<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09015

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDDWQSQQFRQSAIAKIKDVLAATGQDPNKNAGVMENHIFKKAKNKEEYLTLLGKVYIHFKDTSRKPQPNAEMTQQNMMQDPLNALQNLASQGNRNPQMMSMAGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQIPMGGGVPGQQQGSVVGGPGSQQQMMNQMVGPGGLQMNIMGGPGGAQQSQMVPNAQQMTSGGSGPGVSQGLGQGQMNQMAGPGSGGPMGSGAGGPSQMLMQAAAGQMQGGPMNVNAMNVQQLPGQMPQQQVQQMSMQQHSQLNQMMNARMNQTGGGNITVAAGPTSNAPQGMQGLPSNLQQNQAAGAVAQMHSSNVSGGPSVSGTLGNNAGQGNLNQMLNMPPNMQKNPNMPLPQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLVAQQQQQQLHQVVNNQQQLQQQQANQTGPGQSNQTLPNPQMIPSPALVPTSSPQTSGLLQNPNQRQQMRQSPSSNLNTPGQVTNSPFNPHEEQLYREKYKQLTKYIEPLKRMVAKFTNDGAQIEGQTKMRKLLEILSNPSQRVSLETLHKCEKVLEKMEIGNIVQQFGKSPNPLMEVITNTLQSPIANHTLYRTFRPTLELLLGTDISAPPPPKKSCVSAKTTNPNETEIPHLLQGELARLDTKFKVALDTTAQNNTQSIKLICCLDDKKLPSVPPININIPEEYPLSSPDCILIEQDYTCTPFLKSVQSAFMARITKLPKIYSLSHLLNTWEMSVRQACSPNANANKPICELTALFGM
Length767
PositionTail
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.03
Grand average of hydropathy-0.625
Instability index59.81
Isoelectric point9.38
Molecular weight82785.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09015
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     554.31|      73|      73|     105|     177|       1
---------------------------------------------------------------------------
  105-  177 (146.10/41.16)	GGPGGPVT.....ASNLLQSLNQQRPGQQQMQQMQG.......MRPQI...PMGG.GVPGQQQGS...VVGGPGS.QQQMMNQMVG.PG.GLQMN
  180-  228 (80.68/19.14)	GGPGG................AQQSQMVPNAQQMTS.................GG.SGPGVSQG.....LG......QGQMNQMAG.PGsGGPMG
  229-  290 (86.01/20.93)	SGAGGP...........SQMLMQAAAG.....QMQGgpmnvnaMNVQ....QLPG.QMPQQQVQQ...MSMQQHS.Q...LNQMMN.A....RMN
  291-  367 (94.93/23.94)	QTGGGNITvaagpTSNAPQGM.QGLPSNLQQNQAAG.......AVAQM...H.SS.NVSGGPSVS...GTLGNNA.GQGNLNQMLNmPP.NMQKN
  368-  441 (88.22/21.67)	..PNMPLP.....QNNQMFNVNRGVVGQQQFLR.QS.......PSPSTvssPAGG.LVAQQQQQQlhqVVNNQQQlQQQQANQ.TG.P..G.QSN
  455-  501 (58.37/11.62)	LVPTSSPQ.....TSGLLQNPNQ....RQQMRQ..............S...PSSNlNTPGQVTNS...PF.NPHE.EQ.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.43|      26|      73|     614|     653|       2
---------------------------------------------------------------------------
  614-  639 (46.88/47.28)	DISAPPPPKK....SCVSAK...TTNPNETEIP
  658-  690 (36.54/12.65)	DTTAQNNTQSikliCCLDDKklpSVPPININIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.25|      19|      40|     540|     558|       4
---------------------------------------------------------------------------
  537-  555 (30.37/23.83)	MRKLLEILS...............NPSQRVSLET
  556-  589 (22.88/15.85)	LHKCEKVLEkmeignivqqfgkspNPLMEVITNT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09015 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FKDTSRKPQPNAEMTQQNMMQDPLNALQNLASQGNRNPQMMSMAGGPGGPVTASNLLQSLNQQRPGQQQMQQMQGMRPQIPMGGGVPGQQQGSVVGGPGSQQQMMNQMVGPGGLQMNIMGGPGGAQQSQMVPNAQQMTSGGSGPGVSQGLGQGQMNQMAGPGSGGPMGSGAGGPSQMLMQAAAGQMQGGPMNVNAMNVQQLPGQMPQQQVQQMSMQQHSQLNQMMNARMNQTGGGNITVAAGPTSNAPQGMQGLPSNLQQNQAAGAVAQMHSSNVSGGPSVSGTLGNNAGQGNLNQMLNMPPNMQKNPNMPLPQNNQMFNVNRGVVGQQQFLRQSPSPSTVSSPAGGLVAQQQQQQLHQVVNNQQQLQQQQANQTGPGQSNQTLPNPQMIPSPALVPTSSPQTSGLLQNPNQRQQMRQSPSSNLNTPGQVTNSPFNPHEEQLYREKY
61
507










Molecular Recognition Features






MoRF SequenceStartStop




1) YLTLLGKVY
50
58