<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP08967

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMERFVLTKDIVRFGKWFVQPCTSNERIFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLSEAAAAFTTVAASSNNSQDQTSPNNSPIVAEAAGENSAANANGSNMPKPRKVILAPFGMAATLTGNSYKANDPLAEKILEDWASFFPLCNKENSDVPPVVEVISGGHKMYHPSIYVLVTDLDDMEEMEAAASQKGSLGTSSSAEAAALTTLSSVNTGDNLSSNVRKPLTETVSNKLTTNTNQTASSKSLAYMVERLKIDPKKVQNHYDALTSNYTCNTTNTHAPPQAATEMPERAWQDCVTNSLHAQYANTAIPANFNENISVIGNGGSNGGSGGGASIGDCGGEQQADIKPNTLALLQKQQIWDFVDPTQKAPCICTNTKSLTKVTATATATAAAAATAAATVAAAATTTTITSLSSSSSLSSSSSSSSSSCSALSLAAQHHHAAAATTPGHGTPLQGANGGASSYSRNSVMDTMPVPSVGSPGTPAPSPHPNSTLSQPTSVPPADQLLAMSPRAPASVSNLQQPPTPIEHLLDKNTPAPTPTDQNDNKSTTASPYVHPTPSVEPPPSVEGIHNIIGGAGGGGGGGGGGGGGGGGGGGVVGVAVGGPNLNENIQSSGIGGGGGGGTNQPASVGRCTPTIQQQQSSSQQHQQQQQPQQQQQQQQQHQHQHQQQQPQQQHSHQQQQCGTITVKRFDLQPTLPATVIGFSANVVASAGEVKLESSGLQLNPTVSSASSTSHSHSHSTTTLNAMLPNSLKRNSSTQGSAGNSIHAMHDFLNLYKPPKICVKDIDSFANDDCLKLDVLYDFTVQDAWSYHTIKRFKPNDLSKPCRIMRTKNLYEGHTHIKPLMPSPRSLLAADSVQAAQMASASGADSSTVMADMSGGLVGIASNNQNISRLANDNSAGPMTAVGSSTTSNFFEELDIKTEMMSGTASGTSSISPCKDSKSGIGGNLFTVEGLNPSPNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGCAISNTAIDDLKRSTNPAILANSNVAIANSTAGAAVMVALQNCNNSSASSTSAVSSLNNSVGNISGGANIIQAEDLTKMFPTPPSHEQHHPNSSPCQMDIHMTDLSVITNLGPNLDTGLGMLKIKQEYSIELGSPIEEPIEDWSYVYRPPQQAKFVGSSNGGGGGGSLLLNQLNCPQAALTNTPSAMQQLMQRAGMSPVSPAPHVPFPHTSPMMHHQQRQTPIHPPPPYEVAVASPALSSASSTAAYINKQYHSQEPPHTPQSVANLHSVGGPPSVSGVHHPSASLGLFSGTVSNTSANAVTRELPEVSSLIVNILLYDTALNVFRDHNFDSSTVCVCNADSQRIGNIRGADSGVYVPLPGTSFNPSPLTSSATTVGNIRALSAFGAVSSGGGGGGGIGSALDSPASLAGAGSSSSTTPSTTTPASNGQQHITGYVDDDSVECTCGFSSVINRRLAYGAGLFYEDELEITGIAEDPGRNKKQSLLTLISSFTSKSNGTNGNGVMDKAADQLAYSIFNLLLDQCSIIQTSSSAVHRALQRHRRRLAKRNRQPQSVTTIANVLEYMDANDIISLALEQARLAFDSSRVDVMDQQIIAFSHRKSGSQTILALTGRLNVHKWPYMPVGFSRSNKDIVSTMKSIQPMLQNAFHSKSRSAAGAKDATYTVSGPLTWRQFHRLAGRASGQCEPQPIPSVIVGHDKDWISVAPLAIHYWDKFLLEPYSYARDVVYLVIAPDNDYVISKTKTYFKELSTTYEMCKLGKHTLMCGWGGMLTVSQRPPTEKPYTTNMDNWLRTMDDTTLAEKLRLYAHAFQHMLVPYLNRIPNDKSLLNPPDANIHAGSHNNTRLNASGNTSSPMAGTITGLENSDRADHASSTPMEHGDLSQHATTDTSGNINDNKGTDVKPDVKPPLVLGDPLGVGETLEEINPPAIVLYVVEPFTYGSDSPELERLACIAILRMYSELLKSIPESVRANMNIQIISLESILELGRTRNRKRFSDEIKCLALNIFSQCRRHMVHAQAVKSLTGFGTAANIEAFLKSKDDQNRRPYKMYTPPYILAPIHEKNEKTDFSRAASGGMRGSPNEQKYSVMYCNYCMSEDQSWLLATVTDDRGEMLEKVCINIDVPNRTRRRKAPARRIGLSKLMDYILGLISQTTQTWRLVLGRIGRIGHSELKSWSALLSKQNLQKATKQLKDMCKQCQLMYPPSILSACLVTLEPDAKLRVMPDQFTPDERFSQISIQNPLSTPQDVTCTHILVFPTSAVCLSFTRQFQNEPQVDLDNDFLNFEEDENEAFADTDLDDLLIWENRGISDHNSPDRMEDNRSWQSAGGNNFSSAQQQDVEEVGSINQQPLAVGYLVSTAPTGRMPSWFWAACPHLEDVCPVFLKTALHLHVPNIQTTDDILNSTNAHSSATDHPLDSTLTADVLRYVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLYYLTAAIA
Length2469
PositionMiddle
OrganismGlossina austeni (Savannah tsetse fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Hippoboscoidea> Glossinidae> Glossina.
Aromaticity0.05
Grand average of hydropathy-0.372
Instability index51.02
Isoelectric point5.98
Molecular weight264152.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP08967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.08|      22|      22|     649|     670|       1
---------------------------------------------------------------------------
  649-  670 (43.04/22.30)	QQQQSSSQQHQQQQQPQQQQQQ
  672-  693 (46.04/24.34)	QQHQHQHQQQQPQQQHSHQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     144.68|      20|      29|     586|     614|       2
---------------------------------------------------------------------------
  330-  350 (35.57/ 8.02)	SVIGnGGSNGGS..GGGASIGDC
  586-  605 (41.62/11.16)	GGAG.GGGGGGG..GGGGGGGGG
  625-  642 (34.30/16.32)	SGIG.GGGGGGT..NQPASVG..
 1393- 1414 (33.18/ 6.78)	SGGG.GGGGIGSalDSPASLAGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.24|      19|      21|     498|     518|       3
---------------------------------------------------------------------------
  474-  495 (28.06/ 6.99)	SYSRNSvmdTMPVPSVGSPGTP
  498-  516 (37.18/12.80)	SPHPNS...TLSQPTSVPPADQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1081.09|     286|     538|     700|     990|       4
---------------------------------------------------------------------------
  700-  990 (477.40/272.60)	KR.FDLQPTLPATVIGFSANVVA....SAGEVKLESS...............GLQlNPTVS.....SASSTSHSHSHSTTTLNAM...LP..NSLKRNSSTQGSAG.NSIHAMHDFLNLYK.PPKICVKDIDSFANDDCLKLDV.LYDFTVQDAWSYHTI..KRFKPNDLSKPCRIMRTKNLYE...GHTHIKPLmpSPRSLLAADSVQAAQMASA..SGA..........................DSSTVMADMS...GGLVGIASN.NQNISRLANDNSAGPMTAVGSSTTSN.........FFE.ELDIKTEMMSGTA.........SGTSSISPCKDSKSGIGGNL...FTVEGLNPSPNDleQLFETSSN...DECSSVQ
  992- 1260 (329.80/176.00)	HTpPDSNN..PSNGCAISNTAIDdlkrSTNPAILANSnvaianstagaavmvALQ.NCNNS.....SASSTSA................V..SSLN.NSVGNISGGaNIIQA.EDLTKMFPtPPS...HEQHHPNSSPC.QMDIhMTDLSV........I..TNLGPN.LDTGLGMLKIKQEYSielGSPIEEPI..EDWSYVYRPPQQAKFVGSSngGGG..........................GGSLLLNQLNcpqAALTNTPSA.MQQLMQRAGMSPVSPAPHVPFPHTSP.........MMH.HQQRQTPIHPPPP.........YEVAVASPALSSASSTAAYInkqYHSQ..EP........................
 1261- 1530 (273.89/145.03)	.......PHTPQSV....AN.............LHSV...............GGP..PSVSgvhhpSASLGLFSGTVSNTSANAVtreLPevSSLIVNILLYDTAL.N.VFRDHNF....D.SSTVCV......CNADSQRIG....NIRGADSGVYVPLpgTSFNPSPLTS...............................SATTVGNIRALSA..FGAvssgggggggigsaldspaslagagsSSSTTPSTTT...P.....ASNgQQHITGYVDDDSV..ECTCGFSSVINrrlaygaglFYEdELEI.....TGIAedpgrnkkqSLLTLISSFTSKSNGTNGN........GVMDKAAD..QLAYSIFNlllDQCSIIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.38|      30|      38|     390|     419|       6
---------------------------------------------------------------------------
  390-  419 (44.34/25.48)	SLTKVTATATATAAAAATAAATVAAAATTT
  429-  458 (49.03/29.06)	SLSSSSSSSSSSCSALSLAAQHHHAAAATT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.15|      52|    1338|     518|     576|       8
---------------------------------------------------------------------------
  518-  576 (87.80/74.75)	LAMSPRAPASVSnlqqppTPIEH.LLDKNTPAPTPTDQNDNKSTTASPYVHPtPSVEPPP
 1864- 1916 (91.34/58.70)	LENSDRADHASS......TPMEHgDLSQHATTDTSGNINDNKGTDVKPDVKP.PLVLGDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.74|      73|    1548|      82|     156|       9
---------------------------------------------------------------------------
   82-  156 (121.04/69.53)	SNNSQDQTSPNNS..PIVAEA..AGENSAANANGSNMPKPRKVILAPFG.MAATLTGNSykANDPLAEKIL...EDWASFFPL
 1629- 1709 (108.71/56.87)	SRSNKDIVSTMKSiqPMLQNAfhSKSRSAAGAKDATYTVSGPLTWRQFHrLAGRASGQC..EPQPIPSVIVghdKDWISVAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.67|      11|    2024|     177|     187|      11
---------------------------------------------------------------------------
  177-  187 (23.41/15.97)	MYHPSIY..VLVT
 2202- 2214 (19.26/11.49)	MYPPSILsaCLVT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP08967 with Med13 domain of Kingdom Metazoa
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