<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP09000

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQSHQTNGASLEDCHTNFFALTDLCGIKWRKFVNSERPNASSDPLDDPILRSYSRCMQADILCVWRRIQSTKQDNSDLNALGDEVNNTKVHPPLSLAAAKELWIFWYGEEPDLTELVDAELLRVAANQATWNGTWERGLTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQDQTSPNNSPVVAEASGENATTNPSGSTMPKPRKVILAPFGMAATLTGNSYKANDPMAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNTVDGLSNVRKPLTETISNKLTINTNQTASAKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANATISANCNENVSVIGNGGGSGTGAGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTNTKSLTKVTTTATASALPVSSTHMMAGSSASAVRVSHSSSTFKPYHAFGFASSGSSSSSSNSSSSSSVGNSLAHHILVQLSSNSHIHNNQQLPIASGSSSGHINQSCIPSTEMSKVCTKTNTLLRIHRIPPFHKRHLIKSDGKDYWLIGNNSTNSKITISSSCFIDSNQKQQQTNYPRAALYQNSACTSEITRKQRSLAAQHHHAAAASTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPTSVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNTMGGGGPNLNDNMPTSGLGGTNQPASVGRCTPTIQQQQSSSSQQQQHSHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASTGDVKLESSGLQANPTSSSVTSTSHSTTTLNTILPNNLKRNSSTQSSAGNSVHAMHDFLSLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSFHTIKRFKPNDLSKPCRIIRTKNLYEGHTHIKPLMPSPRSVYGTQLLAVDSVQATQMASVSGADSSNIMADIPAGLVGIASNNQNASRSANDNSVGPLTTGSSSTASNFFEELDIKTEIMSGMASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAASNATIDDLKRSTNPAILANSNVAITNSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGPNLDSGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSKYAPLTNLPSQTMAPLITPPNCVYKPSWQPTRSTHQQPQQQQQLQQHNQSLQQQQNHQQQQPQHQQHQQLHELLSSAPRTPLQQPRTPLGPMSSSPMHNTVPTPLSSGGGGGGSLLLNQLNCPQAALTNTPPAMQQLMQRAGMSPISPASHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPTASLGLFSGAVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGAYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFISKSNGSSGNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTAIANVLEYMDANDIISLALEQARLAFDSSRMDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYIPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDIVYLVIAPENDYVISKTKTYFKELSTTYEMCKLGKHTLMYGWGGMLTVGQRPPTEKPFTTNLDNWLRTMEDTTLAEKLRLYAHAFQHMLVPYLNRIPNDKTLLNPPDVNVHVASHNNTRLSASGNTSSPMAGTITGLEGSDRGDHTSSTPMEHGDLSQHANADTAGNMNDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPDSVKANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDEQNRRPYKMYTPPYILAPIHEKNDKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVIGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPTWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2806
PositionMiddle
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.06
Grand average of hydropathy-0.408
Instability index51.22
Isoelectric point6.28
Molecular weight303964.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP09000
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.19|      19|      21|    1423|    1443|       1
---------------------------------------------------------------------------
  906-  922 (33.92/15.93)	QQQQSSSS...QQQQH.SHQQ
 1423- 1443 (33.16/21.86)	QPTRSTHQqpQQQQQLQQHNQ
 1446- 1463 (40.11/20.26)	QQQQN.HQ..QQQPQHQQHQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.30|      16|      22|    1532|    1553|       2
---------------------------------------------------------------------------
 1532- 1553 (26.43/19.66)	M...QRagMSPISPashvPFPH....TSP
 1555- 1577 (24.87/ 6.81)	MhhqQR..QTPIHP....PPPYevavASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     111.56|      23|      23|     784|     806|       3
---------------------------------------------------------------------------
  773-  795 (24.54/ 7.86)	P..VPsvgsPGT...pAP.SPH.PN..STLSQ
  796-  821 (32.76/13.52)	PTSVP....PADQLL.AM.SPRaPTsvSNLQQ
  863-  884 (29.12/11.02)	PPSVE....GIHNTM...gGGG.PN..LNDNM
 1316- 1329 (25.14/ 8.27)	PT..P....PSHE......QHH.PN..SS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.83|      14|      24|     563|     576|       4
---------------------------------------------------------------------------
  563-  576 (24.62/10.77)	GSSASAVRVSHSSS
  590-  603 (23.06/ 9.58)	GSSSSSSNSSSSSS
  606-  619 (21.15/ 8.11)	NSLAHHILVQLSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.52|      19|      23|    1007|    1028|       5
---------------------------------------------------------------------------
 1007- 1028 (31.12/31.12)	AMHDFLSL...YkppKICVKDIDSF
 1029- 1050 (32.40/21.20)	ANDDCLKLdvlY...DFTVQDAWSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.86|      16|      23|    1981|    1996|       6
---------------------------------------------------------------------------
 1981- 1996 (28.45/14.64)	PMLQNAFHSKSRSAAG
 2007- 2022 (30.41/16.15)	PLTWRQFHRLAGRASG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.18|      14|      23|    1472|    1486|       7
---------------------------------------------------------------------------
 1472- 1486 (22.44/13.62)	PrTPLQQPRTPLGPM
 1496- 1509 (29.74/14.42)	P.TPLSSGGGGGGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.48|      12|      22|     697|     708|       9
---------------------------------------------------------------------------
  697-  708 (21.85/12.98)	SSCFIDSNQKQQ
  721-  732 (20.63/11.80)	SACTSEITRKQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.00|      25|      25|    1107|    1131|      10
---------------------------------------------------------------------------
 1107- 1131 (41.02/22.70)	ASV.SGADSSNIMADIPAGLVGIASN
 1135- 1157 (35.84/18.72)	ASR.SANDNS..VGPLTTGSSSTASN
 1170- 1191 (24.14/ 9.72)	SGMaSGTSSISPCKDSKSGIGG....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.15|      23|      26|    1904|    1928|      11
---------------------------------------------------------------------------
 1903- 1927 (29.92/26.71)	YMDaNDIISLALE....QARLAFdSSRMD
 1928- 1954 (34.24/20.23)	VMD.QQIIAFSHRksgsQTILAL.TGRLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.36|      38|      38|     403|     440|      12
---------------------------------------------------------------------------
  403-  440 (65.28/36.74)	TNQTASAKSLAYMVERLKID..PKKVQNHYDALTSNYTCN
  442-  481 (64.07/35.92)	TNTHAPPQAATEMPERAWQDcvTNSLHAQYANATISANCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.28|      19|      26|    1051|    1073|      14
---------------------------------------------------------------------------
 1051- 1073 (30.86/26.91)	HT.IKRFKPNdlskPCRIIRTKNL
 1077- 1096 (31.43/17.34)	HThIKPLMPS....PRSVYGTQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      14|      15|    1731|    1744|      15
---------------------------------------------------------------------------
 1731- 1744 (25.21/13.57)	SGGGGGGIGSALDS
 1747- 1760 (23.69/12.22)	SLAGAGSSSSTTPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.55|      15|      26|     964|     978|      16
---------------------------------------------------------------------------
  964-  978 (25.82/15.17)	LQAN.....PTSSSVTSTSH
  987- 1006 (20.73/10.18)	LPNNlkrnsSTQSSAGNSVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.29|      40|     517|     736|     778|      17
---------------------------------------------------------------------------
  736-  778 (67.13/43.75)	AQHHHAAAASTPGHGTPLQGANGGASSYSRNSVMDTMpvpSVG
 1256- 1297 (60.16/38.19)	ANSNVAITNSTAGAAVMVALQNCNNSSASSTSAVSSL.nnSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.47|      11|      30|    1686|    1696|      23
---------------------------------------------------------------------------
 1686- 1696 (20.53/11.77)	IGNIRGADS.GA
 1717- 1728 (14.94/ 6.37)	VGNIRALSAfGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.36|      13|     702|     847|     862|      26
---------------------------------------------------------------------------
  823-  835 (24.27/12.39)	PT...PIEHLLDKNTP
  847-  862 (20.09/17.54)	STtasPYVHPTPSVEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP09000 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AASSNNSQDQTSPNNSPVVAEASGENATTNPSGSTMPKP
2) AAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHH
3) ISDHNSPDRMEDNRSWQSAGGNNFNSAQQQDVE
4) ITRKQRSLAAQHHHAAAASTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPTSVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNTMGGGGPNLNDNMPTSGLGGTNQPASVGRCTPTIQQQQSSSSQQQQHSHQQQQCGTITVKR
5) LNPPDVNVHVASHNNTRLSASGNTSSPMAGTITGLEGSDRGDHTSSTPMEHGDLSQHANADTAGNMNDNKGTDVKPDVKPPL
6) NLPSQTMAPLITPPNCVYKPSWQPTRSTHQQPQQQQQLQQHNQSLQQQQNHQQQQPQHQQHQQLHELLSSAPRTPLQQPRTPLGPMSSSPMHNTVPTPLSSGGGGGGSLLLNQLNCPQAALTNTPPAMQQLMQRAGMSPISPASHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVAS
7) NPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAASNATI
8) VKLESSGLQANPTSSSVTSTSHSTTTLNTILPNNLKRNSSTQSS
235
1586
2646
727
2167
1401
1200
957
273
1622
2678
932
2248
1576
1243
1000










Molecular Recognition Features






MoRF SequenceStartStop




NANANA