<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08975

Description Uncharacterized protein
SequenceMAPAPQPLEQALAGYLPQGQEGSSRMNTISLSVLIDFTIQRTYHDLTVLAELLPRKSDMERKIEIYNFSARTRQLFIRLIALVKYANSVSKVDKSANIMSFLDKQNMLFIETADMLARMSRETLVRARLPNFHIPAAVEVLTTGTYNRLPTCIRERIVPPDPITPQEKKQTLLRLNQVIQHRLVTGKLMPQMREFKIRNGRVIFEVKHEFNVSLTVMGDNANVPWRLLDIDILVEDKETGDGKALVHPLQVNYIHQLIQVRLVENPNALCEVYNCLHYFCQSLQLEVLYTQTLRLSYERLDDNINVEEYIPGYKITVSYWRELTSKDPKSELGYRLTVQSDPNEIGRPLAVVHVPSLGAKESAEVADRAVRSDHLSMERLIVHTVYIRSVSRLSDLKLEFQAFLKDVDFNLQGTPAILTVPVLTPCLRAEQIHITIDTHTGMLRCHVPKHLDCPIMPEMQACLNGDRSKLPQIMTELRYWITHRRCEKTLQHLPATATENLTFLNMPDHPLLQSGRHKIYVKLHRHPNVVLVVHLKEKSSMPNEMEYTFYLGLLVYQSNETEALSEDLTKQLVPVQTSNSNVENQGSHHHEIPKVFAKLLRLIEFDTFVATHGPGTDVDDVPPHKRKSNSELTAPPTKQAKTIYPAYIIPDLAHVVAMCDEKIPFLNLAQALTKYNVPHCGLQVESNAISLVLKIITLPQPTPPDDRKSQFPVIESNVWDDLMKRVLSISIRSHMNKSNKIRSWVMEFIFYSTPLQSIHPREQGNRRTLYLSYDQISNYSQTVEDLLKDWSKIVYLYTLVYSFAEHIKNKRLNITDMLSINSYNYTNLLLGYGPKKEVLCNIFWSAPVGGFHMTFLGGITAVNAHSVIRDQLAIYLNTKHNLTQIVQLLHETYNPLSSIAKLPIIPHLGIPRPQVPVLSFCILPQSPCVIRLAYQAVYCLEIRFRSGRLISIRDGAYSRFDRNLIEEFTPIQGLKGFLSKYVDENAVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSAINQNTNSGSGSSSQVINRMPPPNRSYAGAVPTLLTHEKFDLLCRPSPHPNKDITSTIDISPLERFLGCVYMRRQLYRNVQNEDTLTALNSNEPGVVLFKVDGLQCQVILNQVHMQSLHLKVNQLPPPHTPDSKQPFQLSPDDLLIIEKFFDTRVAAPPYRPNALHGFSRVLSCAPQVLKDFLQIMRLEMNPDLGGDQIKWTVQFCMRVPPSAAPIVPIGSPGVLMVRLKILFFLQITRIPYNGKEWKDSPSLVLPMVYDLSSNLTQLAEKREQPQSPAATAVSAVLRHFSDHLAQPGQCSLFPAVREILISLQLPNDVPPQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
Length1541
PositionTail
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.07
Grand average of hydropathy-0.300
Instability index53.83
Isoelectric point8.64
Molecular weight172290.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08975
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     229.10|      31|      32|    1089|    1119|       1
---------------------------------------------------------------------------
 1000- 1024 (33.98/11.19)	P..........SP..........................I.....G.G...EDN.FGGPGSASGASAGGSS
 1025- 1051 (38.40/13.72)	PflS..TGM..............................R.....G.P...QSP.RDS.GLRFP.APHTPP
 1052- 1110 (46.33/18.27)	S..SsnPHTPASPhpsagggvgtgssnaqshpnynltspP.....G.P...HMP.HPSPGALMPSSPLNPQ
 1111- 1130 (26.29/ 6.78)	P..S..PHMVHSP................................G.PntlYMQgH..............Q
 1131- 1158 (32.94/10.59)	D..S..PFAAMSP.....................antnwP.....GsP...SMP.RPSP.........RPG
 1507- 1539 (51.16/21.03)	P..N..P.MMHSP...........................mqqmgG.P...VGP..PQIGPGYPQMPQNPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.33|      21|      24|     145|     168|       2
---------------------------------------------------------------------------
  145-  166 (35.79/27.09)	TYNRLPTCIRERIVpPDPITPQ
  171-  191 (36.53/16.25)	TLLRLNQVIQHRLV.TGKLMPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.21|      16|      19|     442|     460|       3
---------------------------------------------------------------------------
  445-  460 (33.73/22.46)	CHVPKHLDCP.IMPEMQ
  462-  478 (24.48/ 7.23)	CLNGDRSKLPqIMTELR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     257.91|      90|     593|     622|     723|       4
---------------------------------------------------------------------------
  622-  694 (89.02/58.25)	...............................P.PH..KRKS.NSELTAPPTKQ......AKTIYPA.YIIPDLAHVVAMcdEKIPflNLAQALTKYNVPHCgLQVESNAI.............................................SLVLK
 1186- 1290 (42.58/29.21)	INRMPPP..NRSYAGaVPTllTHekFDLLcrPsPH..PNKDiTSTIDISPLE........RFLGCV.Y..........................................mrrqlyrnvqnedtltalnsnepgvvlfkvdglqcqvilnqvhmqSLHLK
 1291- 1386 (126.30/72.06)	VNQLPPPhtPDSKQP.FQL..SP..DDLL......iiEKFF.DTRVAAPPYRPnalhgfSRVLSCApQVLKDFLQIMRL..EMNP..DLGGDQIKWTVQFC.MRVPPSAA.............................................PIV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.50|      30|     370|      24|      54|       5
---------------------------------------------------------------------------
   24-   54 (48.30/37.54)	SRMNTISL...SVL..IDFTIQRTYHDLTVlAELLP
  391-  425 (42.20/27.45)	SRLSDLKLefqAFLkdVDFNLQGTPAILTV.PVLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.15|      22|      23|    1431|    1452|       9
---------------------------------------------------------------------------
 1426- 1447 (36.74/21.33)	MVYDLSSNLTQLAEKREQPQS....P
 1448- 1473 (30.41/16.39)	AATAVSAVLRHFSDHLAQPGQcslfP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.96|      19|      22|     241|     259|      16
---------------------------------------------------------------------------
  241-  259 (32.32/20.75)	DGKALVHPLQ.VNYIHQLIQ
  265-  284 (29.64/18.34)	NPNALCEVYNcLHYFCQSLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08975 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVYRGRSQNEDDNPPSPIGGEDNFGGPGSASGASAGGSSPFLSTGMRGPQSPRDSGLRFPAPHTPPSSSNPHTPASPHPSAGGGVGTGSSNAQSHPNYNLTSPPGPHMPHPSPGALMPSSPLNPQPSPHMVHSPGPNTLYMQGHQDSPFAAMSPANTNWPGSPSMPRPSPRPGQSPDHKSGQSSAINQNTNSGSGSSSQVINRMPPPNRSYAGAVP
2) PQSQAIGPPIGARVGSSPNPMMHSPMQQMGGPVGPPQIGPGYPQMPQNPGPQ
986
1490
1201
1541










Molecular Recognition Features






MoRF SequenceStartStop




NANANA