<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09009
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MNFTNSVNVSVETTCESQIQEISYDGTEIYQPPPSLSETLAKCAAKIDFSKTSLDDLKKEEKTTAEDNDKDTTLFQPSLWPWDSVRNKLNDALTEICVLADVLSIAKDKRYLVLDPVPEEPEETKPIVQVYSRKKALGQAAQILLSGAERLRNSHTEQRTRNVADFHIELLRLRQNWRLKKVGNSNSIIGDLSYRTAGSKFGMSGTFEVTKAEETIDEEPSTSLSATGGGGNNNGLLNPSPKNSSALRVIVPAELQGVAYFKVITQKDQEDLCTAIVNLVGHGPNITQQGYGVWQKTIEDAQNVLFCKELFSQLAREAIQIQAPIPHVVIGNQIRATLLPGIQLIVSLCHSTTVDNSQPTPINDHDHDHVLEHSLHQLLREVHHKNSHHPFPHPASGPLGPSKKRMLAGPLAADRQTVLDMTKAQTILEQIIAQAQHIFMRKRTQYVLDTLARDVKDPQIVSHWNGMSKPTMSCVKINIVTHGYDTIYRTSLMIHVHERSLKVICRDGRVMYLSYEPQELRDLILCQINSHQISCLINLARCMAWPVISNSNHLGIGKVEPLGNASSCLLASPNSDRMIAVQIRCTQSQMDIKVYIARSPRHDFFPSPLVPEKFWENLGGHFKEVRFDKIEGKSFLNKIEFLMASLNSNAS |
Length | 651 |
Position | Head |
Organism | Glossina brevipalpis |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea>
Glossinidae> Glossina.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.338 |
Instability index | 43.45 |
Isoelectric point | 6.79 |
Molecular weight | 72790.21 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP09009
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 166.53| 52| 161| 386| 439| 1
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386- 439 (84.51/69.85) NSHHpFPHPASGPLGPSKKRMLAGPlAADRQTVLDM..TKAQTILEQIIAQA.QHIF
550- 604 (82.02/57.59) NSNH.LGIGKVEPLGNASSCLLASP.NSDRMIAVQIrcTQSQMDIKVYIARSpRHDF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 264.20| 90| 159| 49| 145| 2
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49- 145 (130.42/116.33) FSKTSLDDLKKEEKTTA....EDNDKDTTLFQPSlwPWDS..VRNKLNDALTEICVLaDVLSiAKDKRYL...VLDPVPEEPEETKpivQVYS.RKKALGQAAQILL
207- 306 (133.78/93.81) FEVTKAEETIDEEPSTSlsatGGGGNNNGLLNPS..PKNSsaLRVIVPAELQGVAYF.KVIT.QKDQEDLctaIVNLVGHGPNITQ...QGYGvWQKTIEDAQNVLF
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