<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09000

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQSHQTNGASLEDCHTNFFALTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRIQSTKQDNSDLNALGDEVNNTKVHPPLSLAAAKELWIFWYGEEPDLTELVDAELLRVAANQATWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQDQTSPNNSPVVAEASGENATTNPSGSTMPKPRKVILAPFGMAATLTGNSYKANDPMAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNTVDGLSNVRKPLTETISNKLTINTNQTASAKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANATISANCNENVSVIGNGGGSGTGAGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTNTKSLTKVTTTATASALPVSSTHMMAGSSASAVRVSHSSSTFKPYHAFGFASSGSSSSSSNSSSSSSVGNSLAHHILVQLSSNSHIHNNQQLPIASGSSSGHINQSCIPSTEMSKVCTKTNTLLRIHRIPPFHKRHLIKSDGKDYWLIGNNSTNSKITISSSCFIDSNQKQQQTNYPRAALYQNSACTSEITRKQRSLAAQHHHAAAASTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPTSVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNTMGGGGPNLNDNMPTSGLGGTNQPASVGRCTPTIQQQQSSSSQQQQHSHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASTGDVKLESSGLQANPTSSSVTSTSHSTTTLNTILPNNLKRNSSTQSSAGNSVHAMHDFLSLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSFHTIKRFKPNDLSKPCRIIRTKNLYEGHTHIKPLMPSPRSVYGTQLLAVDSVQATQMASVSGADSSNIMADIPAGLVGIASNNQNASRSANDNSVGPLTTGSSSTASNFFEELDIKTEIMSGMASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAASNATIDDLKRSTNPAILANSNVAITNSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGPNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSKYAPLTNLPSQTMAPLITPPNCVYKPSWQPTRSTHQQPQQQQQLQQHNQSLQQQQNHQQQQPQHQQHQQLHELLSSAPRTPLQQPRTPLGPMSSSPMHNTVPTPLSSGGGGGGSLLLNQLNCPQAALTNTPPAMQQLMQRAGMSPISPASHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPTASLGLFSGAVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGAYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFISKSNGSSGNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTAIANVLEYMDANDIISLALEQARLAFDSSRMDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYIPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDIVYLVIAPENDYVISKTKTYFKELSTTYEMCKLGKHTLMYGWGGMLTVGQRPPTEKPFTTNLDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPNDKTLLNPPDVNVHVASHNNTRLSASGNTSSPMAGTITGLEGSDRGDHTSSTPMEHGDLSQHANADTAGNMNDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPDSVKANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDEQNRRPYKMYTPPYILAPIHEKNDKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVIGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPTWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2806
PositionMiddle
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.408
Instability index51.22
Isoelectric point6.28
Molecular weight303964.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09000
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.19|      19|      21|    1423|    1443|       1
---------------------------------------------------------------------------
  906-  922 (33.92/15.93)	QQQQSSSS...QQQQH.SHQQ
 1423- 1443 (33.16/21.86)	QPTRSTHQqpQQQQQLQQHNQ
 1446- 1463 (40.11/20.26)	QQQQN.HQ..QQQPQHQQHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.30|      16|      22|    1532|    1553|       2
---------------------------------------------------------------------------
 1532- 1553 (26.43/19.66)	M...QRagMSPISPashvPFPH....TSP
 1555- 1577 (24.87/ 6.81)	MhhqQR..QTPIHP....PPPYevavASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.56|      23|      23|     784|     806|       3
---------------------------------------------------------------------------
  773-  795 (24.54/ 7.86)	P..VPsvgsPGT...pAP.SPH.PN..STLSQ
  796-  821 (32.76/13.52)	PTSVP....PADQLL.AM.SPRaPTsvSNLQQ
  863-  884 (29.12/11.02)	PPSVE....GIHNTM...gGGG.PN..LNDNM
 1316- 1329 (25.14/ 8.27)	PT..P....PSHE......QHH.PN..SS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.83|      14|      24|     563|     576|       4
---------------------------------------------------------------------------
  563-  576 (24.62/10.77)	GSSASAVRVSHSSS
  590-  603 (23.06/ 9.58)	GSSSSSSNSSSSSS
  606-  619 (21.15/ 8.11)	NSLAHHILVQLSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.52|      19|      23|    1007|    1028|       5
---------------------------------------------------------------------------
 1007- 1028 (31.12/31.12)	AMHDFLSL...YkppKICVKDIDSF
 1029- 1050 (32.40/21.20)	ANDDCLKLdvlY...DFTVQDAWSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.86|      16|      23|    1981|    1996|       6
---------------------------------------------------------------------------
 1981- 1996 (28.45/14.64)	PMLQNAFHSKSRSAAG
 2007- 2022 (30.41/16.15)	PLTWRQFHRLAGRASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.18|      14|      23|    1472|    1486|       7
---------------------------------------------------------------------------
 1472- 1486 (22.44/13.62)	PrTPLQQPRTPLGPM
 1496- 1509 (29.74/14.42)	P.TPLSSGGGGGGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.48|      12|      22|     697|     708|       9
---------------------------------------------------------------------------
  697-  708 (21.85/12.98)	SSCFIDSNQKQQ
  721-  732 (20.63/11.80)	SACTSEITRKQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.00|      25|      25|    1107|    1131|      10
---------------------------------------------------------------------------
 1107- 1131 (41.02/22.70)	ASV.SGADSSNIMADIPAGLVGIASN
 1135- 1157 (35.84/18.72)	ASR.SANDNS..VGPLTTGSSSTASN
 1170- 1191 (24.14/ 9.72)	SGMaSGTSSISPCKDSKSGIGG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.15|      23|      26|    1904|    1928|      11
---------------------------------------------------------------------------
 1903- 1927 (29.92/26.71)	YMDaNDIISLALE....QARLAFdSSRMD
 1928- 1954 (34.24/20.23)	VMD.QQIIAFSHRksgsQTILAL.TGRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.36|      38|      38|     403|     440|      12
---------------------------------------------------------------------------
  403-  440 (65.28/36.74)	TNQTASAKSLAYMVERLKID..PKKVQNHYDALTSNYTCN
  442-  481 (64.07/35.92)	TNTHAPPQAATEMPERAWQDcvTNSLHAQYANATISANCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.28|      19|      26|    1051|    1073|      14
---------------------------------------------------------------------------
 1051- 1073 (30.86/26.91)	HT.IKRFKPNdlskPCRIIRTKNL
 1077- 1096 (31.43/17.34)	HThIKPLMPS....PRSVYGTQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      14|      15|    1731|    1744|      15
---------------------------------------------------------------------------
 1731- 1744 (25.21/13.57)	SGGGGGGIGSALDS
 1747- 1760 (23.69/12.22)	SLAGAGSSSSTTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.55|      15|      26|     964|     978|      16
---------------------------------------------------------------------------
  964-  978 (25.82/15.17)	LQAN.....PTSSSVTSTSH
  987- 1006 (20.73/10.18)	LPNNlkrnsSTQSSAGNSVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.29|      40|     517|     736|     778|      17
---------------------------------------------------------------------------
  736-  778 (67.13/43.75)	AQHHHAAAASTPGHGTPLQGANGGASSYSRNSVMDTMpvpSVG
 1256- 1297 (60.16/38.19)	ANSNVAITNSTAGAAVMVALQNCNNSSASSTSAVSSL.nnSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.47|      11|      30|    1686|    1696|      23
---------------------------------------------------------------------------
 1686- 1696 (20.53/11.77)	IGNIRGADS.GA
 1717- 1728 (14.94/ 6.37)	VGNIRALSAfGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.36|      13|     702|     847|     862|      26
---------------------------------------------------------------------------
  823-  835 (24.27/12.39)	PT...PIEHLLDKNTP
  847-  862 (20.09/17.54)	STtasPYVHPTPSVEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09000 with Med13 domain of Kingdom Metazoa
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