<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09003

Description Uncharacterized protein
SequenceMAPAPQPLEQALAGYLPQGQEGSSRMNTISLSVLIDFTIQRTYHDLTVLAELLPRKSDMERKIEIYNFSARTRQLFIRLIALVKYANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDPITPQEKKQTLLRLNQVIQHRLVTGKLMPQMREFKIRNGRVIFEVKHEFNVSLTVMGDSANVPWRLLDIDILVEDKETGDGKALVHPLQVNYIHQLIQVRLVENPNALCEVYNCLHYFCQSLQLEVLYTQSLRLSYERLDDNINVEEYIPGYKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDCKPWIAVLNAFSSIFIQSLVNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIMPEMQASLNGDRNKLPQIMTELRYWITHRRCEKTLQHLPATATEDLTFLNMPDHPLLQSGRHKIYVKLHRHPNVVLVVHLKEKSSMPNEMEYTFYLGLLVYQSNETEILSEDLTKQLVPIQTSSSNAENQAGHHHEIPKVFAKLLRLIEFDTFVATHGPGTDVDDLPPHKRKSNSELGAPPTKQAKTIYPAYIIPDLAHVVAMCDEKIPFLNLAQALTKYNVPHCGLQVESNAISLVLKIITLPKPTPPDDRKTQFPVIESNVWDDLMKRVLSISIRSHMNKSNKIRSWVMEFIFYSTPLQSTHPREQGTRRTLYLSYDQISNYSQTVEDLLKDWSKIVYLYTLVCSFAEHIKNKRLNITDMLNINSYNYTNLLLGYGPKKEVLCNIFWSAELGGFHMTFLGGITAVNAHSVIRDQLAIYLNTKHNLTQIVQLLHETYNPLSSIAKLPIIPHLGIPRPQVPVLSFCILPQSPCVIRLAYQAVYCLEIKFRSGSLISIRDGAYSRFDRNLIEEFTPIQGLKGFLSKYVDENAIYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSIGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSASGGGGSSSSNTQNHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSTASNPNTNSSSGSSSQVINRMPLPNRSYAGAVPTLLTHEKFDLLCRPSAHPNKSISSTSDISPLERFLGCVYLRRQLYRNIQNEDTLTALNSNEPGVVLFKVDGLQCQVILNQVHMQSLHLKVNQLPPPHTPDSKQPFQLSPDDLLIIEQFFDTRVAAPPYRPNALHGFSRVLSCAPQVLKDFVQIMRLEMKPDLGGDQLKWTVQFCMRVPPSAAPIVPIGSPGVLIVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQPQSPPAIHASECLRNFARAYTQHAQCSLFPAVRDLLTTLQLPNDIPPQNQAIGPPVGATFGSSPNPMLHSPMQQMAGPVGPPQVGPGYPQMPQNPGPQ
Length1560
PositionTail
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.289
Instability index52.93
Isoelectric point8.61
Molecular weight174365.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09003
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     317.75|      55|      56|    1063|    1117|       1
---------------------------------------------------------------------------
 1020- 1070 (64.60/23.24)	SPIGGEDNFGGPGSASGasAGGSSP........FLSIGMRGPQ....SPRDSglrfP.....APHTPP
 1071- 1128 (102.66/41.28)	SSSNPHTPASPHPSASG..GGGSSSSNTQNHPNYNLTSPPGPH....MPHPS....PgalMPSSPLNP
 1129- 1173 (73.93/27.67)	QPS.PHMVHSPGPNTLY..MQGHQDSPFAAMSPANTNWPGSPS....MPRPS................
 1174- 1226 (45.00/13.96)	..........PRPGQSP..DHKSGQSTASN.PNTNSSSGSSSQvinrMPLPN.rsyA.gaVPTLLTHE
 1532- 1557 (31.56/ 7.59)	.........................SPMQQMA.....GPVGP......PQVG....P..gYPQMPQNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.32|      26|      83|     338|     364|       2
---------------------------------------------------------------------------
  338-  364 (41.52/26.66)	VQSDPNEIGRPlAVVHVPSLGAKESAE
  424-  449 (45.80/25.47)	IQSLVNLQGTP.AILTVPVLTPCLRAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.29|      11|      22|     974|     984|       6
---------------------------------------------------------------------------
  974-  984 (20.53/14.73)	GAYSRF.DRNLI
  995- 1006 (15.77/ 9.41)	GFLSKYvDENAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.01|      12|      22|     914|     925|       7
---------------------------------------------------------------------------
  914-  925 (21.34/12.40)	PLSSIAKLPIIP
  935-  946 (23.67/14.73)	PVLSFCILPQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.96|      19|      22|     241|     259|       8
---------------------------------------------------------------------------
  241-  259 (32.32/20.48)	DGKALVHPLQ.VNYIHQLIQ
  265-  284 (29.64/18.10)	NPNALCEVYNcLHYFCQSLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.75|      21|      22|    1450|    1470|       9
---------------------------------------------------------------------------
 1450- 1470 (37.05/24.10)	SSNLTQLAEKREQ.PQSP..PAIH
 1472- 1495 (27.70/15.80)	SECLRNFARAYTQhAQCSlfPAVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      13|     860|     638|     655|      10
---------------------------------------------------------------------------
  638-  655 (17.87/17.58)	DDLPPHkrksNSELGaPP
 1505- 1517 (27.71/11.91)	NDIPPQ....NQAIG.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.61|      11|      27|     163|     189|      11
---------------------------------------------------------------------------
  148-  158 (20.38/20.80)	RLPTCIRERIV
  174-  184 (19.24/ 9.29)	RLNQVIQHRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.56|      24|      27|     808|     833|      12
---------------------------------------------------------------------------
  808-  833 (39.35/32.39)	DWSKI.VYLYT.LVCSFAEhiKNKRL.NI
  835-  861 (30.22/17.44)	DMLNInSYNYTnLLLGYGP..KKEVLcNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.40|      32|     300|      71|     102|      15
---------------------------------------------------------------------------
   71-  102 (52.78/38.78)	RTRQLFI.RLIALVKYANSVSKV.DKSANIMSFL
  371-  404 (45.62/32.47)	RSDHLSMeRLIVHTVYIRSVSRLsDLKLEFQAFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.16|      11|      29|    1386|    1398|      16
---------------------------------------------------------------------------
 1386- 1398 (17.27/20.70)	QLKwtVQFCM...RVP
 1416- 1429 (14.89/ 7.42)	RLK..ILFFLqitRIP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09003 with Med14 domain of Kingdom Metazoa
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