<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08978

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTILYKVQSVCGCKEAVASVLEWNPTGELLLVGYKHGLAEIWGMKANCMNSWFLLYTVNLPCEEIINVKFFHNSKATYFNMQKKDLQNYSDKYERLDQRPTLAYFGCSPVEGCFLLTASGLMGVFTIPRIPMNPETSNSASPSELNIFTNSIGLSRCFITHCSISYCPTGRFNVAINNWSEPRISCFKIGVEREQDDTLNLKCGAMASIFLQRADNENKEISVVHWRTVNCEEVAFVVYDCMEGSFIEQWNLIKKHQQVHKLLQKNKSDFMQWEQWEITAKLSLTSRVCDLSLSKLPTESLLLFAILRDNSVQILETGLKKIGSTVFERVPEDQMRAPCKLLTSDCTHLNQLLILFDNLGQMYAMQVPTSHYDKNYKMSPLAVPVCLLEYSVITGIDAADVLMLNLSHLEALTEKLTENFSRQTAYVRHFYYSNFLSLKSNICRIQTKQQDFDDLITLHAIAIAFKSLLRPSDLSSQDKGPAENLSMILSEPVGDVDKVLCVLDAKDFTVEPATLQSLQQLIQWVSDLALNILHKLTEDVLKPKFNKRHGYEICRDVIAVSSVRELLVMIRIWGLLNPHCLPIYTKSVDNFDVLPVMFRLLTRLMQNTSEPDDSLLDECSVLSTQVLVPTRHINTPTTLLNSNATSKLFPFVFQTSVESLNLQDVHYEEVLFSHTIKDDIIVGNRVYQHVLRKEERQQATVLEKVEIVSCVSPSSWENSPTIATMFPQLYKIPCNSLSPISTPSLANSHTENLPNYVLNGEAQHLGEMSPKRSNVTVQVKVLADEIAQTKTDDVQAQYNANGENMKSSG
Length809
PositionTail
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.08
Grand average of hydropathy-0.114
Instability index42.36
Isoelectric point5.73
Molecular weight91562.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08978
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.79|      30|     117|     611|     644|       1
---------------------------------------------------------------------------
  611-  644 (46.59/35.77)	PDDSLldecSVLSTQVLVPTRHINTPTTLLNSNA
  733-  762 (55.20/32.01)	PCNSL....SPISTPSLANSHTENLPNYVLNGEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.98|      37|     438|     224|     265|       3
---------------------------------------------------------------------------
  224-  265 (63.07/56.29)	VHWrtvncEEVAF...VVYDCMEGSFIEQWNLIKKHQQVHKLLQK
  665-  704 (57.91/39.24)	VHY.....EEVLFshtIKDDIIVGNRVYQHVLRKEERQQATVLEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.56|      22|      26|     137|     158|       7
---------------------------------------------------------------------------
  108-  125 (23.68/10.57)	....SPV.EGCFLLTASGLMG..VF
  137-  158 (38.62/21.43)	SNSASPS.ELNIFTNSIGLSR..CF
  163-  187 (32.26/16.81)	SISYCPTgRFNVAINNWSEPRisCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.82|      26|     529|      41|      70|       9
---------------------------------------------------------------------------
   41-   70 (44.41/35.35)	IWG.MKANCMNswflLYTVNLPCEEIINVKF
  572-  598 (46.41/26.23)	IWGlLNPHCLP....IYTKSVDNFDVLPVMF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08978 with Med16 domain of Kingdom Metazoa
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