<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09007

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVQSVCGCKEGSVLLQNNVLCRISTKNLIVFCVHQNLHSQIYICDIVKPWQSYKICSSKAVASVLEWNPTGELLLVGYKHGLAEIWGMKANCMNSWFLLYTVNLPCEEIINVKFFHNSKSTYFNMQKKDLQNYSDKYERLDQRPTLAYFGCSPAEGCFLLTASGLMGVFTIPRILANMETSNLSSPSELNIFTNSIGLSRCFITHCSISYCPTGRFNVAVNNWSEPRISCFKIGVEREQDDTLNLKCGALASIFLQRVDNENKEISVVHWRTVNCEEVAFVVYDCQEGSFIEQWNLIKKHQQVHKLLQKNKTDFMQWEQWEITAKLALTSRVCDLNLSKLPSESLLLFAILRDNSVQILETGLKKIGSTVFERVVEDQIRAPCKLLTSDCTHLNQLLILFDSLGQMYAMQVPTSHYDKNYKMSPLAVPVSLLEYSVITGIDAGDVLMLNLSHLEAITEKLTENFSRQTAYVRHFYYSNFLSLKSNICRIQTKQQDFDDLITLHAIAIAFKSLLRPSDLSSQDKGPAENLSMILSEPVGDVDKVLCILDAKDFTVEPATLQSLQQLIQWVSDLALNILHKLTEDVLKPKFNKRHGYEICRDVIAVSSVRELLVMIRFWGLLNPHCLPIYTKSVDNFDVLPVMFRLLTRLMQNTNEPDDSLLDECSVLSTQVLVPTRHINTPTTLLNNNATSKLFPFVFQTTVEPLNLQDVHYEEVLFSHSIKDDVSNLHLGTHVRLLRRCSRCGFINNINKMTKTAALKTWYQRWKYCHCGGFWKLV
Length781
PositionTail
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.09
Grand average of hydropathy-0.043
Instability index42.29
Isoelectric point7.24
Molecular weight89213.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09007
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.68|      60|     154|      57|     119|       1
---------------------------------------------------------------------------
   57-  119 (99.77/86.26)	SYkiC.SSKAVASVLEWN.PTGELLLVGYKHGLAEIWGMKANCMNSWFlLYTVNLPCEEIINVKF
  214-  275 (97.91/73.12)	SY..CpTGRFNVAVNNWSePRISCFKIGVEREQDDTLNLKCGALASIF.LQRVDNENKEISVVHW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.39|      54|     106|     394|     449|       2
---------------------------------------------------------------------------
  394-  449 (84.56/74.83)	DCTHLNQLLILFDSLGQMYAMQVPTSHYDKNYKMSpLAVPVSLLEySVITGIDAGD
  503-  556 (88.83/66.64)	DLITLHAIAIAFKSLLRPSDLSSQDKGPAENLSMI.LSEPVGDVD.KVLCILDAKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.66|      10|      23|     295|     304|       5
---------------------------------------------------------------------------
  295-  304 (19.48/12.91)	FI..EQWNLIKK
  319-  330 (15.18/ 8.41)	FMqwEQWEITAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.32|      12|     465|      20|      32|       6
---------------------------------------------------------------------------
   20-   32 (18.57/15.22)	LQNNVlCRISTKN
  487-  498 (22.75/13.64)	LKSNI.CRIQTKQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09007 with Med16 domain of Kingdom Metazoa
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