<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08997

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSAVNNKLTAIGAGSINPTALLTSMSNAIEKNKQWQRELLMERIRSHSSQHKTFQELSKAMRMGMLEKRYALDAVEKSNLQKCLDSMQHCIKVTSRQGLVERLESLSRQLGLKFMDDTKVLFISTDMFFLEIVLDANGALSDVKVHHECKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAEPKVKTKAFDAMQAVETDLYNLFQMQSFSKDTQQVLKDSIVGIVLKRHGGHPMRLVYFVSPYDLISLESKSLQALSLDLLHNKQIGFSVTVNLEASSANKLQILPTVSFAKESQSGLEVPVFAPLNQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCSSPSTSQVPAADINNSTVLEGQHKATLPMVSNIMSLIIYTASEQQLKNSQKGLFVCLPDQTHCYFFTENKLLKSTLVHSIPFTEPSQVPKILDFLKRQALFYALLSSCIRPQSKIVNDIDSTIILEVNAISYHQISVALQHPYEESMATVEFDLHNGNVQCIIYSLSNNYDLLSLKLTNVVQKCCSIPVTIRALLRYWDQERMKKFQRGIGAAAGSTGANTSNNGSGAVGTNNAYGNFNIAGVTNDPGGGGGGVGGGGGGCMNRGLGGSVKIEQPLQQRTQLANATTGYLKYKCGDIKQEDFHESPKSQTLAMVTETAAANSMPVREVSSLGQQQQQTTHETFQQQANTTFTAEREIVDKYKNIWKDKTPAIKNCLSITPIGTQHDAMKDVKRTGGIEIIPLTGQQHNSIAGTVNNGSSTAVSNSSTGITITPINAGSSSMSISGVSGKDKKSSTTSSTCISNLSSSTTSTKRALDVQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASTVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATAASPKGDKSSTTAAIGSSSSSGLNTVALVRSSTSSTVAAAAAAAAAAMAALKSKDKSAVSPAAVNSAVAAAAAAVVKSSMGVVTPTIQLKNISSLNHMAVAPAGFGGNTTTVSSLDLNAAMRKSVPSAVSLMTSTAVTATVNSTSTQRRAIHQVHRHQQRPVPLQPLGSSESDGNTFNKNSSEYMVKSQSQEGLKLTINKTKAISTKKFSINNDPACKKFSASEKSWSPSQSRHTFQKSNSSGNLAGKLNKSRSLENNIEYLSNDNLRKCIKKSPASASSTTSTHMPSLSASPSQSALRIDYHADMMKILQYASPTMAASMEGFMKSLNTKFQIPKLSQRNTTKTVTATTTAASVAETNKIGSLCAATNTTSICPSSTTRAGDVQTPSLSPSLNASSQQPTITAADTPIIASTNKSLVSLHVLKSSSISSTSPNHINSLTAAKSALNFVDNSNVPNNSMCNESLLATLAGE
Length1413
PositionMiddle
OrganismGlossina brevipalpis
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.306
Instability index50.91
Isoelectric point9.46
Molecular weight150641.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08997
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.60|      24|      24|     896|     919|       1
---------------------------------------------------------------------------
  838-  860 (25.71/ 8.84)	.SPMGPPekIYS..RQNS....PAGSSEAA
  864-  891 (29.75/11.45)	VARKFSS..PSSSPKGSSggllASTVTGSS
  896-  919 (48.15/23.35)	PSPKHSP..VYSSPKHNT....ASNSPKSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     115.60|      23|      24|     934|     956|       2
---------------------------------------------------------------------------
  769-  802 (23.49/ 7.54)	SStgititpinagSSSMSISGVSGK..DKKSSTTSS
  934-  956 (36.94/16.03)	SM...........STLKNATAASPK..GDKSSTTAA
  961-  981 (26.70/ 9.57)	SS...........SGLN..TVALVR..SSTSSTVAA
 1033- 1056 (28.48/10.69)	NI...........SSL.NHMAVAPAgfGGNTTTVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.83|      70|     102|     152|     223|       3
---------------------------------------------------------------------------
  152-  223 (110.79/74.87)	EQQSCSEL.VDCLNRGDFA.DFTAQLEGfSSIYQLNAEPKVkTKAFDAMQAVETDLYN.LFQMQSFSKDTQQVLK
  254-  326 (100.04/59.26)	ESKSLQALsLDLLHNKQIGfSVTVNLEA.SSANKLQILPTV.SFAKESQSGLEVPVFApLNQMNSMLLPATFVLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.39|      20|      22|    1304|    1325|       5
---------------------------------------------------------------------------
 1304- 1325 (33.23/20.36)	GSLCAATNTTSICPSSTtrAGD
 1329- 1348 (33.17/14.73)	PSLSPSLNASSQQPTIT..AAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.20|      71|     314|      50|     129|       6
---------------------------------------------------------------------------
   50-  129 (112.32/93.29)	QHK.TFQELSKAMRMGMlekrYALDAVEKSNLQK....CLDSMQHCIKVTSRQGLVERLESlsrqlGLKFMDDT...KVL.FISTDMFF
  366-  445 (104.88/68.54)	QHKaTLPMVSNIMSLII....YTASEQQLKNSQKglfvCLPDQTHCYFFTENKLLKSTLVH.....SIPFTEPSqvpKILdFLKRQALF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.63|      21|      21|    1360|    1380|       8
---------------------------------------------------------------------------
  989- 1008 (26.76/12.29)	.AMAALKSKDKSAVSPAAVNS
 1360- 1380 (35.62/19.02)	VSLHVLKSSSISSTSPNHINS
 1386- 1400 (25.25/11.15)	SALNFVDNSNV....PN..NS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.02|      20|     264|     234|     253|       9
---------------------------------------------------------------------------
  234-  253 (39.67/28.84)	HGGHPMRLVYFVS.PYDLISL
  499-  519 (33.35/23.00)	HNGNVQCIIYSLSnNYDLLSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08997 with Med1 domain of Kingdom Metazoa
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