVDGTTVRILCEWAVSSQRWGEHRAIVVALLLDKRQIEVTTPNEPENNNGNTIGHSNNNNLNDDKDSIASGAGLIGGLPVFQSVLMNFLDHDAPVLDENGGMTNRTQFTNLVHLFSALIRYDVFSHNAYMHTLISRGDLLEGAANVESSKPSVTATTTVSGPVSNKPPSPPGNQGFDDDFGTSMDFKHNEFDDSNVDDDLDKLLQNIKEKGQAEAPDSPKIPDTSNSIGCDNANSSISRHYIYTKHFPIPQDDPAMSYSSESNQRYILLFGVGKERDEKKHAVKKISKEICKLFTKKFSIDVAEGGKLKKHSRNEFNFEATTSKCQNMAYFDQHVVTSQCAATVLEQLNAFALGSNNYLPVQEHVAFLFDLMEMALNIHSLLELCDQILKELPELENQLQTKKSNMIRSYTTSLGLYIVGILRRYHSCLLLSPEQTVSVFEGLCRIIKHVANPSECSSAERCILAYLSDLYESCFLLKSKDQEPEFFQQMAAIKKFKDIFNAPEQLGIVPQAYNQQFLQELFSFPKRGGKIDPNWLQQLHASPSNIYSFVSDVIVTVCRETDNDRLNDIAISCAELTAGCNALSEEWIAALQSICNAMKKPRYPQFCQVDIQNSKIHNSLAVFICILVARHCFSLADFVMNFALPTLANAYPVGGEISADAEAGARLTCHLVLKLFKTIEIPQPGMYSVSTSPNPLTAVGSSSNIKLSCDRHLLIGAHKNVPLEAVLAVLKAILIVVDTTALKTSNMSGNSSGGAFGSTGGKRSGFSTPVHPGSTPKSNERPVDLSQILGTSDLNSLNTEHDHDMTQQLTSTPSNTGALNNSEQISLLEFAQHVLKQICAQEHVLERCLKNAEKLCDMIIDEMLTPKQVQRILHMICYPESEYNIISELDQRSMIVRILENLGQWTLRISWLDLQLMHRQSINNPAELSSWLDTVARAAIDVFLMEEVVIGSGLKSEHRPKPSTWLVAPLVAKLTPAVQGRILRVAGQVLESMSYFSKVSKSDNNSSCSGDEREKSNSCGSASSSYSIGVNGSSSRSRKMPLNYQPFLGLILTCLKSQDEYKEGLLCSLYSQLSQCLQSYTEFDTMGGVDDPQGREEMLDALQLRFSLVGGMFESIQKNGTSITDWAILLAQLVCQGVIDLSTNKELFTTVVDMLTTLVHSTLVSDGQSERDEKFYSNLMKKLKKEIGEKNNASIKVIRQLLPLYKQPTEVISCEPAGVDQKGNKINDMDKKQLRISDKQRISVWDILEGHKNPAPLSWVWFGAVKLERKPLTYEEAHRNLKYHTHSLVKPSSYYYEALPLPPEDIEPIAEKIVKDEMKADTPSSVDQSPSAVVNMQQFNPNQMMQQNPNAIMQQQQQMPGVPSGIQQQMTVGNPQQSSQMSFMGSNGPQGMPQTGHNPQQQQWPGQNQFHPMQQQQQQQQFYQQQQGIQMNRFERPQQIGNSRQAIHNMLRQRQPLINQNNSSAFNTMQQQQQQRQTQGLPTQSQTGALNPVQQQQLQQQQFARGGMRSMAPSQLSGAAPNQMAPGINAVGMGGQSLGAQNPIMQQQISAQTINPQNNNQMIMNQNAGLMSTGNNNQNANIMANQSNTGLVGASGMMQQNVGVGGGAVSQNMVNQNAGQFQNFNQYQHQAINQSGNSSQLASFMAQQQQQQQQQQQQQQQRGPSGMASNRGQYMNQAPNVTMNNTMGQGAVPPYSRQQTSGGKPGVVSTQQQFQQQQRMQHQMMQMQGIGPQNSGAAGMTQTQNQSVGQQQTPNLVAHLQQRSMLNQPNMMGQQYQHQPPPY
Length2384
PositionKinase
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.467
Instability index49.25
Isoelectric point6.51
Molecular weight265088.01
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09018
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     660.71|     159|     177|    2025|    2201|       1
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 1929- 2077 (234.08/116.50)	QSPSAVVN........MQQFNPNQMMQQNPNAI..MQQQQQMPGVPS.G...........I.QQQMTVG..NPQQSSQMsFMGSNGpqGMPQTGHNPQQQQ.WPGQ..NQ..F.......HPMQQQ.......qqqqqfyQQQQGiQMNRFERPQQIGnsRQAIHNM...LRQRQPLINQN.NSSAFNTMQQQQQQR
 2085- 2251 (228.04/133.75)	QSQTGALNpvqQQQLQQQQFARGGMRSMAPSQLsGAAPNQMAPGINAVGMGGQslGAQNPIMQQQISAQtiNPQNNNQM.IMNQNA..GLMSTGNNNQNANIMANQ..SNTGL....VGASGMMQQnvgvgggavsqnmvNQNAG.QFQNFNQYQ.........H.........QA.INQSgNSSQLASFMAQQQQ.
 2252- 2379 (198.58/92.15)	...........QQQQQQQQQQQRGPSGMASNR..GQYMNQ.APNVTMNNTMGQ..GAVPPYSRQQTSGG...............KP..GVVSTQQQFQQQQRMQHQmmQMQGIgpqnSGAAGMTQT..........................QNQSVG..QQQTPNLvahLQQRS.MLNQP.N......MMGQQYQH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.15|      25|     177|     634|     660|       2
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  634-  660 (42.79/30.04)	DKRQIEvtTPNEPE.NNNGNTIGHSNNN
  810-  835 (41.35/22.90)	EKGQAE..APDSPKiPDTSNSIGCDNAN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.70|      26|     177|      40|      67|       3
---------------------------------------------------------------------------
   40-   67 (40.10/29.65)	HGFPTTPPlSDEFGTAHTSNvNASKVAS
  219-  244 (47.59/26.55)	HGAPTTQN.NTSMSLSHSSN.NVTVVPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.51|       8|     177|    1374|    1383|       4
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 1358- 1365 (14.93/ 6.76)	GST..GGKRS
 1374- 1383 (10.58/11.61)	GSTpkSNERP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.05|      57|     177|     391|     451|       5
---------------------------------------------------------------------------
  391-  451 (84.58/70.61)	ANLLNAVIDQQQSL.TNGKSENATHmEVDEE.IDKKKAQ.LDPYEVAINEYlncPHHRDIILYL
  572-  631 (83.47/55.88)	ANIFKPFVTVRREIgANGEVKEIRH.EYDANvVDGTTVRiLCEWAVSSQRW...GEHRAIVVAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.09|      26|     176|    1467|    1492|       6
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 1433- 1470 (33.12/17.40)	QHVLKQICAQEHVLErclknaeklcdmI.IDEMLTPKQV
 1471- 1496 (46.76/27.55)	QRILHMICYPESEYN............I.ISELDQRSMI
 1497- 1514 (18.21/ 6.29)	VRILENL....GQWT............LrISWLD.....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.18|      12|      19|    1115|    1126|      12
---------------------------------------------------------------------------
 1115- 1126 (22.16/11.85)	NQQFLQELFSFP
 1133- 1144 (24.01/13.53)	DPNWLQQLHASP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.43|      15|      19|    1385|    1399|      13
---------------------------------------------------------------------------
 1385- 1399 (25.09/18.05)	DLSQILGT..SDLNSLN
 1405- 1421 (21.34/13.85)	DMTQQLTStpSNTGALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.59|      21|      24|     257|     277|      14
---------------------------------------------------------------------------
  257-  277 (37.90/16.82)	SQSSSSGGLGV.LSSSSGSGVG
  281-  302 (33.69/14.25)	SQSSVTGTNQVpVSGSSISGIG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.93|      20|     177|    1680|    1710|      15
---------------------------------------------------------------------------
 1689- 1708 (35.76/39.81)	GVDDPQGREEMLDALQLRFS
 1819- 1838 (35.17/10.81)	GVDQKGNKINDMDKKQLRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.76|      15|      19|    1761|    1775|      22
---------------------------------------------------------------------------
 1761- 1775 (25.06/18.67)	HSTLVSDGQSERDEK
 1777- 1791 (24.71/18.29)	YSNLMKKLKKEIGEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.95|      20|      20|     946|     965|      24
---------------------------------------------------------------------------
  946-  965 (33.38/23.73)	LEQLNAFALGSNNYLPVQEH
  969-  988 (33.58/23.93)	LFDLMEMALNIHSLLELCDQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.98|      21|      25|    1712|    1735|      27
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 1712- 1735 (30.51/30.64)	GMFE.SIQKN.GTSITDwaiLLAQLV
 1738- 1760 (26.46/15.95)	GVIDlSTNKElFTTVVD...MLTTLV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09018 with Med12 domain of Kingdom Metazoa
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