<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08980

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSVNNKVTTIGTGSINPTTLLTNMSNAIEKNKQWQRELLMERIRSHSSQHKTFQELSKAMRMGMLEKRYALDAVEKSNLQKCLDSMQHCIKVTSRQGLVERLESLSRQLGLKFMDDTKVLFISTDMFFLEIVLDANGALSDVKVHHECKVEQQSCSELVDCLNRGDFADFTAQLEGFSSIYQLNAEPKVKTKAFDAMQAVESDLYNLFQMQSFSKDTQQVLKDSIVGIVLKRHGGHPMRLVYFVSPYDLISLESKSLQSLSLDLLHNKQVGFSVTVNLEASSANKLQILPTVSFAKESQSGLEVPVFAPLNQMNSMLLPATFVLRLNKPLPVCYNTLRAMGLCGSPTTSQSSAADINNSTVLEGQHKATLPMISNIMSLIIYTASEQQLKSSQKGLFVCLPDQTHCYFFTENKLLKSTLVQSIPFTEPSQVPKILDFLKRQALFYALLSSCVRPQSKMVNVDIDSTIILEVNAISYHQISVALQHPYEESMATVEFDLHNGNVQCIIYSLSNNYDLLSLKLTNVVQKCCSIPVTIRALLRYWDQERIKKFQRGIGAAAGSTGANTSSNGSNAVGNNSAYGNFNIAGVSNDPGGGGGGGGGGCMNRGLGGSVKMEQALQQRSQLASTTPGYLKYKCGGDIKQEDFHESPKSQTLAMVTDTTVANSMPVREVSSLGQQQQQTTHETLQQQANATFTAEREIADKYKNIWKDKTPAIKNCVSITPIGTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSMNISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDAQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKSSTAAAMGSSSSSGLNSAALVRSSTSSTVVAAAAAAAAMAALKNKDKSTVSPSAVSSAAAAAAAAVVKSSMGVVTPTMQQLKNVTGLNHMAAAAAGFGGNTATVNSLDLNAAMRKGVPSAVSLMTSTAVTATTNSTPAQRRATQPVHRHHQQRPIPLQPLGSSEGDNHTFNKNSSEYMVKSQSQEGLKLTINKTKAISTKKFGVNNDPTCKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLNKNKSLENSIEFLSNDNLRKSVKKSTVSTSSATSTHMSSLSAAPSQSALRIDYHADMIKILQYASPTMAASMEGFMKSFNTKFQIPKLSQRNATKTTTATTAASIADTSKSGSLCITTSITKTCPSSTTSVSDVQTPSLPPTSNASSQQQSTMATTETPTIVNANQSLVSLHVLKSSPISSTSPNHLNSLTATKSALNFVDNSNVSNNSMCNESLLATLAGE
Length1413
PositionMiddle
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.347
Instability index50.63
Isoelectric point9.42
Molecular weight150765.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08980
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.83|      30|      31|     901|     930|       1
---------------------------------------------------------------------------
  852-  880 (36.90/15.27)	PAGSSEAAAGAvARKF...SSP..SSSPKGSSGG
  901-  930 (52.96/25.45)	PVYSSPKHNTA.SNSP...KSPFGTHSPKHSSSG
  932-  963 (33.98/13.42)	PSMSTLKNATV.A.SPkgdKSSTAAAMGSSSSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.77|      23|      24|    1285|    1308|       2
---------------------------------------------------------------------------
 1285- 1308 (34.12/20.58)	TKTTTATTaASIAD........TSKSGSLCIT
 1312- 1342 (29.66/13.21)	TKTCPSST.TSVSDvqtpslppTSNASSQQQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.54|      14|      57|    1111|    1124|       3
---------------------------------------------------------------------------
 1111- 1124 (27.15/17.36)	SSEGDNHTFNKNSS
 1132- 1145 (20.39/10.93)	SQEGLKLTINKTKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.46|      36|     105|     172|     223|       4
---------------------------------------------------------------------------
   70-  109 (50.36/20.19)	YALDAVEKSNlQKCLDSMQhciKVTSRQGLVERLESLSRQ
  182-  217 (62.10/36.48)	YQLNAEPKVK.TKAFDAMQ...AVESDLYNLFQMQSFSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.29|      20|     105|     408|     427|       5
---------------------------------------------------------------------------
  408-  427 (36.93/22.66)	YFFTEN.KLLKSTL...VQ...SIPFT
  509-  535 (20.36/ 9.17)	YSLSNNyDLLSLKLtnvVQkccSIPVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     108.71|      23|      23|     967|     989|       7
---------------------------------------------------------------------------
  769-  793 (27.51/ 9.76)	STGITITPINTGSSSMniS...GVS.SKD
  973-  993 (24.57/ 7.95)	STSSTVVAAAAAAAAM..A......aLKN
  994- 1018 (27.04/ 9.47)	KDKSTVSPSAVSSAAA..A.aaAAV.VKS
 1213- 1238 (29.59/11.03)	VKKSTVSTSSATSTHM..SslsAAP.SQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.15|      28|     463|     584|     614|       8
---------------------------------------------------------------------------
  584-  613 (46.55/38.64)	NIAgvSNDPGGGGGGGGGGCMNRGLGGSVK
  623-  650 (47.60/26.90)	QLA..STTPGYLKYKCGGDIKQEDFHESPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.87|      23|     463|     555|     579|       9
---------------------------------------------------------------------------
  555-  579 (33.93/23.21)	IGAAAGSTGANTSSngSNAVGNNSA
 1039- 1061 (38.94/20.37)	MAAAAAGFGGNTAT..VNSLDLNAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      11|      19|     721|     731|      10
---------------------------------------------------------------------------
  721-  731 (22.38/10.22)	ITPI.GTQHDPI
  742-  753 (17.03/ 6.34)	IIPLtGQQHNSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.06|      14|      16|     807|     822|      13
---------------------------------------------------------------------------
  807-  820 (21.30/ 7.75)	LPSSTTSAKRALDA
  824-  837 (21.76/12.58)	LPKEKKRKKKRDDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08980 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTQHDPIQDVKRTGSIEIIPLTGQQHNSIAGTVNNGNSTTVSNSSTGITITPINTGSSSMNISGVSSKDKKSSTTSSTCISNLPSSTTSAKRALDAQGELPKEKKRKKKRDDSPMGPPEKIYSRQNSPAGSSEAAAGAVARKFSSPSSSPKGSSGGLLASCVTGSSLTTRPSPKHSPVYSSPKHNTASNSPKSPFGTHSPKHSSSGKPSMSTLKNATVASPKGDKSSTAAAMGS
2) KKFGVNNDPTCKKLSASEKSWSPSQSKHTFQKSNSSGNLAGKLN
3) LMTSTAVTATTNSTPAQRRATQPVHRHHQQRPIPLQPLGSSEGDNHTFNKNSSEYMV
4) QEDFHESPKSQTLAMVTDTTVANSMPVREVSSLGQQQQQTTHETLQQQANATFTA
5) SSTTSVSDVQTPSLPPTSNASSQQQSTMATTETPTI
725
1149
1072
642
1317
958
1192
1128
696
1352










Molecular Recognition Features






MoRF SequenceStartStop




NANANA