<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08992

Description Uncharacterized protein
SequenceMIIAHKVEKMERFAIKIDKKLKANLYKICRLCGMDHPDMVQILTENKNEEEKDPIMVDAEPQLSQKIQELIGLTISKDDRMPQTMCTLCVEKINDFYEFRDMCYATNAQTRKLLGLKHQEVKKQLPVLDIKTELSIKEEMSSSSVLINKANNRKRKSDDVTVKKEASANAAVSNKKLRLASQTLKETALKKVNKQKLSNIDNKTAEFKEEIKEEIKEEPGASVNLITTMPGGTATVVTPSSKLKQICTICPERFASKAKLEAHFRTCHIPRVERYVCTACDEILNKNFDIKNHQLWHRHSKTPYKCGLCDERVLSFYAYAKHLRDHSFETPPALLVLDRECPQCQNSYATNFLYNIHPCAVHTKRCAGCNRLQRSESEYLKHSAQCAKVYLNYSKHILPAVAAMEDSVRIKNENEVEAAAEEYVRYSGAAVNMNPVVSLTRLGSPLLRSSNSAVIPGSNQQEETAKKSSKSRVSKKDFKRVDELLKSTFDTLVSIKHEPEMHMDTDLSVSVTDSGLESNERESNEQEDTDENNHSDGDYADHNDDSNDQEMSSAEIGEAAKIKQEVHDLSYGNSDASNVEYSNKMPVLKLKIKKEHGQLNSSLVDQTTEKRAEKRKKKKKHKEKEKTISDYENVKAVSGEEVQEANLCIKTEPIDMETDVNTVDLNPQPEATIMTSIPMMQLKIARISEGVEFNSSSAKDDQIEETLNRDLMPFEEDIKPNREELDNLLKITLVTGGVEMQSTAPVENSSLQSTLEEDSVSENYEHLDEQQNDILGKEIKQKAPLKWTKGRNKACKSTAGRMCKVSNTETAELQISSIHGGVSMLEHSATPEMMPVFIKAEPQRGYSDELTELTADELDNSVEGNENIAKISSIHGYVGEEIDFANIKIKQEKDLDIHDVQMSSMQTINGLKAKKFFVNNSNQGLENQEEYDECNYGDDDDDEDDIDEEEDEDSDEEDDEIEEEEEEREYREMELPPALDANHAEDETSDVNLKADFQSPTEVIGNPQIPFIISNVCTAPVTTNQQPQQECTDIPKHSENDLPVTDINAMVTETGTNPTPVKYDPDGNRGKIDLTQIMLAPQTSQPRDLTISSIAAGCSVNFSPTLAISNQEADETPPVPNVLEVPTASKKAFQTHYGNRGDDESVNLTLTRVREGIVQEPKDVQLDAQPFGDTVSIGNANLDQNIEEQQNQHNQQILEQHQQRHPRLTALVMHPYLEDISSSTSSILSDSLLETPRCSTAPLHIHQNVEETENILNESNRHLSRNFNFDNINEIAENNNNANIERELQDGEQARQALEQQAQDPQQASEEQQVAEQQQVSEQSQASEQQQTEEQRQTQEQQQIQEQQQTEEQQQAQEQQQSQDQQQQVQVQGPVQEQRTDDDVT
Length1385
PositionKinase
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.04
Grand average of hydropathy-0.874
Instability index57.10
Isoelectric point4.77
Molecular weight156382.44
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:InterPro

GO - Biological Function
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08992
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     163.78|      16|      16|    1328|    1343|       1
---------------------------------------------------------------------------
 1187- 1202 (28.03/13.68)	EEQQNQHNQQILEQHQ
 1287- 1302 (24.10/10.66)	ELQDGEQARQALEQQA
 1304- 1319 (26.94/12.85)	DPQQASEEQQVAEQQQ
 1328- 1343 (32.09/16.80)	EQQQTEEQRQTQEQQQ
 1346- 1361 (32.87/17.40)	EQQQTEEQQQAQEQQQ
 1365- 1379 (19.75/ 7.32)	QQQQVQVQGPVQEQR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.79|      15|      16|     938|     952|       2
---------------------------------------------------------------------------
  938-  952 (27.54/13.96)	DDDDDEDDIDEEEDE
  955-  969 (26.24/12.93)	DEEDDEIEEEEEERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     132.10|      26|      28|     277|     303|       3
---------------------------------------------------------------------------
  247-  267 (30.28/15.26)	............CTICPERFASKAKLEAH...FRTC
  268-  300 (38.12/25.66)	HIP...rveryvCTACDEILNKNFDIKNHqLWHRHS
  301-  327 (39.62/22.18)	KTP.......ykCGLCDERVLSFYAYAKH..LRDHS
  329-  357 (24.08/10.68)	ETPpallvldreCPQCQNSYATNF......LYNIH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     209.74|      34|      56|     974|    1007|       5
---------------------------------------------------------------------------
  974- 1007 (57.77/39.45)	ELPPALDANHAEDE..T.SDV..N..LKADFQSPTEVIGNP
 1033- 1065 (31.37/17.41)	DIP.....KHSENDlpV.TDI..NamVTETGTNPTPVKYDP
 1078- 1111 (35.20/20.61)	MLAP..QTSQPRDL..TiSSIaaG..CSVNF.SPTLAISNQ
 1115- 1143 (41.54/25.90)	ETPPV..PNVLEVP..T.AS.......KKAFQTHYGNRGDD
 1147- 1180 (43.87/27.84)	NLTLTRVREGIVQE..P.KDV..Q..LDAQPFGDTVSIGNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     143.57|      27|      29|     502|     528|       6
---------------------------------------------------------------------------
  433-  463 (24.72/11.00)	.MNPVVSLTRLGSPLlrSSNSaviPG..SNQ........QEE
  480-  500 (22.12/ 8.98)	RVD.ELLKSTFDT.L..VSIK...HE..PE............
  502-  528 (46.21/27.66)	HMDTDLSVSVTDSGL..ESNE...RE..SNE........QED
  534-  566 (26.36/12.27)	HSDGDY..A..DHND..DSND...QEmsSAEigeaakikQEV
  567-  584 (24.16/10.57)	H...DLSYGNSDA.....SNV...EY..SNK...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      24.67|      11|      15|    1244|    1258|       7
---------------------------------------------------------------------------
 1257- 1272 ( 9.68/ 9.83)	NEsnrhLSRNfNFDNI
 1273- 1284 (14.99/ 6.37)	NE....IAENnNNANI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.58|      47|     155|      19|      74|       8
---------------------------------------------------------------------------
   19-   66 (77.59/57.61)	KKLKANLYKIC..........R.LCGMDHPDMVQILTENKNEEEKD.PIMvDAEPQLSQK
   79-  137 (62.99/30.08)	DRMPQTMCTLCvekindfyefRdMCYATNAQTRKLLGLKHQEVKKQlPVL.DIKTELSIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     241.24|      49|      54|     696|     744|      11
---------------------------------------------------------------------------
  650-  694 (36.02/21.59)	...KTEPIDmETdVNT.............................vDLNPQPEATIMTSI.PMMQ.LKIAR..ISEGVEFN...
  696-  744 (78.15/57.88)	SSAKDDQIE.ET.LNR..............................DLMPFEEDIKPNRE.ELDNLLKITL..VTGGVEMQSTA
  753-  783 (41.93/26.68)	STLEEDSVS.E..............................................NYE.HLDEQQNDIL.....GKEIKQKA
  788-  866 (43.14/27.72)	TKGRNKACK.ST.AGRmckvsntetaelqissihggvsmlehsatpEMMPVFIKAEPQRG.YSDELTELTAdeLDNSVE..GNE
  867-  904 (41.99/26.73)	NIAKISSIH.GY.VGE..............................EI.DF.ANIKIKQEkDLD..........IHDVQMSS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.82|      15|      25|     152|     166|      12
---------------------------------------------------------------------------
  152-  166 (23.85/15.68)	NRKRKSDDVTVKKEA
  174-  188 (22.97/14.82)	NKKLRLASQTLKETA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.14|      19|      27|    1206|    1228|      13
---------------------------------------------------------------------------
 1206- 1228 (28.54/25.19)	PRLTA..LVMHPYLEDisssTSSIL
 1236- 1256 (30.61/17.18)	PRCSTapLHIHQNVEE....TENIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08992 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EMQSTAPVENSSLQSTLEEDSVSENYEHLDEQQNDIL
2) IVQEPKDVQLDAQPFGDTVSIGNANLDQNIEEQQNQHNQQILEQHQQRHPRLTALVMHPY
3) NNSNQGLENQEEYDECNYGDDDDDEDDIDEEEDEDSDEEDDEIEEEEEEREYREMELPPALDANHAEDETSDVNLKADFQSPTEVIGN
4) SNVCTAPVTTNQQPQQECTDIPKHSENDLPVTDINAMVTETGTNPTPVKYDPDGNRGKIDLTQIMLAPQTSQP
5) STSSILSDSLLETPRCSTAPLHIHQNVEETENILNESNRHLSRNFNFDNINEIAENNNNANIERELQDGEQARQALEQQAQDPQQASEEQQVAEQQQVSEQSQASEQQQTEEQRQTQEQQQIQEQQQTEEQQQAQEQQQSQDQQQQVQVQGPVQEQRTDDDVT
6) TLAISNQEADETPPVPNVLEVPTASKKAFQTHYGNRGDDESVNLTLTRVR
7) TLVSIKHEPEMHMDTDLSVSVTDSGLESNERESNEQEDTDENNHSDGDYADHNDDSNDQEMSSAEIGEAAKIKQEVHDLSYGNSDASNVEYSNKMPVLKLKIKKEHGQLNSSLVDQTTEKRAEKRKKKKKHKEKEKTISDYENVKA
739
1157
919
1014
1223
1105
491
775
1216
1006
1086
1385
1154
636










Molecular Recognition Features






MoRF SequenceStartStop




1) QDQQQQVQVQ
2) QIQEQQQTEEQQQAQEQ
1363
1343
1372
1359